Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Kisangau, Daniel P.; Herrmann, Thora Martina; Lyaru, Herbert V.M.; Hosea, Ken M.; Joseph, Cosam C.; Mbwambo, Zakaria H.; Masimba, Pax J.

doi:10.17348/era.9.0.43-57

Cited by 28 publications

(30 citation statements)

References 6 publications

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“…In addition to this, the anti-viral efficacy of the documented plant species, either in vitro or in vivo was also verified from published literature. Therefore, this review draws heavily on the results of ethnobotanical surveys undertaken in contemporary sub-Saharan Africa on traditional medicines used to treat or manage HIV/AIDS opportunistic diseases [1][2][3][4][5][6][7][8][9][10][11][12][13], as well as secondary data collected through a review of 60 research reports, policy documents, reports from national, regional and international organizations, and conference papers published in scientific journals (53), books (4), theses (2) and one as an abstract.…”

Section: Thementioning

confidence: 99%

“…Ethnobotanical studies conducted in the following sub-Saharan African countries indicated that traditional healers and local communities extensively use medicinal plants to manage the effects of HIV/AIDS in Cameroon [2], Namibia [3,4], Rwanda [5], South Africa [6][7][8], Sudan [9], Tanzania [1,10] and Uganda [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the increasing acceptance of traditional medicines as an additional and alternative therapeutic strategy in the fight against HIV/AIDS opportunistic diseases in sub-Saharan Africa [1][2][3][4]7,8,[10][11][12][13], this rich indigenous knowledge on traditional remedies is not adequately documented. Documentation of plants used for treating and managing HIV/AIDS opportunistic diseases in sub-Saharan Africa is urgent as there is need to search for novel anti-HIV compounds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Maroyi¹

2014

Trop. J. Pharm Res

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Section: Thementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Maroyi¹

2014

Trop. J. Pharm Res

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“…The aerial parts of this plant are administered orally by traditional medicine practitioners as a decoction or an infusion to treat HIV/AIDS, oral candidiasis, herpes simplex, hepes zoster and skin rashes (Chinsembu and Hedimbi, 2010;Kisangau et al, 2011Kisangau et al, , 2007Lamorde et al, 2010). Exactly what the mechanism of action of the extract is, or why patients experience alleviation of symptoms (during or after its use) is unknown.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Kapewangolo

Hussein

Meyer

2013

Journal of Ethnopharmacology

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Ethnopharmacological relevancePlectranthus barbatus is widely used in African countries as an herbal remedy to manage HIV/AIDS and related conditions. Aim of the studyTo investigate the HIV-1 inhibitory, anti-inflammatory and antioxidant properties of P. barbatus and thereby provide empirical evidence for the apparent anecdotal success of the extracts. Materials and methodsEthanolic extract of P. barbatus's leaves was screened against two HIV-1 enzymes; protease (PR) and reverse transcriptase (RT). Cytotoxicity of the extract was determined through measuring tetrazolium dye uptake of peripheral blood mononuclear cells (PBMCs) and the TZM-bl cell line. Confirmatory assays for cytotoxicity were performed using flow cytometry and real-time cell electronic sensing (RT-CES). The free radical scavenging activity of the extract was investigated with 2,2-diphenyl-1-picrylhydrazyl while the anti-inflammatory properties of the plant extract were investigated using a Th1/Th2/Th17 cytometric bead array technique. The extract exhibited strong antioxidant activity with an IC 50 of 16 µg/ml and reduced the production of pro-inflammatory cytokines indicating anti-inflammatory potential. ConclusionThis is the first demonstration of the in vitro anti HIV-1 potential of P. barbatus including direct activity as well as through the stimulation of protective immune and inflammation responses. The low cytotoxicity of the extract is also in agreement with the vast anecdotal use of this plant in treating various ailments with no reported side-effects.

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“…The proliferation of the cells after treatment was calculated using a formula developed by Patel et al [19] and Awasare et al [23] as follows; C. abbreviata is used to treat skin rashes caused by human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) infections [15]. C. abbreviata also possess antidiabetic, antiviral, antihelminthic, antimalarial, antibacterial and antifungal and antioxidant activity [11].…”

Section: Determination Of Proliferationmentioning

confidence: 99%

In Vitro Antiproliferative Activity of Aqueous Root Bark Extract of Cassia abbreviata (Holmes) Brenan

SM¹,

RC²

2016

J Cancer Sci Ther

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Cancer is referred to as uncontrolled abnormal proliferation of body cells. Currently cancer treatment and management is a challenge due to complexity of the disease, toxicity of chemotherapy, unaffordability of treatment and severe side effects. Therefore, it is imperative to investigate complementary and alternative medicine for leads and development of anticancer drugs. Cassia abbreviate (C. abbreviata) has been traditionally used for its ethnotherapeutic properties and pharmacological activities. It has been reported to possess antiproliferative activity, though there is no scientific evidence to validate this claim. The main objective of this study was to determine the antiproliferative activity of aqueous root bark extract of C. abbreviata on hepatocellular carcinoma (HCC), vero, and macrophage cell lines in vitro. The antiproliferative activity of aqueous root bark extract of C. abbreviata was determined using MTT assay. The results showed that aqueous root bark extract of C. abbreviata has antiproliferative activity against HCC, vero and macrophage cell lines. The extract had the highest antiproliferative activity against HCC cell line with an IC 50 of 1.49 µg/ml as compared to 81.08 µg/ml and 128.38 µg/ml in macrophages and vero cells respectively. The IC 50 observed on non-cancerous normal cells (macrophages and vero cells) indicated that the plant extract had little antiproliferative effects on normal cells hence regarded as safe. The extract contained flavonoids, phenols, tannins and saponins. In conclusion the antiproliferative activity of aqueous root bark extract of Cassia abbreviata observed could be attributed to the phytochemicals present in this plant extract. The results of this study, validates the claim that aqueous root bark extract of C. abbreviata has antiproliferative activity and justifies its use in herbal medicine.

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Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Cited by 28 publications

References 6 publications

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

In Vitro Antiproliferative Activity of Aqueous Root Bark Extract of Cassia abbreviata (Holmes) Brenan

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