trans-Fatty acids in the diet stimulate atherosclerosis

Bassett, Chantal M. C.; McCullough, Richelle S.; Edel, Andrea L.; Maddaford, Thane G.; Dibrov, Elena; Blackwood, David P.; Austria, J. Alejandro; Pierce, Grant N.

doi:10.1016/j.metabol.2009.06.010

Cited by 42 publications

(29 citation statements)

References 28 publications

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“…The iTFAs initiated atherosclerotic development in a dose-dependent manner (T Ͼ R and HT Ͼ HR). These data confirm our laboratory's previous findings (5,6). Including whole ground flaxseed or ALA in the diets containing moderate and high doses of iTFAs (TϩF, TϩALA, HTϩF, and HTϩALA) completely prevented atherosclerotic development (Fig.…”

Section: Resultssupporting

confidence: 91%

“…A diet supplemented with 2% cholesterol was chosen based on previous reports that it can reliably induce atherosclerosis in LDLr knockout mice (15,20). As previously demonstrated, adding iTFAs in the atherogenic diet did not stimulate atherosclerosis beyond the cholesterol-mediated atherogenic action (6). Adding whole ground flaxseed to a diet containing both cholesterol and iTFAs (CϩTϩF) partially but significantly inhibited atherosclerotic development.…”

Section: Resultsmentioning

confidence: 99%

“…Components were identified by comparison with authentic standards (Nu-Chek Prep, Elysian, MN). The aorta was excised, cleaned, and evaluated for the extent of atherosclerotic development, as previously described (6). Atherosclerotic lesion formation was assessed as a percentage (aortic area with developed lesions vs. total luminal surface area ϫ 100).…”

Section: Animals and Dietary Interventionsmentioning

confidence: 99%

“…Elaidic acid (18:1t9), one of the main TFA isomers formed during the commercial hydrogenation of vegetable oils, is known to accumulate in atherosclerotic lesions and adipose tissue and is associated with increased risk of coronary heart disease (14,41). Our laboratory has recently shown that TFA from a hydrogenated vegetable shortening source dose-dependently initiates the atherogenic process, an event not normally observed in the LDL receptor-deficient (LDLr Ϫ/Ϫ ) mouse, unless it is fed a strongly atherogenic diet (6). As a result of the multiple adverse effects reported due to elevated TFA intake, numerous agencies and governing bodies in North America and Europe recommend limiting TFAs in the diet and have mandated regulations regarding TFA levels in the food supply (3, 18,23,29).…”

mentioning

confidence: 99%

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The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Bassett

McCullough

Edel

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Animals and Dietary Interventionsmentioning

confidence: 99%

mentioning

confidence: 99%

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The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Bassett

McCullough

Edel

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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“…However, high content of trans-9 elaidic acid (ELA) has been observed in atheroma plaques and adipose tissue of obese subjects (Bortolotto et al 2005;Stachowska et al 2004). A recent report demonstrated that trans fatty acid from hydrogenated vegetable oil-enriched diet (mainly trans-9 elaidic acid) enhanced the development of atheroma lesions in LDLr -/-mice (Bassett et al 2009). In contrast, trans-11 vaccenic acid (VA) would be able to protect against atherosclerosis development (Bassett et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells

et al. 2011

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Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration of vascular cells. Accumulation of lipids in vascular smooth muscle cells is a feature of atherosclerosis and a consequence of lipid metabolism alteration. Stearoyl-CoA desaturase 1 (scd1) catalyses the production of monounsaturated fatty acids (e.g. oleic acid) and its expression is associated with lipogenesis induction and with atherosclerosis development. We were interested in analysing the regulation of delta-9 desaturation rate and scd1 expression in human aortic smooth muscle cells (HASMC) exposed to cis and trans C18:1 fatty acid isomers (cis-9 oleic acid, trans-11 vaccenic acid or trans-9 elaidic acid) for 48 h at 100 lM. Treatment of HASMC with these C18:1 fatty acid isomers led to differential effects on delta-9 desaturation; oleic acid repressed the desaturation rate more potently than trans-11 vaccenic acid, whereas trans-9 elaidic acid increased the delta-9 desaturation rate. We then correlated the delta-9 desaturation rate with the expression of scd1 protein and mRNA. We showed that C18:1 fatty acids controlled the expression of scd1 at the transcriptional level in HASMC, leading to an increase in scd1 mRNA content by trans-9 elaidic acid treatment, whereas a decrease in scd1 mRNA content was observed with cis-9 oleic acid and trans-11 vaccenic acid treatments. Altogether, this work highlights a differential capability of C18:1 fatty acid isomers to control scd1 gene expression, which presumes of different consequent effects on cell functions.

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Basic Lipid Science

O’Keefe¹,

Ambigaipalan²

2020

Bailey's Industrial Oil and Fat Products

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The role of lipids in health and diseases has been of great interest to scientists for many years. Lipids are defined largely based on their solubility in organic solvents and insolubility in water but they have a wide range of structures and biological effects. Fatty acids can be differentiated by chain length (short chain, medium chain, and long chain), unsaturation (saturated, monounsaturated, and polyunsaturated), the position of double bonds (omega 3, omega 6), and geometry of double bonds ( cis vs trans ). Increased intake of saturated fatty acids, trans fatty acids, and cholesterol have been shown to associate with coronary heart diseases. In this article, these factors in relation to health and diseases are discussed.

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trans-Fatty acids in the diet stimulate atherosclerosis

Cited by 42 publications

References 28 publications

The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells

Basic Lipid Science

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