Traditional uses, chemical composition and biological activities of<i>Sideritis raeseri</i>Boiss. &amp; Heldr.

Romanucci, Valeria; Fabio, Giovanni Di; D’Alonzo, Daniele; Guaragna, Annalisa; Scapagnini, Giovanni; Zarrelli, Armando

doi:10.1002/jsfa.7867

Cited by 30 publications

(28 citation statements)

References 38 publications

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“…Menoikio had significant amounts of trans-pinocarveol, trans-verbenol and myrtenol that were shown to act as potent modifiers of GABA receptor function [42]. S. raeseri samples were also poor in monoterpenes but were rich in the sesquiterpenes trans-caryophyllene and its oxide, bicyclogermacrene and a-bisabolol; that is in agreement with previous studies [3]. Previous reports on S. raeseri and S. scardica identified bicyclogermacrene and spathulenol as the main constituents of the latter [34,36].…”

Section: Discussionsupporting

confidence: 91%

“…Elemental analysis was performed on the aerial parts, as the extractability of elements depends on the nature of the element and on the infusion conditions such as temperature and steeping time [30]. Among macrominerals (P, K, Ca, Mg), potassium was the most abundant among species as expected [21,36] and calcium [3]. Sodium was the most abundant in all plants while in the case of micro-minerals, in all species the order was Fe>Mn>Zn.…”

Section: Discussionmentioning

confidence: 99%

“…Sideritis species are rich in secondary metabolites with unique bioactive properties that are classified to terpenes, sterols, coumarins, flavonoids, iridoids and lignans [1,3]. Extensive research is carried out on the identification of the metabolites and exploration of their pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies

Trikka¹,

Michailidou²,

Makris³

et al. 2019

Med Aromat Plants

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Plant species of the Sideritis genus are native to the Mediterranean region and widely used through millennia for their medicinal and culinary properties. They are mostly known as mountain tea or Shepard tea and in the last few years, they are on the spotlight due to the production of an enormous variety of bioactive secondary metabolites exerting a wide range of pharmaceutical applications. In the present study the biochemical value and the health promoting components of various indigenous Sideritis species was assessed: S. perforiata subsp. perfoliata, S. perfoliata subsp. athoa, S. syriaca, S. raeseri, S. scardica. A thorough biochemical analysis was conducted, including total phenols and flavonoid content, antioxidant activity, amino acids, elemental and polar/non polar metabolite profiling. S. perfoliata subsp. perfoliata had the most diverse and rich terpene profile among the studied species, while its infusion had the highest phenol and flavonoid content thus, showed the highest antioxidant activity. The diverse chemotype of Sideritis species can be used as a guide on the preparation of tea mixes with the desired metabolite content targeting specialized medical applications or may assist on the design of breeding strategies.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies

Trikka¹,

Michailidou²,

Makris³

et al. 2019

Med Aromat Plants

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“…Salvia, Mentha, and Sideritis are the main species belonging to Lamiaceae family. [8] The genus Sideritis, one of the most important members of the family Lamiaceae, involves more than 150 species widely distributed in Mediterranean area. This genus is represented by 46 species with >78.2% endemism rate in Turkey.…”

Section: Introductionmentioning

confidence: 99%

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Deveci

Tel‐Çayan

Duru

2018

International Journal of Food Properties

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In this study, the antioxidant, anticholinesterase, and anti-tyrosinase properties of (hexane, acetone, methanol, and water) extracts of Ferula elaeochytris and Sideritis stricta were determined with the total phenolic and flavonoid contents. The phenolic profile of the methanol and water extracts was analysed using HPLC-DAD. Protocatechuic acid was found as the major phenolic compound in the methanol (116.3 ± 3.1 µg/g) and water extracts (69.4 ± 1.3 µg/g) of F. elaeochytris. Coumarins (253.9 ± 4.1 µg/g) and catechin hydrate (175.2 ± 2.9 µg/g) were the most abundant phenolic compounds in the methanol and water extracts of S. stricta. β-carotenelinoleic acid, DPPH • , ABTS •+ , CUPRAC, and metal-chelating assays were used to evaluate antioxidant properties of the extracts. The methanol and water extracts of F. elaeochytris and the acetone and methanol extracts of S. stricta containing the highest amount of total phenolic and flavonoid contents showed the highest antioxidant activities in β-carotene-linoleic acid, DPPH • , ABTS •+ , and CUPRAC assays. The enzyme inhibitory potential of extracts was investigated against key enzymes involved in neurodegenerative (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) and skin (tyrosinase) disorders. In the cholinesterase inhibitory assays, the hexane extracts of two species exhibited the best activity against AChE, while the hexane extract of F. elaeochytris and the methanol extract of S. stricta observed to be the most active against BChE. As for anti-tyrosinase activity results of extracts, the only acetone and methanol extracts showed mild inhibitory activity for both species.

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“…Sideritis subgenera comprises four sections; Hesiodia (Moench) Bentham, Empedoclia (Rafin) Bentham, Burgsdorffia (Moench) Briquet and Siderits L . Previous phytochemical studies on this genus have revealed the presence of a wide range of secondary metabolites, including terpenes, sterols, coumarins, flavonoids (aglycones and glucosides), phenylethanoid glucosides, phenolic acids and essential oils . Due to the excellent medicinal properties and commercial values, numerous pharmacological studies have been described and have mentioned a plethora of significant biological activities, such as anti‐inflammatory, antioxidant, antitumor, hepatoprotective, neuroprotective activity and effective against Alzheimer's disease …”

Section: Introductionmentioning

confidence: 99%

NMR analysis of cultivated Sideritis euboea Heldr.

Tomou

Chatzopoulou

Skaltsa

2019

Phytochemical Analysis

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Introduction Over the last decades, the demand of medicinal plants has vastly increased. The health trend and social changes are leading to a growing demand for herbal products, as medicines and in particular as food supplements. Various cultivations of medicinal plants have been developed in order not only to respond on this enormous market, but also to offer high‐quality products. Cultivated plants have attracted great scientific interest for their rich and high standard chemical compositions. Objective Our study focuses on the phytochemical profile of cultivated Sideritis euboea Heldr., a shrub with a great commercial value. The whole isolation course of all extracts, fractions and sub‐fractions was continuously monitored and traced down using an NMR strategy, which permitted their detail characterisation and enabled us to choose the more abundant extract. Methods Aerial parts of cultivated S. euboea were extracted with solvents of increasing polarity and their secondary metabolites were identified by NMR analyses. Results So far, using various analytical methods, 16 secondary metabolites have been isolated from the methanol extract; two iridoids, seven flavones, five phenylethanoid glucosides and two phenolic acids. In addition to the previous investigation of the wild population, the present study revealed that its chemical profile is similar and even richer in phenolic compounds. Conclusion The metabolic profile of cultivated S. euboea was studied through 1H‐NMR spectra; the structures of the isolated secondary metabolites were assigned based on their one‐dimensional and two‐dimensional NMR spectra. The NMR strategy allowed us to detect even the minor compounds in the extracts.

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Traditional uses, chemical composition and biological activities ofSideritis raeseriBoiss. & Heldr.

Cited by 30 publications

References 38 publications

Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies

Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

NMR analysis of cultivated Sideritis euboea Heldr.

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