The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary <i>trans</i> fat

Bassett, Chantal M. C.; McCullough, Richelle S.; Edel, Andrea L.; Patenaude, Amanda F.; LaVallee, Renee; Pierce, Grant N.

doi:10.1152/ajpheart.00958.2010

Cited by 55 publications

(49 citation statements)

References 41 publications

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“…Plasma fatty acids were quantified as described. [10][11][12][13]18 Enterolignans were deconjugated as previously described 22 followed by supported liquid extraction to isolate the liberated compounds. Analysis was by gas chromatography/mass spectrometry in microselected ion storage mode using a target ion of 180 for quantitation of both enterolignans.…”

Section: Methodsmentioning

confidence: 99%

“…The seed has a pleasant nutty flavor that can be eaten as is or incorporated into a number of food products. In animal trials, flaxseed has shown an unusually strong capacity to regulate CVD through its antiatherogenic effects, [9][10][11][12] anti-inflammatory properties, 11 improvements in vascular contractile function, 10 and a potent antiarrhythmic action during ischemic challenge. 13 Flaxseed may achieve these cardiovascular actions through its composition.…”

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confidence: 99%

“…It is high in dietary fiber, one of the richest sources of the short-chain ω-3 fatty acid α-linolenic acid (ALA), and it also contains lignans, which are potent antioxidants. [9][10][11][12][13] Although these data provide compelling evidence to justify the use of flaxseed in CVD, few studies have investigated its efficacy in a patient population. December 2013…”

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confidence: 99%

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Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive Patients

Rodriguez-Leyva

Weighell²,

Edel³

et al. 2013

Hypertension

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166

142

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Abstract-Flaxseed contains ω-3 fatty acids, lignans, and fiber that together may provide benefits to patients with cardiovascular disease. Animal work identified that patients with peripheral artery disease may particularly benefit from dietary supplementation with flaxseed. Hypertension is commonly associated with peripheral artery disease. The purpose of the study was to examine the effects of daily ingestion of flaxseed on systolic (SBP) and diastolic blood pressure (DBP) in peripheral artery disease patients. In this prospective, double-blinded, placebo-controlled, randomized trial, patients (110 in total) ingested a variety of foods that contained 30 g of milled flaxseed or placebo each day over 6 months. Plasma levels of the ω-3 fatty acid α-linolenic acid and enterolignans increased 2-to 50-fold in the flaxseed-fed group but did not increase significantly in the placebo group. Patient body weights were not significantly different between the 2 groups at any time. SBP was ≈10 mm Hg lower, and DBP was ≈7 mm Hg lower in the flaxseed group compared with placebo after 6 months.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive Patients

Rodriguez-Leyva

Weighell²,

Edel³

et al. 2013

Hypertension

Self Cite

166

142

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“…Upon arrival, rabbits were housed in individual cages in rooms with controlled temperatures, humidity, and a 12:12-h light-dark cycle. Animals were randomly allocated to experimental groups that were administered a regular rabbit chow (Nutrena, Nature Wise Performance Rabbit Formula), 1% cholesterol-supplemented diet (Ren's Pet Depot), or 10% flaxseed-supplemented diet, as previously described (3,7,22,23). Flaxseed was provided by Glanbia Nutritionals (Angusville, MB, Canada) and contained ϳ53% ALA. Flaxseed was ground, and the appropriate amount was added to moistened regular rabbit chow.…”

Section: Animals and Dietary Interventionsmentioning

confidence: 99%

“…Unlike drug therapy, n-3 PUFAs have fewer and milder side effects and are generally considered safe (37). Moreover, milled flaxseed has proven to be cardioprotective and antiatherogenic in animal models (7,22,23,44) as well as in clinical settings (50). However, although flaxseed can diminish the progression of atherosclerotic plaques, it is unclear if dietary supplementation with flaxseed can regress established atherosclerotic plaques.…”

