Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement

Preliminary Results Suggest Tranexamic Acid is Safe and Effective in Arthroplasty Patients with Severe Comorbidities

“…In recent years the use of antifibrinolytic medications such as tranexamic acid (TXA) to decrease blood loss and transfusion has slowly gained popularity in orthopaedics [9,19]. Multiple prospective trials involving patients undergoing TJA have demonstrated a reduction in blood loss and transfusion rates with both TXA and e-aminocaproic acid (EACA) [1,2,4,8,17,20,21,25,26,28]. These results have been One of the authors (MWP) certifies that he has or may receive payments or benefits, in any one year, an amount in excess of USD 100,000 from DePuy (Warsaw, IN, USA), MAKO Surgical Corp (Ft Lauderdale, FL, USA), and Stryker Orthopaedics (Mahwah, NJ, USA).…”

Efectividad del ácido tranexámico en las pérdidas sanguíneas perioperatorias en la artroplastia de cadera: revisión sistemática de la literatura y metaanálisis

“…Las características de los estudios así como de los pacientes se pueden ver en las tablas 2 y 3, respectivamente. En la calificación de calidad, 13 estudios tuvieron una calificación de riesgo de sesgo de Cochrane de «bajo riesgo», y por consiguiente, 3 estudios tuvieron una calificación de riesgo de sesgo de calidad moderada 26 embudo para examinar el potencial sesgo de publicación entre los estudios con pacientes sometidos a artroplastia de cadera. La figura 2 muestra solo una mínima asimetría y algunos valores atípicos, lo que indica un sesgo de publicación leve para el desenlace de pérdida de sangre.…”

Tranexamic Acid Benefits Total Joint Arthroplasty Patients Regardless of Preoperative Hemoglobin Value

“…Antifibrinolytic medications inhibit bleeding from the surgical bed by reducing degradation of fibrin in newly formed thrombi [5]. Tranexamic acid has been shown to effectively decrease blood loss and postoperative transfusion rates in orthopedic patients without an increase in TEE [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Other studies investigating risk factors for postoperative transfusion found preoperative Hgb to be a significant predictor for subsequent packed red blood cell transfusion [23][24][25][26].…”

“…In recent years, the use of antifibrinolytic medications such as tranexamic acid (TXA) has led to reductions in intraoperative blood loss and postoperative transfusion. Both prospective trials and subsequent meta-analyses have demonstrated TXA's clinical efficacy without increasing thromboembolic events (TEE) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Given the demonstrable advantages of TXA, its use is becoming more widespread in patients undergoing TJA.…”