Training following unilateral cervical spinal cord injury in rats affects the contralesional forelimb

Weishaupt, Nina; Vavrek, Romana; Fouad, Karim

doi:10.1016/j.neulet.2013.01.043

Cited by 13 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we observed that 6 weeks of aerobic exercise training increased vascularization in the intact diaphragm of SCI TR group compared to SCI SED group. Cervical SCI commonly affects ipsilateral forelimb and rehabilitative training is usually provided for the recovery of locomotor skills 32,33 . Usually, BBB score is widely used to test behavioral consequences of training efficacy in animal models of spinal cord injury 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury

Jesus

Michel‐Flutot

Deramaudt

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Cervical spinal cord injury (SCI) results in permanent life-altering motor and respiratory deficits. Other than mechanical ventilation for respiratory insufficiency secondary to cervical SCI, effective treatments are lacking and the development of animal models to explore new therapeutic strategies are needed. The aim of this work was to demonstrate the feasibility of using a mouse model of partial cervical spinal hemisection at the second cervical metameric segment (C2) to investigate the impact of 6 weeks training on forced exercise wheel system on locomotor/respiratory plasticity muscles. To measure run capacity locomotor and respiratory functions, incremental exercise tests and diaphragmatic electromyography were done. In addition, muscle fiber type composition and capillary distribution were assessed at 51 days following chronic C2 injury in diaphragm, extensor digitorum communis (EDC), tibialis anterior (TA) and soleus (SOL) muscles. Six-week exercise training increased the running capacity of trained SCI mice. Fiber type composition in EDC, TA and SOL muscles was not modified by our protocol of exercise. The vascularization was increased in all muscle limbs in SCI trained group. No increase in diaphragmatic electromyography amplitude of the diaphragm muscle on the side of SCI was observed, while the contraction duration was significantly decreased in sedentary group compared to trained group. Cross-sectional area of type IIa myofiber in the contralateral diaphragm side of SCI was smaller in trained group. Fiber type distribution between contralateral and ipsilateral diaphragm in SCI sedentary group was affected, while no difference was observed in trained group. In addition, the vascularization of the diaphragm side contralateral to SCI was increased in trained group. All these results suggest an increase in fatigue resistance and a contribution to the running capacity in SCI trained group. Our exercise protocol could be a promising non-invasive strategy to sustain locomotor and respiratory muscle plasticity following SCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury

Jesus

Michel‐Flutot

Deramaudt

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…From the laboratory of Karim Fouad, rats performed worse on the horizontal ladder when they were trained only for a pellet-reaching task 32 and there was a negative impact on motor performance of the contralateral forelimb when the SCIaffected forelimb received both specific and general training. 33 The authors proposed the possibility of competition for spared circuitry between the forelimbs and the tasks being trained for. In a study designed to take advantage of a combination of exercise and chondroitinase-induced plasticity, Garcia-Alias and colleagues 34 demonstrated enhanced manual dexterity when rats received taskspecific training, but this reaching skill was diminished in rats that received only general locomotor training (ladder walking).…”

Section: Cautionary Tales Of Exercise-related Aberrant Recoverymentioning

confidence: 99%

Exercise and Peripheral Nerve Grafts as a Strategy To Promote Regeneration after Acute or Chronic Spinal Cord Injury

Theisen

Sachdeva

Austin

et al. 2017

Journal of Neurotrauma

View full text Add to dashboard Cite

Therapeutic interventions after spinal cord injury (SCI) routinely are designed to address multiple aspects of the primary and/or secondary damage that occurs. Exercise has a demonstrated efficacy for post-SCI complications such as cardiovascular dysfunction, neuropathic pain, and chronic inflammation, yet there is little understanding of the mechanisms by which improvements might result from this non-invasive approach. Here we review several of our observations of molecular and cellular changes within the injured spinal cord following acute or delayed exercise regimens that illustrate the potential for positive effects on neuroprotection and rehabilitation. Further, we provide new information about the role of exercise in promoting the regeneration of spinal axons into peripheral nerve grafts (PNGs) placed immediately or 6 weeks after injury. Acute and chronically injured propriospinal neurons within the lumbar spinal cord displayed the greatest propensity for enhanced regeneration after exercise, which correlates with the direct sensory input to this region from exercised hindlimb muscles. Future studies will extend these observations by testing whether exercise will boost the regenerative effort of axons to extend beyond the graft, interact with intraspinal targets, and establish functional connections across a lesion.

show abstract

“…However, active exercise and rehabilitation regimens have demonstrated some success at restoring locomotor ability in incomplete SCI, and that altered neural plasticity may contribute to recovery (Jung et al, 2014;Martinez et al, 2013;Shin et al, 2014;Yang et al, 2014). Previous studies have applied targeted exercise or rehabilitation regimens spanning 5-6 weeks upon initiation of SCI (Shah et al, 2012(Shah et al, , 2013Weishaupt et al, 2013) though some locomotorbased training models have extended to 12 weeks in length (Multon et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Treadmill training induced lumbar motoneuron dendritic plasticity and behavior recovery in adult rats after a thoracic contusive spinal cord injury

Wang¹,

Liu

Zhang

et al. 2015

Experimental Neurology

View full text Add to dashboard Cite

Training following unilateral cervical spinal cord injury in rats affects the contralesional forelimb

Cited by 13 publications

References 13 publications

Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury

Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury

Exercise and Peripheral Nerve Grafts as a Strategy To Promote Regeneration after Acute or Chronic Spinal Cord Injury

Treadmill training induced lumbar motoneuron dendritic plasticity and behavior recovery in adult rats after a thoracic contusive spinal cord injury

Contact Info

Product

Resources

About