Traditional uses, phytochemistry and pharmacological activities of the genus Cinnamomum (Lauraceae): A review

Wang, Jun; Su, Ben-Zheng; Jiang, Haiqiang; Cui, Ning; Zong-yuan, YU; Yang, Yuhan; Sun, Yu

doi:10.1016/j.fitote.2020.104675

Cited by 78 publications

(49 citation statements)

References 77 publications

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“…Trans-cinnamaldehyde (tCA) is one of the major phytochemical constituents isolated from the stem bark of Cinnamomum cassia (L.) J. Presl (Cinnamon), which is frequently used in traditional medicine for the prevention and treatment of various diseases such as ischemia, anxiety, arrhythmia, indigestion, diabetes, gastritis, blood circulation disorders, and so on [18][19][20]. A number of previous studies have shown that tCA has a variety of beneficial pharmacological effects, including anti-inflammatory, antioxidant, anti-diabetic, anti-obesity, neuroprotective, and anti-tumor effects in a number of in vitro and in vivo models [21][22][23][24][25][26][27].…”

Section: Ivyspringmentioning

confidence: 99%

Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts

et al. 2021

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Section: Ivyspringmentioning

confidence: 99%

Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts

et al. 2021

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“…Both the positive and negative ion modes were used to acquire the MS spectra of each compound. In total, 21 compounds, namely protocatechuic acid, protocatechualdehyde, syringaldehyde, cinnamaldehyde, and coumarin from C. cassia [ 16 ]; albiflorin, paeoniflorin, benzoylpaeoniflorin, 1,2,3,4,6-O-pentagalloylglucose, and catechin from P. lactiflora [ 17 ]; schaftoside, liquiritin apioside, liquiritin, liquiritigenin, isoliquiritin, isoliquiritigenin, glycyrrhizin, and glycyrrhetinic acid from G. uralensis [ 17 ]; 6-gingerol and 6-shogaol from Z. officinale [ 18 ]; and isovitexin from Z. jujuba [ 19 ], were identified. The detailed MS data are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Gyeji-Tang on MMP-9 Activity and the Expression of Adhesion Molecules in IL-4- and TNF-α-Stimulated BEAS-2B Cells

Kim

Jeon

Hwang

et al. 2021

Plants

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Gyeji-tang (GJT), a traditional herbal formula composed of five herbal medicines, is commonly used to treat the common cold, exogenous febrile disease, fever and headaches in Korea, China and Japan. Although various pharmacological activities of GJT have been reported in several studies, the effect of GJT water extract (GJTWE) on airway inflammation has not yet been investigated. This study aimed to evaluate the effects of GJTWE on airway inflammation-related factors using human bronchial epithelial BEAS-2B cells, and to identify the phytochemicals in GJTWE by ultra-performance liquid chromatography-diode array detector-tandem mass spectrometry (UPLC-DAD-MS/MS) analysis. GJTWE significantly decreased the production of chemokines, including eotaxin-3, eotaxin-1, regulated on activation normal T-cell expressed and secreted (RANTES), and matrix metalloproteinase-9, and the expression of the adhesion molecules, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, in interleukin-4 + tumor necrosis factor-α (IT)-stimulated BEAS-2B cells. In the UPLC-DAD-MS/MS analysis, 21 phytochemicals, including six flavonoids, two chalcones, five terpenoids, six phenolics, one phenylpropanoid and one coumarin, were identified in GJTWE. The findings suggested that GJTWE might exhibit anti-inflammatory effects on airway inflammation by regulating the expression of inflammatory response-related factors in IT-stimulated BEAS-2B cells; further studies are required to determine the bioactive compounds involved in the inhibition of airway inflammation.

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“…Various traditional uses of Cinnamomum plants motivated a series of experimental investigations of the plant’s pharmacological properties ( Wang et al, 2020 ). Those experimental approaches tempted to validate the potential uses of these plants as therapeutic remedies.…”

Section: Preclinical Studies Related To Pharmacological Activities and Potential Mechanisms Of Cinnamomum’ S Phyto-conmentioning

confidence: 99%

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

Sharifi‐Rad

Dey

Koirala³

et al. 2021

Front. Pharmacol.

103

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The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.

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Traditional uses, phytochemistry and pharmacological activities of the genus Cinnamomum (Lauraceae): A review

Cited by 78 publications

References 77 publications

Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts

Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts

Inhibitory Effects of Gyeji-Tang on MMP-9 Activity and the Expression of Adhesion Molecules in IL-4- and TNF-α-Stimulated BEAS-2B Cells

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

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