Traditional uses, phytochemistry, and pharmacological properties of <i>Sophora alopecuroides L</i>

Huang, Yanxia; Wang, Ge; Zhu, Jingde; Zhang, Rui

doi:10.1177/1721727x16642779

Cited by 22 publications

(10 citation statements)

References 19 publications

(21 reference statements)

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“…S. alopecuroides L. has a great effect as an anti-inflammatory. The main effective substances associated with anti-inflammatory activity are considered the alkaloids of S. alopecuroides L. ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats

Erdenechimeg

Guiqide

Dejidmaa³

et al. 2017

Braz J Med Biol Res

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Lider-7-tang, a medicine used for the treatment of respiratory diseases especially pneumonia and fever in Mongolian Traditional Medicine, was selected for this phytochemical and pharmacological study. The objectives of the study were to determine total biological active substances and analyze the effects of Lider-7-tang treatment in rats with acute lung injury (ALI). Quantitative determination of the total active constituents (phenolic, flavonoid, iridoid and alkaloid) of the methanol extract of Lider-7-tang was performed using Folin-Ciocalteu reagent, aluminum chloride reagent, Trim-Hill reagent, and Bromocresol green reagent, respectively. A total of fifty 8–10-week-old male Wistar rats (200–240 g) were randomized into three groups: control group, lipopolysaccharide (LPS) group (7.5 mg/kg) and LPS+Lider-7 group (90 mg/kg Lider-7-tang before LPS administration). The total content of alkaloids was 0.2±0.043%, total phenols 7.8±0.67%, flavonoids 3.12±0.206%, and iridoids 0.308±0.0095%. This study also evaluated the effects of Lider-7 on levels of inflammatory mediators by observing histopathological features associated with LPS-induced ALI. The rats pretreated with Lider-7 had significantly lower levels of IL-6 (at 3 and 6 h), and TNF-α (at 3, 6, 9, and 12 h). The current study showed that Lider-7 exerted a preventive effect against LPS-induced ALI, which appeared to be mediated by inhibiting the release of pro-inflammatory cytokines.

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Section: Introductionmentioning

confidence: 99%

Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats

Erdenechimeg

Guiqide

Dejidmaa³

et al. 2017

Braz J Med Biol Res

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“…As for its anti-cancer roles, ALO induces anti-tumor effects against several human cancers, including multiple myeloma, prostate cancer, breast cancer, thyroid cancer, osteosarcoma, and hepatocellular carcinoma. 34 In addition, ALO can significantly induce apoptosis in colon cancer (SW480 and HCT116) cells. 35 Although ALO induces cell cycle stagnation in the G2/M phase and simultaneously induces p21 and p53 expression to increase and decrease the expression of Cyclin D1 and B1, its specific target remains unclear.…”

Section: Dovepressmentioning

confidence: 99%

<p>Aloperine Exerts Antitumor Effects on Bladder Cancer in vitro</p>

Zhang¹,

Liang²,

Liu³

et al. 2020

OTT

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Background: Human bladder cancer is the most common malignant tumor of the urinary system and one of the 10 most common tumors of the whole body. Although most patients with bladder cancer exhibit a good prognosis with standard treatment, effective therapies for patients with a recurrent or advanced bladder cancer are unavailable. Therefore, highly effective drugs to treat such patients need to be developed. Aloperine (ALO), a natural compound isolated from Sophora alopecuroides, has antitumor properties. However, the role of ALO in human bladder cancer remains unclear. Methods: In the present study, MTT was used to detect the cytotoxic effect of ALO on human BC cell line EJ and human urothelium cell line SV-HUC-1cells. Meanwhile, in order to investigate the effects of ALO on the proliferation, apoptosis, migration, and invasion of BC EJ cells and its mechanism by Cell Counting Kit-8 (CCK-8) assay, immunofluorescence, Hoechst 33342 staining, wound scratch assay, transwell migration and invasion assay, Western blot analysis. Results: ALO can inhibit the proliferation and invasion of human bladder cancer EJ cells, and is low-toxic to human urothelium cells. Moreover, it can promote cellular apoptosis in vitro. Further analysis demonstrated the involvement of Caspase-dependent apoptosis following ALO treatment. ALO also downregulated the protein expression levels of Ras, p-Raf1 and p-Erk1/2. Conclusion: ALO is a potential drug for human bladder cancer therapy.

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“…These alkaloids can be classified into four types, namely, matrine‐type, cytisine‐type, aloperine‐type and sparteine‐type alkaloids [1,2,4–8] . In particular, matrine‐type alkaloids exhibit a wide range of activities, including anti‐inflammatory, [2,4,5,8–11] antiviral, [1,4–6,8] antitumor, [4,5,8,12–14] antibacterial, [8] antifibrosis, [5] anti‐arrhythmia [15] and immunosuppressive [5] . In China, some matrine‐type alkaloids, such as matrine and oxymatrine, have been used for the treatment of inflammation, hepatitis B and cancer in the clinic [4,6,9–11,16] .…”

Section: Introductionmentioning

confidence: 99%

Matrine‐Type Alkaloids from the Seeds of Sophora alopecuroides and Their Potential Anti‐inflammatory Activities

Dai

Xiaoqiong

et al. 2021

Chemistry & Biodiversity

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Three new matrine‐type alkaloids, 8β‐hydroxyoxysophoridine (1), 9β‐hydroxysophoridine (2), 9β‐hydroxyisosophocarpine (3), together with one known analog, 11,12‐dehydromatrine (4), were isolated from the seeds of Sophora alopecuroides L. The structures of new compounds were elucidated using extensive spectroscopic techniques including the experimental and calculated ECD data. The anti‐inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide were evaluated. Among them, 8β‐hydroxyoxysophoridine (1) showed a significant inhibitory effect with an IC50 value of 18.26 μM.

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Traditional uses, phytochemistry, and pharmacological properties of Sophora alopecuroides L

Cited by 22 publications

References 19 publications

Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats

Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats

<p>Aloperine Exerts Antitumor Effects on Bladder Cancer in vitro</p>

Matrine‐Type Alkaloids from the Seeds of Sophora alopecuroides and Their Potential Anti‐inflammatory Activities

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