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confidence: 99%

Effects of dietary flaxseed on atherosclerotic plaque regression

Francis

Deniset

Austria

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Francis AA, Deniset JF, Austria JA, LaValleé RK, Maddaford GG, Hedley TE, Dibrov E, Pierce GN. Effects of dietary flaxseed on atherosclerotic plaque regression. Am J Physiol Heart Circ Physiol 304: H1743-H1751, 2013. First published April 12, 2013 doi:10.1152/ajpheart.00606.2012.-Dietary flaxseed can retard the progression of atherosclerotic plaques. However, it remains unclear whether these antiatherogenic effects extend to plaque regression. In the present study, the therapeutic potential of dietary flaxseed on atherosclerotic plaque regression and vascular contractile function was evaluated using a novel rabbit model. Rabbits were randomly assigned to receive either a regular diet for 12 wk (group I) or a 1% cholesterol-supplemented diet for 4 wk followed by a regular diet for 8 wk (group II). The remaining experimental animals were treated as in group II but were fed for an additional 14 wk with either a regular diet (group III) or a 10% flaxseed-supplemented diet (group IV). Animals in group II showed clear evidence of plaque growth stabilization. Their vessels also exhibited significantly lower norepinephrine-induced contraction and an impaired relaxation response to acetylcholine compared with animals in group I. Dietary flaxseed supplementation resulted in a significant Ϸ40% reduction in plaque formation (P ϭ 0.033). Animals in both groups II and III displayed improved contraction and endothelium-dependent vessel relaxation. Dietary flaxseed is a valuable strategy to accelerate the regression of atherosclerotic plaques; however, flaxseed intervention did not demonstrate a clear beneficial effect on the vessel contractile response and endothelium-dependent vasorelaxation. atherosclerosis; flaxseed; heart disease; regression; vascular contractile function CARDIOVASCULAR DISEASE (CVD) is currently the leading cause of mortality worldwide. Its prevalence continues to increase despite improved treatments for atherosclerosis and will reach epidemic proportions within a decade due to the escalating predominance of sedentary, unhealthy lifestyles (32, 51, 52). Atherosclerosis is orchestrated by a complex array of molecular and cellular events commencing after endothelial injury. The resultant plaques may continue to progress, ultimately causing acute events such as myocardial infarction and stroke (23,32). Recently, it has been shown that atherosclerotic plaques are highly dynamic and that their progression can be slowed, stopped, and even reversed by drug intervention (6,18,43). For example, aggressive risk modification with statin drug therapy can remove lipids and necrotic material, restore endothelial function and viability, and prevent vascular smooth muscle cell proliferation and phenotype reversal, three processes involved in atherosclerotic plaque formation (18, 43).Akin to pharmaceuticals, functional foods can also be used to prevent and treat CVD. A functional food has a similar appearance to or may be a conventional food and may be consumed as part of a normal diet to have physiological benefits and/...

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Algal Derived Functional Lipids and their Role in Promoting Health

Terme

Chénais

Fournière

et al. 2021

Recent Advances in Micro and Macroalgal Processing

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Algae are organisms with an enormous biodiversity and contain manifold fatty acid molecular structures and ratios. This chapter presents information about the structure and distribution of fatty acids in algae whether microalgae or macroalgae. The parameters affecting lipid and fatty acid contents as well as distribution are also discussed. Methods for isolation and purification of fatty acids from algae to obtain highly pure fatty acid or fatty acid fractions with good overall yields are presented. Algal fatty acids are known as sources of bioactive compounds for health promotion and wellness. Lipid fractions and fatty acids act as actives or additives for cosmeceutical applications. For health promotion, preventive effects of n-3 polyunsaturated fatty acids on cardiovascular disease, metabolic syndrome and cancer are discussed. The role of n-3 fatty acids in cancer therapy and antiviral activities of lipids are also exposed. Furthermore, potential commercial application domains and concepts are discussed in this chapter.

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The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Cited by 55 publications

References 41 publications

Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive Patients

Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive Patients

Effects of dietary flaxseed on atherosclerotic plaque regression

Algal Derived Functional Lipids and their Role in Promoting Health

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