Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: A review

Sarkhail, Parisa

doi:10.1016/j.jep.2014.08.034

Cited by 96 publications

(91 citation statements)

References 148 publications

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“…The genus Peucedanum (Apiaceae), comprising more than 120 species, grows across Asia, Africa, and Europe (Sarkhail, 2014). Several Peucedanum species have been traditionally used for the therapeutic treatments of various conditions (reviewed in Sarkhail (2014)).…”

Section: Introductionmentioning

confidence: 99%

“…Several Peucedanum species have been traditionally used for the therapeutic treatments of various conditions (reviewed in Sarkhail (2014)). Numerous phytochemical studies have been conducted on Peucedanum plants and several bioactive substances, such as coumarins and essential oils, have been isolated (Ciesla, SkalickaWozniak, Hajnos, Hawryl, & Waksmundzka-Hajnos, 2009;Schinkovitz, Gibbons, Stavri, Cocksedge, & Bucar, 2003;SkalickaWozniak, Los, Glowniak, & Malm, 2009).…”

Section: Introductionmentioning

confidence: 99%

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In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb

Taira

Nugara

Inafuku

et al. 2017

Journal of Functional Foods

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb

Taira

Nugara

Inafuku

et al. 2017

Journal of Functional Foods

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“…The major constituents of most Peucedanum plants are coumarins and essential oils like most plants of the Umbelliferae family and they are important for their pharmacological activities of Peucedanum species (Sarkhail 2014). Among the Peucedanum species, the most frequently studied species are P. praeruptorum, P.…”

Section: List Of Schemesmentioning

confidence: 99%

“…According to their relative configurations, cis-khellactones are generally divided into the (3'R,4'R)-and (3'S,4'S)-khellactone esters. In addition, enantiomers and diastereomers could occur (Sarkhail 2014). Angular dihydropyranocoumarins were isolated mainly from the genera Peucedanum, Angelica, and Seseli, which belong to the Umbelliferae family (Lee et al 2015;Chun et al 2016;Jung et al 2012).…”

Section: Peucedanum Japonicum Thunberg Is Widely Distributed In Southmentioning

confidence: 99%

Angular dihydropyranocoumarins from Peucedanum japonicum roots

Min¹,

Kim²

2014

Planta Med

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Peucedanum japonicum Thunberg, belongs to Umbelliferae family, was distributed in southern and eastern Asian countries. Its roots were traditionally used as a medicine for cold and neuralgic diseases in Korea and Taiwan.It was reported that the roots of this plant contained coumarins, chromones, polyacetylenes, sugar alcohols, and steroid glycosides. Pharmacological researches revealed that P. japonicum roots showed antioxidative, anti-inflammatory, antifungal activity and cytotoxic effect against lymphocytic leukaemia. Isolated angular dihydropyranocoumarins (khellactones) included monoacyland diacyl-type khellactone esters. In the case of monoacylkhellactones, the absolute configuration was easily determined by the Mosher method. However, the absolute configuration of diacyl khellactone esters was difficult to assign due to the absence of free hydroxyl group. Therefore, partial alkaline hydrolysis prior to MTPA derivatization and X-ray diffraction analysis were applied to determine the absolute configurations at 3'-and 4'-positions. Because the success of partial hydrolysis and single crystallization was very difficult, ECD spectroscopy was suggested to confirm the absolute configuration of most of the compounds.Interestingly, a few enantiomers were discovered and isolated by enantioselective column. Enantiomers were usually detected and isolated using chiral column. However, RP-HPLC analysis with MTPA reaction products could be alternative method to confirm enantiomer existence without testing a number of chiral-selective columns. In the case of cis-monoacylkhellactones, the interconversion of substituents at 3'-and 4'-position was observed. The major MS fragment peak of khellactone esters was detected without a C-4' substituent. Thus, the position of substituents at 3' and 4' could be determined by MS fragmentation analysis without HMBC measurement.The NO production inhibitory activity of isolated compounds were tested using Griess assay in LPS-induced RAW264.7 cells . As a result, 1, 3-6, 22, 31, and 36-38 showed significant activity without cytotoxicity. The isobutyryl, senecioyl, 2-methylbutyryl, and isovaleryl moieties at 3' position played more important role than the acetyl and angeloyl groups.In conclusion, the absolute configuration of isolated compounds were assigned by various methods. Those methods will become useful guide to solve similar structures. The isolated compounds which significantly inhibited NO production were suggested as anti-inflammatory candidates from natural resources.

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“…The widespread incorporation of prenyl units resulted in the structural diversity of coumarins in both families [2]. Particularly, the genera Heracleum and Peucedanum from Apiaceae can be characterized by the dominance of furanocoumarins [3] and pyranocoumarins [4], respectively. Coumarins possessed diverse pharmacological properties, in which the cytotoxic effects were most extensively examined [5].…”

Section: Introductionmentioning

confidence: 99%

Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata

Li¹,

Jiang²,

Yang³

et al. 2016

Nat. Prod. Bioprospect.

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Four hitherto unknown prenylated coumarins, namely 6″-O-β-d-apiofuranosylapterin (1), 4′-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC50 values ranging from 15.9 to 23.2 μM.Graphical Abstract Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0107-5) contains supplementary material, which is available to authorized users.

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Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: A review

Cited by 96 publications

References 148 publications

In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb

In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb

Angular dihydropyranocoumarins from Peucedanum japonicum roots

Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata

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