Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Abstract

Received the first dose of study drug 4612 (97.0) (96.7) Received the second dose of the study drug 4586 (96.4) (96.5) Received both doses of the study drug 4581 (96.3) (96.3) no. = number; % = percentage

Haematological management of major haemorrhage: a British Society for Haematology Guideline

“…133 Evidence that TXA reduces blood transfusion needs in surgery has been available for many years, 134 including the recent POISE-3 trial, which reported a significantly lower incidence of a composite bleeding outcome in non-cardiac surgery patients receiving TXA. 135 Information on doses of TXA as prophylaxis prior to surgery with anticipated moderate blood loss is also provided in the National Institute for Health and Care Excellence transfusion guidelines; higher doses have no greater haemostatic effect and may be associated with seizures. 136,137 Emergency planning and mass casualty events National emergency planning requires healthcare organisations to assess that they can deal with incidents while maintaining critical services.…”

Major haemorrhage: putting evidence into practice

“…The guideline makes 38 recommendations based on 158 key references in this rapidly evolving field. Multiple trials have been published since the 2015 guideline: WOMAN, 2 CRASH‐3, 3 PAMPer, 4 COMBAT, 5 FIBRES, 6 HALT‐IT, 7 iTACTIC, 8 RePHILL, 9 and POISE‐3 10 (Table 1). The guideline summarises and digests the literature, which will assist with education, facilitate the development of haemorrhage protocols, and material for knowledge translation.…”

Management of Antiplatelet Therapy in Patients with Coronary Stents Undergoing Noncardiac Surgery

“…13 Tranexamic acid reduces perioperative bleeding, but the safety of this therapy in patients with coronary stents remains uncertain. 15 Platelet function testing to predict perioperative bleeding risks and guide the timing of noncardiac surgery has not been studied in clinical trials. 9 Novel approaches for prediction and management of perioperative risk of bleeding and thrombosis are necessary to reduce complications.…”