Trans fatty acids in hydrogenated fat inhibited the synthesis of the polyunsaturated fatty acids in the phospholipid of arterial cells

Kummerow, Fred A.; Zhou, Qi; Mahfouz, Mahmoud; Smiricky, M. R.; Grieshop, Christine M.; Schaeffer, David J.

doi:10.1016/j.lfs.2003.10.013

Cited by 67 publications

(50 citation statements)

References 43 publications

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“…However, the effects of these trans isomers on lipid profiles, metabolism of fatty acids and cardiovascular diseases have been intensively investigated in the past few decades. It was previously reported that TFAs suppress the production of proinflammatory prostaglandins via competitive inhibition of the activity of ⌬-6 desaturase, a key enzyme in the metabolic conversion of linoleic acid to arachidonic acid (2,5,11). That is, TFAs compete with linoleic acid as a substrate for ⌬-6 desaturase, reducing the availability of arachidonic acid for the production of inflammatory prostaglandins.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary <i>Trans</i> Fatty Acids Suppress the Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice

Sakai

Ire

Matoba

et al. 2009

J Nutr Sci Vitaminol

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SummaryAlthough several studies have shown that the type and degree of unsaturation of fatty acids alter the production of proinflammatory mediators, there have been few studies in which the effects of trans isomers on allergic responses were evaluated. NC/Nga (NC) mice raised in conventional conditions develop spontaneous atopic dermatitis-like lesions with IgE hyperproduction. We used this model to evaluate the effect of dietary trans fatty acids (TFAs) on the development of spontaneous dermatitis. NC mice were fed a 4 g TFAs/kg diet (4 g TFA), a 8 g TFAs/kg diet (8 g TFA) or a control diet with no TFA content for 10 wk. The dermatitis condition improved with the increasing intake of TFAs, and there was a significant difference from week 5 of the experimental period between the dermatitis conditions in 8 g TFA-fed mice and control mice. Production of total IgE was also suppressed in mice fed TFAs compared with that in control mice, correlating with the skin lesions. IFN-␥ , but not IL-4, production was significantly greater in TFA-fed mice that in control mice. Our results suggest that intake of TFAs suppresses the development of atopic dermatitis-like lesions in NC mice. Even though we observed a decreased production of IgE levels, mechanisms involved in the development of dermatitis-like lesions seem to be IL-4-independent.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that the type and degree of unsaturation as well as the trans configuration of dietary fatty acids affect lipid profiles, eicosanoid production and inflammatory responses, though the results are controversial (1)(2)(3)(4)(5). There is, however, limited information concerning trans isomers in allergic responses.…”

mentioning

confidence: 99%

Dietary <i>Trans</i> Fatty Acids Suppress the Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice

Sakai

Ire

Matoba

et al. 2009

J Nutr Sci Vitaminol

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“…This fermentation process is called biohydrogenation, and it results in TFAs that can be further metabolised in the mammary gland. Accurate estimations of fatty-acid compositions are vital not only for the definition of the nutrient composition of foods, but also to accurately determine treatment effects that can alter the fatty-acid composition of the foods (Ascherio, 2002;Burdge et al, 2005;Kummerow et al, 2004;Murrieta et al, 2003;Triantafillou et al, 2003).…”

Section: Studies In Animalsmentioning

confidence: 99%

Trans Fatty Acids and Human Health

Filip¹,

Vidrih²

2012

The Cardiovascular System - Physiology, Diagnostics and Clinical Implications

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“…O conteúdo de AGT é variável no leite materno, refletindo a ingestão dietética materna 42,58 . Depende principalmente do consumo recente de margarinas, gordura vegetal hidrogenada e produtos industrializados 42 .…”

Section: áCidos Graxos Trans No Leite Maternounclassified

“…Estudos experimentais confirmam uma relação dose-resposta direta entre a ingestão de AGT e a incorporação dos mesmos no leite materno, sendo transferidos para os filhotes por meio da lactação, vindo a aparecer no plasma e na aorta 58 .…”

Section: áCidos Graxos Trans No Leite Maternounclassified

Importância dos ácidos graxos essenciais e os efeitos dos ácidos graxos trans do leite materno para o desenvolvimento fetal e neonatal

et al. 2007

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A prática da amamentação tem grande impacto do ponto de vista da saúde pública, pois o leite materno é o melhor alimento a ser oferecido até o sexto mês de vida da criança. A fração lipídica do leite representa a maior fonte de energia para crianças e fornece nutrientes essenciais, tais como vitaminas lipossolúveis e ácidos graxos poliinsaturados (AGPI). Os ácidos graxos essenciais (AGE) linoléico (LA, 18:2n-6) e alfa-linolênico (ALA, 18:3n-3) são precursores dos ácidos graxos poliinsaturados de cadeia longa (AGPI-CL), incluindo os ácidos docosahexaenóico (DHA) e araquidônico (ARA). A qualidade dos lipídios no leite secretado está diretamente relacionada com a ingestão materna. Os AGPI-CL são importantes na proteção contra alergia e infecções, no processo visual e no desenvolvimento cognitivo na infância. O processamento industrial de alimentos introduziu os ácidos graxos trans (AGT) entre os nutrientes disponíveis à população. Os AGT podem interferir no metabolismo dos AGE, diminuindo a síntese de DHA e ARA. Portanto, nos parece relevante esclarecer a população sobre a importância de um aporte adequado de AGPI e reduzido de AGT durante o período de desenvolvimento pré e pós-natal.

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Trans fatty acids in hydrogenated fat inhibited the synthesis of the polyunsaturated fatty acids in the phospholipid of arterial cells

Cited by 67 publications

References 43 publications

Dietary <i>Trans</i> Fatty Acids Suppress the Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice

Dietary <i>Trans</i> Fatty Acids Suppress the Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice

Trans Fatty Acids and Human Health

Importância dos ácidos graxos essenciais e os efeitos dos ácidos graxos trans do leite materno para o desenvolvimento fetal e neonatal

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