2008
DOI: 10.1128/jvi.01694-06
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TRAIL Is a Novel Antiviral Protein against Dengue Virus

Abstract: Dengue fever is an important tropical illness for which there is currently no virus-specific treatment. To shed light on mechanisms involved in the cellular response to dengue virus (DV), we assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of infected primary human cells and identified changes common to all cells. The common response genes included a set of 23 genes significantly induced upon DV infection of human umbilical vein endothelial cells (HUVECs), dendritic cells (DCs), monocyt… Show more

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Cited by 61 publications
(73 citation statements)
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References 45 publications
(47 reference statements)
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“…We initiated this study because primary human cell culture experiments showed that TRAIL was induced after DENV infection and that treatment of human myeloid cells with exogenous, recombinant TRAIL inhibited DENV infection through an apoptosis-independent mechanism (40). To address the physiological function of TRAIL in vivo in the context of infection by a flavivirus, we assessed WNV pathogenesis in wild-type and TRAIL Ϫ/Ϫ mice.…”
Section: Discussionmentioning
confidence: 99%
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“…We initiated this study because primary human cell culture experiments showed that TRAIL was induced after DENV infection and that treatment of human myeloid cells with exogenous, recombinant TRAIL inhibited DENV infection through an apoptosis-independent mechanism (40). To address the physiological function of TRAIL in vivo in the context of infection by a flavivirus, we assessed WNV pathogenesis in wild-type and TRAIL Ϫ/Ϫ mice.…”
Section: Discussionmentioning
confidence: 99%
“…Previous in vitro studies suggested that addition of high doses (e.g., 5 to 20 g/ml) of exogenous recombinant human TRAIL to cell cultures could inhibit infection with DENV, a related flavivirus (40). To assess directly the role of TRAIL in the context of WNV infection in vivo, we compared the survival rates of 8-to 9-week-old wild-type and congenic TRAIL Ϫ/Ϫ mice after subcutaneous infection with 10 2 PFU of a North American WNV isolate (New York, 2000).…”
Section: Trail Is Required To Protect Mice From Lethal Wnv Infectionmentioning
confidence: 99%
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“…Yadav, et al, (22) en 1991, reportaron asociación entre los niveles de TNFα y el choque por dengue. Otro mediador de interés es el TRAIL, que regula la replicación de monocitos infectados con el virus del dengue, lo cual evidencia así su actividad antiviral (23). La liberación de TRAIL como respuesta a la infección por el el virus del dengue, hace parte importante de la respuesta inflamatoria que esta induce.…”
unclassified
“…A dengue grave em crianças causa um risco maior de choque enquanto que em adultos há um risco maior de hemorragias e danos aórgãos (SCREATON et al, 2015). (DEVIGNOT et al, 2010), (GOMES et al, 2010), (HOANG et al, 2010), (KWISSA et al, 2014a), (LOKE et al, 2010), (LONG et al, 2009), (SIMMONS et al, 2007, (UBOL et al, 2008), (WARKE et al, 2008), (NASCIMENTO et al, 2009), (SUN et al, 2013 NAKAYA et al, 2007).…”
Section: Manifestações Clínicasunclassified