Papaya is an evergreen blossoming plant having rich characteristic thing; it is recognized to offer different therapeutic purposes of premium. The normal item is sound and delicious. The entire plant parts such as root, bark, peel, seeds, blooms, leaves, and squash are known to have helpful properties. It is utilized for the treatment of a various infections such as dengue fever, warts, corns, sinuses, skin inflammation, against diabetic, glandular tumors, blood pressure, digestive disorders, constipation, antibacterial, antifertility, anti-HIV, expel worms, invigorate regenerative organs and many, as needs be it can be seen as a nutraceutical. The present review focuses on salient features of nutritional composition, health benefits, medical advantages, and synthetic constituents of papaya.
Objective: In the present work, a series of five Mannich bases of quinazolinone nucleus synthesized by treating quinazolinones with various aromatic amines.Methods: A series of Mannich bases of quinazolinone synthesized by refluxing quinazolinone with anthranilic acid, amine, and formaldehyde in ethanol. The chemical structures of synthesized compounds were confirmed by thin-layer chromatography using the suitable solvent system and characterized by melting point and IR. The compounds screened for their antibacterial activity and antioxidant activity.Results: Antioxidant activity of the synthesized compounds was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging method. Compounds II and III showed values at 53% and 36%, respectively, when compared to that of standard ascorbic acid 24% at 10 µg/ml. Compounds II and IV showed excellent activity against Gram-negative organism Escherichia coli using ciprofloxacin as standard. Conclusion:All the synthesized compounds were screened for antimicrobial activity by cup plate by measuring inhibition zone using E. coli at a concentration range of 200-600 mcg/ml, and antioxidant activity was determined by DPPH method.
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