Trajectories of Functioning Into Emerging Adulthood Following Treatment for Adolescent Depression

Peters, Amy T.; Jacobs, Rachel H.; Feldhaus, Claudia; Henry, David B.; Albano, Anne Marie; Langenecker, Scott A.; Reinecke, Mark A.; Silva, Susan G.; Curry, John F.

doi:10.1016/j.jadohealth.2015.09.022

Cited by 25 publications

(20 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, effective intervention for depression among adolescents can promote long-lasting improvements in global functioning during the transition to adulthood [62]. The adolescent brain, particularly the networks supporting cognitive control, continue to develop through adolescence and into early adulthood [63].…”

Section: Discussionmentioning

confidence: 99%

Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI

et al. 2016

Self Cite

View full text Add to dashboard Cite

This pilot randomized control trial was designed to examine whether Rumination-Focused Cognitive Behavior Therapy (RFCBT) reduces rumination and residual depressive symptoms among adolescents with a history of Major Depressive Disorder (MDD) who are at risk for relapse. We also examined whether these changes in symptoms were associated with changes in functional connectivity of the posterior cingulate cortex (PCC), a key node in the default mode network (DMN). Thirty-three adolescents (ages 12–18) were randomized to eight weeks of RFCBT or an assessment only (AO) control. Twenty two adolescents successfully completed fMRI scans pre- and post-intervention. Adolescents were recruited from the clinic and community and met criteria for at least one previous episode of MDD and were currently in full or partial remission. An Independent Evaluator interviewed parent and child before and after the eight-week intervention. The left PCC (-5, -50, 36) seed was used to probe resting state functional connectivity of the DMN. Adolescents who received RFCBT demonstrated reduced rumination (F = -2.76, df = 112, p < .01, 95% CI [-4.72,-0.80]) and self-report depression across eight weeks (F = -2.58, df = 113, p < .01, 95% CI [-4.21, -0.94]). Youth who received RFCBT also demonstrated significant decreases in connectivity between the left PCC and the right inferior frontal gyrus (IFG) and bilateral inferior temporal gyri (ITG). Degree of change in connectivity was correlated with changes in self-report depression and rumination. These data suggest that rumination can be reduced over eight weeks and that this reduction is associated with parallel decreases in residual depressive symptoms and decreased functional connectivity of the left PCC with cognitive control nodes. These changes may enhance the ability of vulnerable youth to stay well during the transition to adulthood.Trial Registration: ClinicalTrials.gov NCT01905267

show abstract

Section: Discussionmentioning

confidence: 99%

Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Tailoring new screening tools and interventions to prevent depression by incorporating types of life events may prove to be a successful strategy. The different types of life events may provide clues to the adolescent’s environment that should be taken into account [85]. For example, a review of school-wide interventions for the prevention of depression concludes that universal school-wide interventions may not be efficacious or efficient because they focus on the individual without looking at the environmental changes that are needed to prevent the development of depression [86].…”

Section: Discussionmentioning

confidence: 99%

Association of Types of Life Events with Depressive Symptoms among Puerto Rican Youth

Jaschek

Carter‐Pokras

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

The main objective of this study was to examine the association between four types of adverse life events (family environment, separation, social adversity, and death) and the development of depressive symptoms among Puerto Rican youth. This was a secondary analysis using three waves (2000–2004) of interview data from the Boricua Youth Study of 10–13 year old Puerto Rican youth residing in New York and Puerto Rico with no depressive symptoms at baseline (n = 977). Depressive symptoms increased with an increase in social adversity, separation, death, and death events. Youth support from parents was a significant protective factor for all adverse events and parent coping was a protective factor in social adversity events. Relying on standard diagnostic tools is ideal to identify youth meeting the criteria for a diagnosis of depression but not useful to detect youth who present with subclinical levels of depression. Youth with sub-clinical levels of depression will not get treated and are at increased risk of developing depression later in life. Adverse life events are potentially relevant to use in conjunction with other screening tools to identify Puerto Rican youth who have subclinical depression and are at risk of developing depression in later adolescence.

show abstract

“…Few studies have examined treatments for the prevention of relapse or recurrence, despite these youths' high risk. Even more concerning is the growing evidence for a cumulative neurobiological burden of repeated episodes of depression [9,10] and the potential for worse outcomes if treatment is delayed [11]. To increase efficacy of relapse prevention services for youth, we must fully explicate the specific behavioral and brain mechanisms contributing to depressive resilience and relapse.…”

Section: Introductionmentioning

confidence: 99%

Malleability of rumination: An exploratory model of CBT-based plasticity and long-term reduced risk for depressive relapse among youth from a pilot randomized clinical trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Early-onset depression is associated with increased lifespan chronicity, suicidality, and the functional burdens associated with recurrent episodes. Reduction of these negative longterm outcomes requires an understanding of what interventions reduce vulnerabilities or ameliorate their associated neural patterns. Rumination-Focused Cognitive Behavior Therapy (RFCBT), an evidence-based treatment which directly targets a well-known risk for depressive relapse (i.e., ruminative habit), has shown preliminary success for reducing relapse rates among adolescents and adults in remission from Major Depressive Disorder (rMDD). In the current pilot study, clinical outcomes and neuroimaging predictors are explored over two years following a randomized controlled trial of eight weeks of RFCBT (n = 17) or Assessment Only (AO; n = 16) to prevent depressive relapse among adolescents. Baseline neural activation during a rumination induction task, neural change during treatment, and treatment group are examined as predictors of relapse. Regions selected were based upon hyperactivation patterns in rMDD compared to healthy adolescents, and occurred largely in default mode, somatomotor, visual and salience network regions. Twenty-five adolescents successfully completed quality fMRI scans at Baseline and after eight weeks of RFCBT or AO. RFCBT-treated youth maintained lower depression scores over the two-year period, relapsed at slower and less frequent rates, and were hospitalized less often for suicidality than AO. Although both groups reported lower ruminative tendencies after one year, at two-year follow-up, RFCBT maintained reductions whereas AO reported a return of ruminative tendencies. Adolescents who demonstrated higher activation at Baseline in default mode and limbic regions during rumination induction reported reduced depressive symptoms over the follow-up period. These data offer preliminary evidence that targeting rumination can stave off depressive relapse among vulnerable adolescents, and

show abstract

Trajectories of Functioning Into Emerging Adulthood Following Treatment for Adolescent Depression

Cited by 25 publications

References 38 publications

Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI

Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI

Association of Types of Life Events with Depressive Symptoms among Puerto Rican Youth

Malleability of rumination: An exploratory model of CBT-based plasticity and long-term reduced risk for depressive relapse among youth from a pilot randomized clinical trial

Contact Info

Product

Resources

About