Traitement de la leishmaniose cutanée par le métronidazole : étude de 30 cas

Belhadjali, H.; Elhani, Ichrak; Youssef, M.; Babba, Hammouda

doi:10.1016/j.lpm.2008.09.008

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…However, there are few reports focusing on its antileishmanial effects. It is used against infections presented by cutaneous leishmaniasis [20]. To the best of our knowledge, no previous study of the antileishmanial activity of S. clandestina extracts has been reported.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antileishmanial Activity of Extracts from Endemic Moroccan Medicinal Plant Salvia verbenaca (L.) Briq. ssp verbenaca Maire (S. clandestina Batt. non L)

Et-Touys

Fellah

Sebti

et al. 2016

EJMP

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Section: Introductionmentioning

confidence: 99%

In vitro Antileishmanial Activity of Extracts from Endemic Moroccan Medicinal Plant Salvia verbenaca (L.) Briq. ssp verbenaca Maire (S. clandestina Batt. non L)

Et-Touys

Fellah

Sebti

et al. 2016

EJMP

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“…Some studies on the treatment of experimental cutaneous leishmaniasis have demonstrated a significant reduction in lesion size and in the number of parasites via histological examination. It is also a drug without major side effects and with easy administration and low cost, which reinforces the idea of using this drug in the treatment of cutaneous leishmaniasis (68)(69)(70).…”

Section: Antiparasitic Drugsmentioning

confidence: 55%

Leishmaniasis treatment update of possibilities for drug repurposing

Torres-Santos¹

2018

Front Biosci

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The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.

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“…L'effet du métronidazole est attesté depuis la première étude mondiale au Mexique sur Leishmania mexicana, malgré que ce produit ne constitue pas une indication dans le traitement de la leishmaniose [11]. Les résultats obtenus à partir de cette étude mexicaine ont incité d'autres travaux sur le Leishmania major avec des résultats variables [11][12][13][14]. Certains auteurs défendent l'abstention thérapeutique, étant donné l'évolution vers la guérison spontanée dans plus de la moitié des cas en moins de 3 mois [15].…”

Section: Discussionunclassified

Lésion ulcérocroûteuse de l’angle interne de l’œil droit : la leishmaniose cutanée en est une cause

Salissou¹,

Doulla²,

Ouedraogo³

et al. 2018

Our Dermatol Online

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A crushing ulcerous lesion of the internal angle of the A crushing ulcerous lesion of the internal angle of the right eye: Cutaneous leishmaniasis is one of the causes right eye: Cutaneous leishmaniasis is one of the causes ABSTRACTNiger is a tropical country where leishmaniasis is endemic. The first case was reported in 1911. Leishmania major is practically the pathogen found in Niger, a country lying between 8° and 20° north latitudes from the Atlantic to the Chadian border. We report a case of cutaneous leishmaniasis in the type of ulcerative lesion, characterized by its localization at the internal angle of the right eye posing a diagnostic problem. The diagnosis of leishmaniasis was made by parasitological examination. Anatomipathologic examination eliminated cutaneous tuberculosis, pyogenic granuloma, molluscum contagiosum and basal cell epithelioma. Metronidazole management has accelerated healing. Thus in a tropical country, in front of any chronic, painless ulcerative lesion and resistant to all therapeutics, the diagnosis of cutaneous leishmaniasis must be evoked, for a consequent management after confirmation.

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Traitement de la leishmaniose cutanée par le métronidazole : étude de 30 cas

Cited by 10 publications

References 4 publications

In vitro Antileishmanial Activity of Extracts from Endemic Moroccan Medicinal Plant Salvia verbenaca (L.) Briq. ssp verbenaca Maire (S. clandestina Batt. non L)

In vitro Antileishmanial Activity of Extracts from Endemic Moroccan Medicinal Plant Salvia verbenaca (L.) Briq. ssp verbenaca Maire (S. clandestina Batt. non L)

Leishmaniasis treatment update of possibilities for drug repurposing

Lésion ulcérocroûteuse de l’angle interne de l’œil droit : la leishmaniose cutanée en est une cause

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