Trajectories of muscle quantity, quality and function measurements in hospitalized older adults

Welch, Carly; Greig, Carolyn; Lewis, Danielle; Majid, Zeinab; Masud, Tahir; Moorey, Hannah; Pinkney, Thomas; Stanley, Benjamin; Jackson, Thomas

doi:10.1111/ggi.14366

Cited by 8 publications

(18 citation statements)

References 28 publications

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“…In fact, short- to medium-term interventions, such as interventions that last 8–10 wks, do not alter IMAT 24,27 . Moreover, a similar design to the present study was reported to examine muscle mass and quality (identified by the phase angle) using the impedance method, but as in the present study, insufficient improvement in skeletal muscle mass was obtained 28 . Thus, it is possible that exercise does not actually reduce IMAT, but it prevents it from increasing 18 .…”

Section: Discussionmentioning

confidence: 51%

“…24,27 Moreover, a similar design to the present study was reported to examine muscle mass and quality (identified by the phase angle) using the impedance method, but as in the present study, insufficient improvement in skeletal muscle mass was obtained. 28 Thus, it is possible that exercise does not actually reduce IMAT, but it prevents it from increasing. 18 The same is true for skeletal muscle mass, 27 and long-term interventions are essential for maintaining muscle mass.…”

Section: Discussionmentioning

confidence: 99%

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The trajectory of abdominal skeletal muscle changes during cardiac rehabilitation in patients with aortic disease

Kamiya

Kitamura

Hamazaki

et al. 2023

Am J Phys Med Rehabil

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Objective This prospective study focused on routine computed tomography (CT) imaging for aortic disease management and evaluated the trajectory of skeletal muscle changes through inpatient and outpatient cardiac rehabilitation. Design Prospective observational study included patients who underwent abdominal CT three times (baseline, post-acute care, and follow-up). The area and density of the all-abdominal and erector spine muscles and intramuscular adipose tissue (IMAT) were measured. A generalized linear model with patients as random effects was used to investigate skeletal muscle changes. Results Thirty-nine patients completed outpatient cardiac rehabilitation, and 60 were incomplete. Skeletal muscle area significantly decreased from baseline to the follow-up period only in the incomplete rehabilitation group. Skeletal muscle density significantly decreased from baseline to post-acute care and increased at the follow-up period, but only patients who completed rehabilitation showed recovery up to baseline at the follow-up period. These trajectories were more pronounced in the erector spine muscle. IMAT showed a trend of gradual increase, but only the incomplete rehabilitation group showed a significant difference from baseline to the follow-up period. Conclusion The density of skeletal muscle may reflect the most common clinical course; skeletal muscle area and IMAT are unlikely to improve positively, and their maintenance seemed optimal.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

The trajectory of abdominal skeletal muscle changes during cardiac rehabilitation in patients with aortic disease

Kamiya

Kitamura

Hamazaki

et al. 2023

Am J Phys Med Rehabil

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“…Welch et al, reported decreasing SMM after one week of hospitalization, but it was not significant [36]. Only Aarden et al compared muscle index, and found that there was no change in mean of skeletal muscle mass index PLOS ONE [32,34,36] demonstrated that hand grip strength of participants reduced on discharge, however not adequate to be statistically significant. Aarden et al [31] reported slight increase (0.1kg) in mean hand grip strength on discharge, but statistical significance was not reported.…”

Section: Sarcopenia During Hospitalizationmentioning

confidence: 99%

“…The mean age for all the participants were 78.1 years. The studies involved participants recruited from geriatric medicine wards [31,35], general medical wards [32,[34][35][36], surgical wards [36] and cardiology wards [31,33] Mean duration of stay for the study participants were 14 days. Details of demographic particulars of included studies are presented in Table 1.…”

Section: Included Studiesmentioning

confidence: 99%

Incident sarcopenia in hospitalized older people: A systematic review

et al. 2023

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Hospitalization has been associated with the development of sarcopenia. This study aimed to examine the new incidences of hospital sarcopenia, associated risk factors and health outcomes, as defined by internationally recognized diagnostic criteria in hospitalized older people. Pre-defined search terms were run through five databases. Six studies that assessed sarcopenia on two separate time points during hospitalization on older inpatients were included. Prevalence of sarcopenia varied from 14.1% to 55% depending on diagnostic criteria and cut-off points used. New sarcopenia occurred between 12% to 38.7% patients following hospitalization. Risk factors were older age, longer duration of bed rest, lower baseline body mass index, cognitive impairment and activities of daily living disability. None of the studies reported health outcomes associated with newly developed sarcopenia in hospital.

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“…Understanding acute changes in muscle and performance measures in a heterogeneous population of older hospitalised patients relies on sensitivity to change in these measures. There are few studies on such changes that are still poorly understood [42].…”

Section: Diagnosing Sarcopenia In Acute Carementioning

confidence: 99%

Acute Sarcopenia

Montero‐Errasquín

Cruz-Jentoft²

2023

Gerontology

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Sarcopenia is currently understood as an organ insufficiency. However, the distinction of acute and chronic sarcopenia as different categories, which makes sense in this conceptual framework, is still evolving. The first set of modern definitions of sarcopenia only considered chronic sarcopenia. However, research showed that function in acute care settings differs from the loss that evolves slowly over months or years, and this fact is starting to permeate modern definitions. The updated version of the EWGSOP sarcopenia identifies acute and chronic sarcopenia as subcategories. Different studies have reported rates of incident sarcopenia in hospitalized older patients around 15% to 20%, which adds to the prevalent sarcopenia present on admission. Diagnosing sarcopenia in acute settings carries specific challenges related to the patients, the acute condition and limitations in the use of diagnostic tests for muscle mass, muscle strength and physical performance. Prevention and management of acute sarcopenia rely on exercise during admission, but the quality of evidence is still low. Nutrition intervention and drugs may have a role, but more research is needed.

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Trajectories of muscle quantity, quality and function measurements in hospitalized older adults

Cited by 8 publications

References 28 publications

The trajectory of abdominal skeletal muscle changes during cardiac rehabilitation in patients with aortic disease

The trajectory of abdominal skeletal muscle changes during cardiac rehabilitation in patients with aortic disease

Incident sarcopenia in hospitalized older people: A systematic review

Acute Sarcopenia

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