TRAIL in the mandarin fish Siniperca chuatsi: Gene and its apoptotic effect in HeLa cells

Gao, Yuan; Chang, Ming Xian; Sun, Bo; Nie, Pin

doi:10.1016/j.fsi.2007.08.001

Cited by 16 publications

(6 citation statements)

References 34 publications

(38 reference statements)

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“…TNF-related apoptosis-inducing ligand sequences have been characterized in several teleost fish, such as grass carp ( 157 ), zebrafish ( 152 ), rainbow trout ( 41 ), pufferfish ( 41 ), and mandarin fish ( 158 ) (summarized in Table 3 ). In humans, there is only a single TRAIL gene while two genes have been reported in avian species ( 41 ).…”

Section: Tnf-related Apoptosis-inducing Ligandmentioning

confidence: 99%

“…In zebrafish, overexpression of TRAIL has been reported to induce cell death by activation of the extrinsic apoptosis pathway machinery ( 152 ). In parallel, mandarin fish recombinant TRAIL-induced apoptosis of HeLa cells ( 158 ) although it was previously reported that the extracellular domain of the death receptors (DR) for TRAIL in zebrafish differs from those in human DR4 and DR5 ( 152 ), suggesting that cross-reactivity with mammalian DRs could only be achieved with certain fish TRAIL proteins. In mammals, TRAIL is involved in B cell differentiation at the GC reaction, and although fish lack secondary lymphoid structures and do not form GCs, it would be of great interest to investigate what is the role of TRAIL on B cells from lower vertebrates.…”

Section: Tnf-related Apoptosis-inducing Ligandmentioning

confidence: 99%

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Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Tafalla¹,

Granja²

2018

Front. Immunol.

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Most ligands and receptors from the tumor necrosis factor (TNF) superfamily play very important roles in the immune system. In particular, many of these molecules are essential in the regulation of B cell biology and B cell-mediated immune responses. Hence, in mammals, it is known that many TNF family members play a key role on B cell development, maturation, homeostasis, activation, and differentiation, also influencing the ability of B cells to present antigens or act as regulators of immune responses. Evolutionarily, jawed fish (including cartilaginous and bony fish) constitute the first animal group in which an adaptive immune response based on B cells and immunoglobulins is present. However, until recently, not much was known about the expression of TNF ligands and receptors in these species. The sequences of many members of the TNF superfamily have been recently identified in different species of jawed fish, thus allowing posterior analysis on the role that these ligands and receptors have on B cell functionality. In this review, we summarize the current knowledge on the impact that the TNF family members have in different aspects of B cell functionality in fish, also providing an in depth comparison with functional aspects of TNF members in mammals, that will permit a further understanding of how B cell functionality is regulated in these distant animal groups.

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Section: Tnf-related Apoptosis-inducing Ligandmentioning

confidence: 99%

Section: Tnf-related Apoptosis-inducing Ligandmentioning

confidence: 99%

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Tafalla¹,

Granja²

2018

Front. Immunol.

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“…However, outbreaks of diseases caused by parasites, bacteria and viruses have greatly threatened the aquaculture industry [33]. Research has been conducted to understand the immune system in mandarin fish [34][35][36][37][38]. In this study, we report cDNA cloning, characterization, and tissue distribution of the JAK/STAT family members from the mandarin fish.…”

Section: Introductionmentioning

confidence: 99%

The JAK and STAT family members of the mandarin fish Siniperca chuatsi: Molecular cloning, tissues distribution and immunobiological activity

Guo

Zhang

Yang

et al. 2009

Fish & Shellfish Immunology

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“…The TNFSF10 gene in grass carp ( Ctenopharyngodon idella ) and three Japanese pufferfish ( Takifugu rubripes ) TNFSF10 homologous genes have been identified (Biswas et al., 2015; Chang et al., 2006). The cross‐species apoptosis‐inducing ability of mandarin fish ( Siniperca chuatsi ) and Japanese pufferfish TNFSF10 has been proven (Gao et al., 2008; Li et al., 2011). However, to our knowledge, few studies have characterized its immunologic roles in pathogen infection.…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, expressional analyses and functional identification of TRAIL in tilapia, Oreochromis niloticus

Sun

et al. 2022

Journal of Fish Diseases

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The tumour necrosis factor superfamily (TNFSF) plays critical roles in tumour apoptosis, tissue morphogenesis and lineage determination. TNFSF10 (TRAIL or Apol-2) belongs to the tumour necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumour cell lines upon binding to death-inducing signalling receptors. In this study, we identified TNFSF10 from Nile tilapia (Oreochromis niloticus) and found it was most closely related to Japanese pufferfish (Takifugu rubripes) TNFSF10. Amino acid identity between tilapia TNFSF10 and mandarin fish (Siniperca chuatsi) TRAIL was 69.2%. The highest expression of TNFSF10 mRNA was observed in the liver. In vitro studies showed that the mRNA expression of TNFSF10 was significantly stimulated by LPS in head kidney leucocytes, but remarkably inhibited by Poly I:C in spleen leucocytes. In vivo studies showed Streptococcus agalactiae infection significantly induced the mRNA expression of TNFSF10 in both the head kidney and spleen. The soluble recombinant protein Trx-TNFSF10 could induce cytotoxicity and apoptosis in HeLa cells with cycloheximide as a promoter. Taken together, these results in this study indicate that TNFSF10 may play important roles in the immune system of Nile tilapia.

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TRAIL in the mandarin fish Siniperca chuatsi: Gene and its apoptotic effect in HeLa cells

Cited by 16 publications

References 34 publications

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

The JAK and STAT family members of the mandarin fish Siniperca chuatsi: Molecular cloning, tissues distribution and immunobiological activity

Molecular cloning, expressional analyses and functional identification of TRAIL in tilapia, Oreochromis niloticus

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