Tramadol 2.5 mg·kg−1 appears to be the optimal intraoperative loading dose before patient-controlled analgesia

Pang, Wei‐Wu; Wu, Hurng‐Sheng; Tung, Chien-Chiung

doi:10.1007/bf03020186

Cited by 21 publications

(9 citation statements)

References 9 publications

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“…This is not surprising considering that those trials differed in their study protocols including studied subjects, type of surgeries, drugs used for anaesthesia, other analgesics allowed besides tramadol, time, dose and mode of administration of drugs. In our study we have chosen moderately painful surgeries and we have selected the lower intra-operative dose of tramadol considered appropriate for postoperative pain management [14,15] .…”

Section: Discussionmentioning

confidence: 99%

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Vale¹,

Oliveira²,

Assunção³

et al. 2011

Pharmacology

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Tramadol, a central analgesic acting on serotonin neurotransmission, is often co-used with ondansetron, a 5-HT₃ antagonist, for the management of postoperative pain to decrease nausea and vomiting. The aim of the study is to test the hypothesis that this drug combination raises tramadol requirement by patient-controlled analgesia (PCA). Forty patients undergoing hernioplasty or thyroidectomy were enrolled in a randomized, controlled study and allocated to receive ondansetron 4 mg i.v. (n = 20) or saline (n = 20). At 0, 1, 2, 4 and 24 h of PCA, tramadol consumption was evaluated. Tramadol consumption (mg × kg^–1 × h^–1) was higher in the ondansetron group at the 2-hour time point compared to the control group (0.24 ± 0.1 vs. 0.17 ± 0.16; p = 0.01). Our study suggests that ondansetron acutely reduces the analgesic efficacy of tramadol.

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Section: Discussionmentioning

confidence: 99%

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Vale¹,

Oliveira²,

Assunção³

et al. 2011

Pharmacology

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“…One study also showed that the time to first analgesic request was significantly longer with parecoxib compared with placebo [14] (see Table 1). [19] Inconclusive Ropivacaine via femoral catheter [117] NS Bupivacaine via femoral catheter [35] NS Spinal diamorphine [42] NS Spinal morphine [43] NS Lumbar epidural ketamine [52] NS Lumbar epidural ropivacaine [50,53] Inconclusive Route and method of drug administration IV vs IM strong opioid [23] NS IV PCA vs IM strong opioid [24] IM superior for moderate pain scores Surgical approaches Medial trivector approach [61], Subvastus approach [62], vs parapatellar approach NS Posterior cruciate ligament (PCL) surgery during TKA: different surgical approaches [63] PCL released surgery inferior to other approaches Midvastus approach vs medial parapatellar approach [64] Midvastus superior at rest and on movement…”

Section: Cox-2-selective Inhibitorsmentioning

confidence: 99%

A procedure‐specific systematic review and consensus recommendations for postoperative analgesia following total knee arthroplasty

Fischer¹,

Simanski²,

Sharp³

et al. 2008

Anaesthesia

264

218

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SummaryThe PROSPECT Working Group, a collaboration of anaesthetists and surgeons, conducts systematic reviews of postoperative pain management for different surgical procedures (http://www.postoppain.org). Evidence‐based consensus recommendations for the effective management of postoperative pain are then developed from these systematic reviews, incorporating clinical practice observations, and transferable evidence from other relevant procedures. We present the results of a systematic review of pain and other outcomes following analgesic, anaesthetic and surgical interventions for total knee arthroplasty (TKA). The evidence from this review supports the use of general anaesthesia combined with a femoral nerve block for surgery and postoperative analgesia, or alternatively spinal anaesthesia with local anaesthetic plus spinal morphine. The primary technique, together with cooling and compression techniques, should be supplemented with paracetamol and conventional non‐steroidal anti‐inflammatory drugs or COX‐2‐selective inhibitors, plus intravenous strong opioids (high‐intensity pain) or weak opioids (moderate‐ to low‐intensity pain).

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“…Tramadol addiction and abuse is much less than morphine. The only important side effect of Tramadol is nausea and vomiting that can be prevented by taking anti-nausea drugs such as metoclopramide [25][26][27]. There is no standard method for local infiltration around the wound in operations such as appendectomy.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Local Tramadol Injection in Post Appendectomy Pain

Khazaei

Kalati

Borumand

et al. 2015

Zahedan J Res Med Sci

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Background: Tramadol is a weak synthetic opioid with an effective analgesic result. This medicine has both systemic and local anesthetic effects on peripheral nerve system. Objectives: The purpose of this study is to compare post-appendectomy analgesic effect of subcutaneous injection of tramadol with normal saline. Patients and Methods: This double blind study was conducted on 60 patients over 15 years old, who were randomly divided in two equal groups, i.e. tramadol and normal saline. After repairing fascia in appendectomy, 100 mg of tramadol that was diluted up to 10 mL and 10 mL normal saline were used for subcutaneously injection around the surgical wound in experimental and control groups, respectively. Then, the intensity of pain was recorded in the recovery room, and 6 and 24 hours after operation, based on NRS. In addition, number of petidine (with a dosage of 25 milligram) administered in the same period, in case of severe and moderate pain, was recorded. At the end, the intensity of pain during the mentioned time and the average use of petidine in two groups were compared. Results: The average of severe pain in recovery time (3.08 ± 1.44 versus 5.36 ± 2.02), 6 (3.36 ± 1.22 versus 5.36 ± 1.38) and 12 (2.08 ± 0.76 versus 3.08 ± 1.15) hours after operation was lower in tramadol group (P = 0.0001). Moreover, the amount of consumed petidine in the same period of time showed a clear reduction (P < 0.05). Conclusions: Subcutaneous injection of tramadol is an appropriate choice for reduction of post-appendectomy pain and decreasing need for potent narcotic painkillers. This treatment method can decrease side effects of using potent narcotics after appendectomy.

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Tramadol 2.5 mg·kg−1 appears to be the optimal intraoperative loading dose before patient-controlled analgesia

Cited by 21 publications

References 9 publications

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

A procedure‐specific systematic review and consensus recommendations for postoperative analgesia following total knee arthroplasty

The Effect of Local Tramadol Injection in Post Appendectomy Pain

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