Trajectories of cognitive decline in different types of dementia

Smits, Lieke; Harten, Argonde C. van; Pijnenburg, Yolande A.L.; Koedam, Esther; Bouwman, Femke H.; Sistermans, Nicole; Reuling, I. E. W.; Prins, Niels D.; Lemstra, Afina W.; Scheltens, Philip; Flier, Wiesje M. van der

doi:10.1017/s0033291714002153

Cited by 99 publications

(98 citation statements)

References 33 publications

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“…Therefore it is sensible to include other cognitive domains (e.g. executive functions, attention, visuospatial functioning, language) in SCD assessments (34, 35). For example, recent work by Smart and collaborators demonstrated decrements in attention and decision-making, respectively, in persons with SCD as compared to healthy older controls (36, 37).…”

Section: Resultsmentioning

confidence: 99%

Implementation of subjective cognitive decline criteria in research studies

Molinuevo

Rabin

Amariglio

et al. 2016

Alzheimer's & Dementia

424

447

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INTRODUCTION Subjective Cognitive Decline (SCD) manifesting prior to clinical impairment could serve as a target population for early intervention trials in Alzheimer’s disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. METHODS Members of the SCD-I met to identify and agree upon topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. RESULTS Topics included SCD inclusion and exclusion criteria, together with the informant’s role in defining SCD presence and the impact of demographic factors. DISCUSSION Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

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Section: Resultsmentioning

confidence: 99%

Implementation of subjective cognitive decline criteria in research studies

Molinuevo

Rabin

Amariglio

et al. 2016

Alzheimer's & Dementia

424

447

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“…processing speed and executive impairment) are most commonly associated with late-life depression (28) and other forms of dementia (29). We found similar results with naMCI as the outcome suggesting that the sex difference in how depressive symptoms relate to risk of cognitive impairment also applies to non-memory domains and a risk of dementia.…”

Section: Resultsmentioning

confidence: 99%

Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment

Sundermann

Katz

Lipton

2017

The American Journal of Geriatric Psychiatry

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BACKGROUND The relationship between depressive symptoms and subsequent cognitive impairment in older adults is controversial. Sex differences and the differences in the method of categorizing depressive symptoms may contribute to the inconsistencies. OBJECTIVE To examine the effect of severity of baseline depressive symptoms on risk of incident amnestic mild cognitive impairment (aMCI) separately in men and women. METHODS Community-dwelling and cognitively healthy older adults (aged≥70 years) from the Einstein Aging Study completed the 15-item Geriatric Depression Scale (GDS-15) at their baseline visit. Participants were categorized into “no or low symptoms” (GDS-15 score=0–2), “mild symptoms” (GDS-15 score=3–5) and “moderate/severe symptoms” (GDS-15 score>6) groups. Sex-stratified Cox proportional hazards models, adjusted for age, education, and antidepressant medication, estimated hazard ratios (HR) and 95% confidence intervals (CIs) for incident aMCI as a function of depressive symptoms group. RESULTS We followed 572 women (mean age=78) and 345 men (mean age=77) for 4.2 years on average (range=1.0–14.6 years). Ninety women and 64 men developed aMCI during follow-up. Cox models revealed that compared to no/low depressive symptoms, mild symptoms were associated with a two times greater risk of developing aMCI in men (HR=2.22, 95%CI=1.26–3.89) but not in women (HR=1.26; 95%CI=0.77–2.06). Conversely, moderate/severe depressive symptoms were associated with a two times greater risk of developing aMCI in women (HR=1.99, 95%CI=1.05–3.77) but not in men (HR=0.28, 95%CI=0.04–2.11) possibly due to low statistical power in this subgroup. CONCLUSIONS Results indicate that mild depressive symptoms in men and moderate/severe symptoms in women may represent a marker for future cognitive impairment.

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“…By contrast, Wilson et al, using data from a longitudinal cohort study of 823 older adults, reported that loneliness was linked to a more rapid decline in semantic memory rather than episodic memory. On the other hand, the focus of most studies on single cognitive screening tests or aggregated results across diverse cognitive tasks might limit our potential to explore trajectories of different cognitive profiles . Markers of fluid abilities (eg, episodic memory) that are known to decline over the lifespan and to be impaired at the earlier stages of neurocognitive disorders might be more sensitive to the effects of loneliness and social isolation than those of crystallized abilities (eg, verbal fluency).…”

Section: Introductionmentioning

confidence: 99%

Are loneliness and social isolation associated with cognitive decline?

Lara

Caballero

Rico-Uribe

et al. 2019

Int J Geriat Psychiatry

248

169

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Objective This study aimed to examine the association of loneliness and social isolation on cognition over a 3‐year follow‐up period in middle‐ and older‐aged adults. Methods Data from a Spanish nationally representative sample were analyzed (n = 1691; aged 50 years or older). Loneliness, social isolation, and cognition (immediate recall, delayed recall, verbal fluency, forward digit span, backward digit span, and a composite cognitive score) were assessed both at baseline and at follow‐up. Adjusted generalized estimating equations models were performed. Results Loneliness was significantly associated with lower scores in the composite cognitive score, immediate and delayed recall, verbal fluency, and backward digit span (B = −0.14 to B = −3.16; P < .05) and with a more rapid decline from baseline to follow‐up in two out of six cognitive tests. Higher social isolation was associated with lower scores in the composite cognitive score, verbal fluency, and forward digit span (B = −0.06 to B = −0.85; P < .05). The effect of loneliness and social isolation on cognition remained significant after the exclusion of individuals with depression. Conclusions Both loneliness and social isolation are associated with decreased cognitive function over a 3‐year follow‐up period. The development of interventions that include the enhancement of social participation and the maintenance of emotionally supportive relationships might contribute to cognitive decline prevention and risk reduction.

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Trajectories of cognitive decline in different types of dementia

Abstract: We show cognitive trajectories of different types of dementia. These estimations of natural disease course have important value for the design of clinical trials as neuropsychological measures are increasingly being used as outcome measures.

Cited by 99 publications

References 33 publications

Implementation of subjective cognitive decline criteria in research studies

Implementation of subjective cognitive decline criteria in research studies

Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment

Are loneliness and social isolation associated with cognitive decline?

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