Traditional Chinese Medicine syndrome patterns and Qi-regulating, chest-relaxing and blood-activating therapy on cardiac syndrome X

Bi, Yang; Mao, Jingyuan; Wang, Xianliang; Ge, Yali; Wang, Heng-he; Zhang, Zhenpeng

doi:10.1016/s0254-6272(13)60124-7

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…A blood stasis animal model prepared by ligation of the coronary artery or injection of pituitrin for 7–28 days showed obvious myocardial ischemia, hypoxia, and energy remodelling, accompanied by behavioural characteristics such as retardation and decreased responsiveness, suggesting that the energy metabolism disorder caused by hypoxia may be an important mechanism for the comorbidity of cardiovascular diseases and depressive symptoms [ 32 ]. It has been demonstrated that Qi-regulating and blood circulation-promoting therapy attenuated the clinical symptoms of CHD by relieving ischemia and hypoxia [ 33 ], but less is known about whether regulating Qi and promoting blood circulation can significantly improve the health status in CHD patients with depressive symptoms by improving the energy status. Xuefu Zhuyu decoction, a prescription originating from the Qing Dynasty of China, is commonly used in the treatment of CHD patients as a traditional Chinese medicine adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

Wang

Song

Tao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Depressive symptoms have been found to be highly prevalent among patients with coronary heart disease (CHD) and seriously affect the patients’ quality of life. However, most psychotropic drugs have warnings about potential side effects. Accordingly, safer effective alternatives are urgently demanded. Angina pectoris of CHD is considered as “chest stuffiness and heartache syndrome” in traditional Chinese medicine, with the major syndrome type named Qi stagnation and blood stasis. Qi-regulating and blood circulation-promoting therapy has increasingly shown unique advantages in CHD patients. This study investigated the efficacy of Xuefu Zhuyu decoction, a representative prescription of Qi-regulating and blood circulation-promoting therapy, on angina pectoris patients with depressive symptoms. Depressive symptoms were stratified at baseline in 30 patients with stable angina pectoris who participated in both baseline and 12-week follow-up studies. After performing a stratified analysis, the angina pectoris-specific health status and traditional Chinese medicine “chest stuffiness and heartache syndrome” were evaluated by self-reports using the associated questionnaire scales, respectively. We measured serum concentrations of serotonin, brain-derived neurotrophic factor, and ATP, which are associated with the development of depression. We found that the Xuefu Zhuyu granule significantly improved the angina pectoris-specific health status in patients after 12 weeks of treatment; specifically, it had a better curative effect on patients with depressive symptoms. Xuefu Zhuyu granule also significantly improved the chest stuffiness and heartache syndrome in patients with depressive symptoms (efficacy index is 61.24%, P < 0.05 versus baseline). Interestingly, Xuefu Zhuyu granule has been found to be more susceptible to improving ATP levels in patients with depressive symptoms, indicating that the improvement in serum ATP levels might account for the better efficacy of Xuefu Zhuyu granule in patients with depressive symptoms. Our data provide prospective evidence that Xuefu Zhuyu granule improves angina pectoris-specific health status through regulating Qi and promoting blood circulation. This trial is registered with ChiCTR-IOR-15006989.

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Section: Discussionmentioning

confidence: 99%

Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

Wang

Song

Tao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, prove effectiveness of TCM via scientific trials is still a challenge. Two small non-randomized studies used the Qi-regulating, chest-relaxing, and blood-activating therapies of the TCM integrated with Western Medicine for the treatment of MVA, suggesting a potential benefit on symptoms, exercise capacity, and systemic inflammation assessed by sensitive C-reactive protein (CRP) (81).…”

Section: Transcendental Meditation and Traditional Chinese Medicinementioning

confidence: 99%

The Central Nervous System and Psychosocial Factors in Primary Microvascular Angina

Cattaneo

Halász

Cattaneo

et al. 2022

Front. Cardiovasc. Med.

