Traffic of L‐selectin‐negative T cells to sites of inflammation

Rigby, Shawn; Dailey, Morris O.

doi:10.1002/1521-4141(200001)30:1<98::aid-immu98>3.0.co;2-#

Cited by 32 publications

(18 citation statements)

References 21 publications

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“…It was suggested that these activated lymphocytes of the middle ear effusion could be implicated to play a role in the inflammatory reaction in the middle ear. This agrees with other data, which demonstrate preferential trafficking of T cells lacking l ‐selectin into sites of inflammation [ 14 ]. Our results may therefore indicate that the L‐selectin – T cells of the adenoid are selectively migrating out into the adenoid secretion.…”

Section: Discussionsupporting

confidence: 93%

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Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

2002

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Ivarsson M, Lundin BS, Lundberg C. Activated T Cells in the Surface Secretion on the Adenoid ± a Flow Cytometric Study. Scand J Immunol 2002;56:310±314 We previously demonstrated the presence of leucocytes in the adenoid surface secretion with the ability of immunoglobulin A (IgA), IgM and IgG production as well as production of cells with phagocytic capacity. In the present study, we investigated the presence of activated T cells in the secretion.Adenoid surface secretion from 12 children subjected to adenoidectomy was obtained with an imprint method. From six children, peripheral blood was also obtained. By flow cytometry, the number of lymphocytes, granulocytes, epithelial cells and red blood cells was analysed as well as the expression on lymphocyte subsets of the following antigens: CD3, CD4, CD8, CD19, CD25, CD38, CD45RO, CD45RA, HLA-DR, TcRgd, CD161 and L-selectin.The majority of T cells were activated and to a significantly higher degree were CD45RO, CD161and L-selectin À , as compared with the corresponding peripheral blood. The median percentage of B cells and T cells in the secretion were 81 and 13%, respectively.In conclusion, the proportion of B and T cells in the adenoid surface secretion is significantly different as compared with the peripheral blood. The T cells in the adenoid surface secretion are to a high degree activated. The results suggest that the leucocytes in the surface secretion are part of the mucosal defence.

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Section: Discussionsupporting

confidence: 93%

“…trafficking of T cells lacking L-selectin into sites of inflammation [14]. Our results may therefore indicate that the L-selectin ± T cells of the adenoid are selectively migrating out into the adenoid secretion.…”

Section: Discussionmentioning

confidence: 63%

Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

2002

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“…We present in vivo MRI methods for cell tracking. In our approach, cells of interest are labeled ex vivo with a "tracer" perfluoropolyether (PFPE) nanoemulsion, introduced into a subject, and cell migration is monitored using spin density-weighted 19 F MRI (5). The key advantage of this platform is that the 19 F images are specific for the labeled cells with no interference from the host's tissues.…”

mentioning

confidence: 99%

“…The detection of PFPE-labeled cells using 19 F MRI or magnetic resonance spectroscopy is fundamentally different from prior methods for labeling and detecting cells with paramagnetic agents, such as with superparamagnetic iron oxide and related reagents (6 -9). Cells labeled with metal ion-based contrast agents are detected indirectly via the agent's effect on the T 1 , T 2 , and/or T* 2 of surrounding 1 H in mobile water.…”

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confidence: 99%

In vivo cytometry of antigen‐specific t cells using ¹⁹F MRI

Srinivas

Turner

Janjić

et al. 2009

Magnetic Resonance in Med

144

208

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“…This raises the possibility that Sag-induced homing of lymphocytes to peripheral LN does not require Lselectin. It has recently been suggested that L-selectinnegative T cells participate in inflammatory responses [39].…”

Section: Discussionmentioning

confidence: 99%

Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

et al. 2002

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Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking g 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wildtype mice were g 7 and g 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than g 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.

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Traffic of L‐selectin‐negative T cells to sites of inflammation

Cited by 32 publications

References 21 publications

Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

In vivo cytometry of antigen‐specific t cells using ¹⁹F MRI

Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

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Traffic of L‐selectin‐negative T cells to sites of inflammation

Cited by 32 publications

References 21 publications

Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

Activated T Cells in the Surface Secretion on the Adenoid – a Flow Cytometric Study

In vivo cytometry of antigen‐specific t cells using 19F MRI

Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

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Product

Resources

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In vivo cytometry of antigen‐specific t cells using ¹⁹F MRI