Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Maroyi, Alfred

doi:10.4314/tjpr.v13i9.21

Cited by 36 publications

(25 citation statements)

References 42 publications

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“…Due to the high prevalence of AIDS and drug‐resistant strains, the demand for new antiviral drugs against AIDS is rising. Various medicinal plants are used in the treatment of AIDS such as Withania somnifera (Williams‐Orlando, ), Tinospora cordifolia (Husain et al, ), Moringa oleifera (Monera‐Penduka et al, ), Hypericum perforatum (Béjaoui et al, ), Silybum marianum (Lovelace et al, ), Allium sativum (Maroyi, ), Panax ginseng (Cho & Kim, ), Lobostemon trigonus (Koffuor et al, ), Emblica officinalis (Bhagat, ), Curcuma longa (Kim et al, ), Hypoxis hemerocallidea (Jegede, Offor, Onanuga, Naidu, & Azu, ), and Sutherlandia frutescens (Wilson et al, ). Herbal medicines are used for the treatment of viral infections since ancient times.…”

Section: Hiv/aids and Medicinal Plantsmentioning

confidence: 99%

“…Its pharmacological activity is adaptogenic (Cicero et al, 2004). Glatthaar, Sacher, and Esperester (2001) Silybum marianum (Lovelace et al, 2017), Allium sativum (Maroyi, 2014), Panax ginseng (Cho & Kim, 2017), Lobostemon trigonus (Koffuor et al, 2014), Emblica officinalis (Bhagat, 2014), Curcuma longa (Kim et al, 2014), Hypoxis hemerocallidea (Jegede, Offor, Onanuga, Naidu, & Azu, 2017), and Sutherlandia frutescens (Wilson et al, 2015). Herbal medicines are used for the treatment of viral infections since ancient times.…”

Section: Medicinal Plants Used In Influenzamentioning

confidence: 99%

See 1 more Smart Citation

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

Akram

Tahir

Shah

et al. 2018

Phytotherapy Research

212

170

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Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections. It is widely accepted that medicinal plant heritage is nature gifted, precious, and fueled with the valuable resources for treatment of metabolic and infectious disorders. The aims of this review are to assemble the facts and to conclude the therapeutic potential of medicinal plants in the eradication and management of various viral diseases such as influenza, human immunodeficiency virus (HIV), herpes simplex virus (HSV), hepatitis, and coxsackievirus infections, which have been proven in diverse clinical studies. The articles, published in the English language since 1982 to 2017, were included from Web of Science, Cochrane Library, AMED, CISCOM, EMBASE, MEDLINE, Scopus, and PubMed by using relevant keywords including plants possessing antiviral activity, the antiviral effects of plants, and plants used in viral disorders. The scientific literature mainly focusing on plant extracts and herbal products with therapeutic efficacies against experimental models of influenza, HIV, HSV, hepatitis, and coxsackievirus were included in the study. Pure compounds possessing antiviral activity were excluded, and plants possessing activity against viruses other than viruses in inclusion criteria were excluded. Hundreds of plant extracts with antiviral effect were recognized. However, the data from only 36 families investigated through in vitro and in vivo studies met the inclusion criteria of this review. The inferences from scientific literature review, focusing on potential therapeutic consequences of medicinal plants on experimental models of HIV, HSV, influenza, hepatitis, and coxsackievirus have ascertained the curative antiviral potential of plants. Fifty-four medicinal plants belonging to 36 different families having antiviral potential were documented. Out of 54 plants, 27 individually belong to particular plant families. On the basis of the work of several independent research groups, the therapeutic potential of medicinal plants against listed common viral diseases in the region has been proclaimed. In this context, the herbal formulations as alternative medicine may contribute to the eradication of complicated viral infection significantly. The current review consolidates the data of the various medicinal plants, those are Sambucus nigra, Caesalpinia pulcherrima, and Hypericum connatum, holding promising specific antiviral activities scientifically proven through studies on experimental animal mo...

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Section: Hiv/aids and Medicinal Plantsmentioning

confidence: 99%

Section: Medicinal Plants Used In Influenzamentioning

confidence: 99%

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

Akram

Tahir

Shah

et al. 2018

Phytotherapy Research

212

170

View full text Add to dashboard Cite

show abstract

“…Anti-HIV activity of C. papaya [2,[65][66][67][68][69][70][71][72][73][74][75][76] Rashed et al (2013) proclaimed phytochemical screening of the polar concentrates of C. papaya Linn and the evaluation of the anti-HIV-1 advancement in J Appl Ind Sci. The methanol and watery concentrates of C. papaya were striven for their against HIV-1 activity using the syncytia advancement test.…”

Section: Papaya Health Benefits For Digestive Disordermentioning

confidence: 99%

A Review on Medical Advantages and Chemical Constituents of Carica Papaya Linn.

Priya

Srimathi

et al. 2018

Asian J Pharm Clin Res

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Papaya is an evergreen blossoming plant having rich characteristic thing; it is recognized to offer different therapeutic purposes of premium. The normal item is sound and delicious. The entire plant parts such as root, bark, peel, seeds, blooms, leaves, and squash are known to have helpful properties. It is utilized for the treatment of a various infections such as dengue fever, warts, corns, sinuses, skin inflammation, against diabetic, glandular tumors, blood pressure, digestive disorders, constipation, antibacterial, antifertility, anti-HIV, expel worms, invigorate regenerative organs and many, as needs be it can be seen as a nutraceutical. The present review focuses on salient features of nutritional composition, health benefits, medical advantages, and synthetic constituents of papaya.

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“…var. angustifolia (L.f.) J. G. Westas remedy for human immunodeficiency virus/acquired immunodeficiency syndrome which is a devastating epidemic in sub-Saharan Africa [56]. The chewed ends of the twigs of E. crispa serve as toothbrushes in South Africa [11,17,57] and Zimbabwe [58].…”

Section: Ethnomedicinal Usesmentioning

confidence: 99%

Euclea Crispa: Review of Its Botany, Ethnomedicinal Uses, and Pharmacological Properties

Maroyi

2018

Asian J Pharm Clin Res

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Euclea crispa is widely used as herbal medicine in southern Africa. This study was aimed at reviewing the botany, ethnomedicinal uses, and validated pharmacological properties of E. crispa. The literature search for information on ethnomedicinal uses and pharmacological activities of E. crispa was undertaken using databases such as web of science, BMC, science direct, elsevier, scopus, PubMed, and scielo. Other relevant literature sources included books, book chapters, websites, theses, conference papers, and other scientific publications. The extensive literature survey revealed that the bark, fruits, leaves, and roots of E. crispa are commonly used as herbal medicines for wounds, constipation, cough, stomach disorders, epilepsy, rheumatism, and diabetes. Pharmacological studies on E. crispa indicate that the species has amyloid β-peptide lowering effects, antibacterial, antidiarrheal, antifungal, and cell membrane disruption activities. E. crispa should be subjected to further scientific evaluations aimed at elucidating its chemical, pharmacological, and toxicological properties. Such detailed research should also include experimental animal studies, randomized clinical trials, and target-organ toxicity studies involving E. crispa extracts and its derivatives.

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Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Abstract: Purpose: To document the utilization of traditional medicines in managing human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) opportunistic infections in sub-

Cited by 36 publications

References 42 publications

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

A Review on Medical Advantages and Chemical Constituents of Carica Papaya Linn.

Euclea Crispa: Review of Its Botany, Ethnomedicinal Uses, and Pharmacological Properties

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