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Patients diagnosed with ischemia without obstructive coronary artery disease (INOCA) comprise the group of patients with primary microvascular angina (MVA). The pathophysiology underlying ischemia and angina is multifaceted. Differences in vascular tone, collateralization, environmental and psychosocial factors, pain thresholds, and cardiac innervation seem to contribute to clinical manifestations. There is evidence suggesting potential interactions between the clinical manifestations of MVA and non-cardiac conditions such as abnormal function of the central autonomic network (CAN) in the central nervous system (CNS), pain modulation pathways, and psychological, psychiatric, and social conditions. A few unconventional non-pharmacological and pharmacological techniques targeting these psychosocial conditions and modulating the CNS pathways have been proposed to improve symptoms and quality of life. Most of these unconventional approaches have shown encouraging results. However, these results are overall characterized by low levels of evidence both in observational studies and interventional trials. Awareness of the importance of microvascular dysfunction and MVA is gradually growing in the scientific community. Nonetheless, therapeutic success remains frustratingly low in clinical practice so far. This should promote basic and clinical research in this relevant cardiovascular field investigating, both pharmacological and non-pharmacological interventions. Standardization of definitions, clear pathophysiological-directed inclusion criteria, crossover design, adequate sample size, and mid-term follow-up through multicenter randomized trials are mandatory for future study in this field.

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“…It has inherited all schools of thought and academic integrity, while constantly innovating and developing, with a long history. In recent years, the inheritance and development of traditional Chinese medicine has received unprecedented attention from the Ministry of Health, the Administration of Traditional Chinese Medicine and the local administration of traditional Chinese medicine, In 2005 and 2007, the Ministry of Science and Technology launched the National Science and Technology Research Program of the 15th and 11th Five-Year Plan -"Research on Academic Thoughts and Experience Inheritance of Famous and Old TCM", which has played a good role in promoting and promoting the summary and inheritance of the experience of famous and old TCM [8] . In 2010, the State Administration of Traditional Chinese Medicine approved for the first time the establishment of a National Heritage Studio of Famous and Old Chinese Medicine Experts by 30 Chinese Medicine Masters and 159 Chinese Medicine Experts.…”

Section: New Requirements Of the Timesmentioning

confidence: 99%

Exploration of Intelligent Development of Medical Heritage

Wang

et al. 2021

Advances in Science and Technology

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With the rapid development of science and technology, more and more new methods and technologies have been added to the traditional Chinese Medicine Inheritance model, which makes the process of inheritance of famous doctors have more means, and the results of inheritance are more objective, rigorous and intelligent. In the process of inheriting the informationization of famous doctors, there are some bottlenecks, such as data acquisition difficulties, data processing difficulties, algorithm application difficulties, analysis and summary difficulties. Integration of artificial intelligence with big data, deep learning algorithm and knowledge atlas technology has brought technological innovation to the informationization of famous doctors' inheritance. Under this wave, the team of the Intelligent Research and Development Center of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine Information, Chinese Academy of Traditional Chinese Medical Sciences, has developed a series of professional application systems in the field of traditional Chinese medicine around the planning of famous doctors' inheritance and excavation, and has developed ancient Chinese medicine, such as Today's Medical Records Cloud Platform, Medical Records Big Data Analysis Platform, Cloud Medical Records APP, Famous Medical Heritage Workstation. To a certain extent, it can solve the problems of inefficient collection of medical records, lack of objective data support and information barriers in the summary of famous doctors' experience under the limitation of traditional model, so as to promote the inheritance of famous doctors' experience and enhance the teaching ability and efficiency of teachers and apprentices.

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Traditional Chinese Medicine syndrome patterns and Qi-regulating, chest-relaxing and blood-activating therapy on cardiac syndrome X

Cited by 7 publications

References 6 publications

Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

The Central Nervous System and Psychosocial Factors in Primary Microvascular Angina

Exploration of Intelligent Development of Medical Heritage

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