Tranexamic acid in total knee arthroplasty

Bailey, Craig R.

doi:10.1111/anae.15960

Cited by 5 publications

(4 citation statements)

References 26 publications

(33 reference statements)

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“…Open access with high bleeding, such as cardiac surgery, major orthopaedic surgery and traumatic bleeding. [12][13][14] These studies have confirmed the feasibility and tolerability of using TXA. 15 Furthermore, TXA has been found to possess anti-inflammatory properties.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 54%

Efficacy and safety of intravenous tranexamic acid in microscopic modified radical mastoidectomy: a study protocol for a prospective, randomised, double-blind controlled trial

Zhang,

Ding,

Feng

et al. 2024

BMJ Open

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IntroductionRadical mastoidectomy is a common procedure for chronic suppurative otitis media, typically performed under a microscope. The smooth operation is closely related to the clarity of the operative field. Our trial is designed to investigate whether the intravenous administration of tranexamic acid (TXA) can improve the clarity of the operative field, reduce the operative time, and increase surgeon satisfaction.Methods and analysisThis study is a prospective, randomised, double-blinded, controlled trial that aims to investigate the effects of TXA on patients with otitis media. The trial will include patients between the ages of 18 and 65 who will be randomly assigned to either the TXA group or the control group. In the TXA group, patients will receive 1 g of TXA diluted to 20 mL of normal saline before anaesthesia induction while the control group will receive 20 mL of normal saline. The primary outcome measure will be the Modena Bleeding Score, which will assess the clarity of the surgical field. Secondary outcomes will include the surgeon’s satisfaction with surgical conditions, operation time, laboratory measurements (prothrombin time, activated partial thromboplastin time, fibrin degradation products, D-dimer) and levels of inflammatory factors (such as IL-6) at 24 hours postoperatively. In addition, the incidence of general adverse reactions such as postoperative nausea, vomiting and dizziness; serious adverse events such as arterial and venous thromboembolism, myocardial infarction and epilepsy within 90 days will be compared between the two groups.Ethics and disseminationThe protocol was approved by the Ethics Committee of Peking University People’s Hospital (2021PHB173-001), on 19 July 2021. The trial results will be submitted for publication in a peer-reviewed journal.Trial registration numberChiCTR2100049183.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 54%

Efficacy and safety of intravenous tranexamic acid in microscopic modified radical mastoidectomy: a study protocol for a prospective, randomised, double-blind controlled trial

Zhang,

Ding,

Feng

et al. 2024

BMJ Open

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“…The application of TXA is mainly divided into oral, intravenous drip, water light needle injection, etc. Studies have shown that the onset time of intravenous drip therapy for melasma is faster than that of oral administration [9] . Some studies have also shown that the effect of water light needle injection of TXA+glutathione compound drug is better than that of intravenous injection of TXA [10] .…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Wu¹,

Wu²,

Ma³

et al. 2023

IJPS

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To study the efficacy and safety of tranexamic acid and hydroquinone cream with water light needle in the treatment of chloasma, and to provide clinical reference for the treatment of Chloasma is the main objective. A total of 230 patients with chloasma admitted to Fuyang Maternal and Child Health Hospital of Hangzhou from March 2019 to August 2022 were selected and divided into study group (n=115) and control group (n=115) according to the odd and even number of treatment. The study group received tranexamic acid injection with water-light needle and hydroquinone cream. In the control group, tranexamic acid was injected with water light needle and asiaticoside ointment was applied. After the treatment, the effective rate, melasma area and severity index, dermatology life quality index, recurrence rate and incidence of adverse drug reactions were compared between the two groups. After the treatment, the total effective rate of the study group was 94.78 %, which was significantly higher than 80.87 % of the control group (p<0.05). The melasma area and severity index and dermatology life quality index scores of the study group were lower than those of the control group (p<0.05), and the recurrence rate and adverse drug reaction rate of the study group were lower than those of the control group (p<0.05). Tranexamic acid and hydroquinone cream with water light needle in the treatment of melasma has obvious curative effect, high safety, low recurrence rate and high patient satisfaction, significantly enhance the quality of life and it is worthy of drug promotion.

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“…There are also inconsistent results in terms of transfusion rates and drainage in previous articles, with [3][4][5], which may be related to whether tranexamic acid was used intraoperatively. Tranexamic acid reduces bleeding and transfusion requirements in the perioperative period [23,24].The transfusion rate in the study by Dikmen İ et al [4] was partly due to a decrease in the use of tranexamic acid.In addition,there is a difference in the results of drainage ow between Dikmen İ et al and Batmaz AG et al [3,5]. We compared them and found that the time of drainage tube removal was different, and since drainage ow increases with time, it is closely related to the time of removal and also to the use of perioperative anticoagulants [25,26].…”

Section: Discussionmentioning

confidence: 96%

Effect of bone cement sealing of the intramedullary femoral canal on coagulation status after total knee arthroplasty: a retrospective thromboelastography study

Wang

Zhang

Sun

et al. 2023

Preprint

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Background: The main objective of this study was to investigate whether the use of bone cement in total knee arthroplasty (TKA) has an effect on postoperative coagulation status and bleeding METHODS: 148 patients who underwent unilateral TKA between September 2019 and February 2023 were collected and divided into Bone and Cement&Bone groups according to whether bone cement was used to seal the bone medullary canal intraoperatively. Routine blood and thromboelastography(TEG) examinations were performed on the day before, the first day and the seventh day after surgery; postoperative bleeding, drainage, transfusion rate and the number of people suffering from deep venous thrombosis (DVT) were recorded. RESULTS: There were no significant differences between the two groups in terms of baseline clinical characteristics before surgery（p>0.05）。In terms of TEG indicators, the CI of the Bone&Cement group was lower than that of the Bone group on the first postoperative day and on the seventh postoperative day (p<0.005). The CI of patients in the Bone group on the first postoperative day was lower than that of the preoperative day (p<0.05); In terms of blood loss, the total blood loss and occult blood loss were lower in the Bone&Cement group than in the Bone group (p< 0.05). In addition, there was no significant difference in the incidence of postoperative drainage (p:0.255), transfusion rate (p:0.286) and DVT (p:0.576) between the two groups CONCLUSION: Blocking the intramedullary canal of the femur with bone cement during TKA improves relative postoperative hypocoagulation and reduces postoperative blood loss, although there is no significant effect on transfusion rates, drainage and DVT, but the use of bone cement is clinically beneficial to patients. TRIAL REGISTRATION: ChiCTR2100051502, 2021/09/24

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Tranexamic acid in total knee arthroplasty

Abstract: Twitter: @DocCRBailey When we administer any medication, it should be safe, effective and affordable. Tranexamic acid (TXA) was first introduced as a therapeutic drug in the early 1960s [1], so we now have 60 years' experience in its use. It is a synthetic

Cited by 5 publications

References 26 publications

Efficacy and safety of intravenous tranexamic acid in microscopic modified radical mastoidectomy: a study protocol for a prospective, randomised, double-blind controlled trial

Efficacy and safety of intravenous tranexamic acid in microscopic modified radical mastoidectomy: a study protocol for a prospective, randomised, double-blind controlled trial

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Effect of bone cement sealing of the intramedullary femoral canal on coagulation status after total knee arthroplasty: a retrospective thromboelastography study

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