Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

Wang, Xiao-Reng; Song, Dandan; Tao, Tianqi; He, Tao; Wang, Xudong; Li, Xuemei; Li, Xiuhua

doi:10.1155/2021/7319417

Cited by 9 publications

(10 citation statements)

References 36 publications

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“…To our knowledge, this is the first randomized clinical trial on the effectiveness of SA using a semipermanent needle with NSA directed at depression as the comparator group. However, previous studies [22][23][24][25][26][27][28] using other AA techniques found favorable results in depressive symptoms, but with shorter study duration and different comparators. These preliminary findings are promising and support the use of SA in depression treatment.…”

Section: Discussionmentioning

confidence: 94%

“…Of the 304 screened volunteers, 230 were excluded for various reasons, resulting in a cohort of 74 participants (62 women [84%]; median [IQR] age, 29 [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] years; 5 Black participants [7%]; 61 White participants [82%]; 8 multiracial participants [10%]) comprising the intent-to-treat sample with 37 participants randomized to SA treatment and 37 participants randomized to NSA treatment (Figure 1). At 3 months, 27 patients (36%) were lost to follow-up; a total of 47 patients (64%), including 24 patients in the SA group and 23 participants, in the NSA group, comprised the modified intent-to-treat sample.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Auricular Acupuncture for Depression

de Oliveira Rodrigues,

Menezes,

Machado Ribeiro Silotto

et al. 2023

JAMA Netw Open

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ImportanceDepression is a leading cause of disability worldwide, and there is increasing interest in nonpharmacological treatments. Auricular acupuncture (AA) is a simple, low-cost, and well-tolerated option, but further studies are needed to establish its efficacy and safety.ObjectiveTo estimate the efficacy and safety of auricular acupuncture as a treatment for depression.Design, Setting, and ParticipantsThis randomized clinical trial was conducted at 4 university research centers in Brazil, from March to July 2023. Eligible patients were adults aged 18 to 50 years whose score on the Patient Health Questionnaire–9 (PHQ-9) indicated moderate depression (score 10-14) or moderately severe depression (score 15-19). Exclusion criteria included previous application of AA, risk of suicidal ideation, or severe depression (PHQ-9 score &gt;20). An intent-to-treat analysis and modified intent-to-treat analysis were conducted.InterventionParticipants were randomized into 2 treatment groups, which included specific AA (SA) and nonspecific AA (NSA). Both groups received 12 sessions of AA with semipermanent needles with daily stimulation twice a week over 6 weeks and were followed-up for 3 months. All participants continued with their usual care for ethical reasons. The SA group’s treatment protocol consisted of 6 acupuncture points on the auricular pavilion chosen according to the diagnosis of depression by traditional Chinese medicine (Shenmen, subcortex, heart, lung, liver, and kidney). The NSA group’s acupuncture points were the external ear, the cheek and face area, and 4 nonspecific points in the helix region unassociated with mental health symptoms. A locator device was used to confirm which areas had neuroreactive points.Main Outcomes and MeasuresThe primary outcome was a reduction of at least 50% in the PHQ-9 score (ie, depression recovery) at 3 months. Secondary outcomes included depression recovery at 4 and 6 weeks; depression remission (PHQ-9 score &lt; 5) at 4 weeks, 6 weeks, and 3 months); and adverse events.ResultsA total of 304 participants were screened, and 74 participants (62 women [84%]; median [IQR] age, 29 [23-27] years) were included in the intention-to-treat analysis, with 37 participants randomized to each group (SA and NSA). A total of 47 participants (64%) were followed-up through 3 months. The results showed no statistically significant difference in depressive recovery between the groups at 3 months (14 of 24 participants in the SA group [58%] vs 10 of 23 participants in the NSA group [43%]; risk ratio [RR], 1.34; 95% CI, 0.76-2.45; P = .38). The proportions of depression recovery and remission at 4 and 6 weeks based on the PHQ-9 were higher in the SA group (except for depression recovery at 6 weeks) with no statistically significant differences. However, a statistically significant difference was observed in symptom remission at 3 months (11 of 24 participants in the SA group [46%] vs 3 of 23 participants in the NSA group [13%]; RR, 1.99; 95% CI, 1.16-3.34; P = .02) in favor of SA. There were no significant differences in adverse event rates between the groups, evidencing the intervention’s safety. Most participants reported mild pain at the needle application site (33 patients [94%] in the SA group vs 32 patients [91%] in the NSA group). Five participants dropped out of the study due to adverse events.Conclusions and RelevanceThe results of this randomized clinical trial suggest that SA over 6 weeks is safe. Although there was no statistically significant difference between groups for the primary efficacy outcome, patients receiving SA did experience greater symptom remission at 3 months. A larger sample size and longer intervention are needed to further evaluate the efficacy of SA for depression.Trial RegistrationClinicalTrials.gov Identifier: NCT05855421

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Auricular Acupuncture for Depression

de Oliveira Rodrigues,

Menezes,

Machado Ribeiro Silotto

et al. 2023

JAMA Netw Open

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“…Neuroinflammation is one of the important points for the neuronal damage and the induction of various neurological diseases. Inflammation is an essential factor in the depression pathogenesis, the pro-inflammatory cytokines could intervene in neural processes such as neural plasticity and neural survival, which leads to the induction of depression ( Wang et al, 2021b ). Patients with major depression have been repeatedly observed to have activated inflammatory pathways, as manifested by increased proinflammatory cytokines such as TNF-α and IL-1β.…”

Section: Discussionmentioning

confidence: 99%

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Li,

Dai,

et al. 2024

Front. Mol. Biosci.

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Introduction: Depression is a common illness worldwide. However, the current treatments available for depression only achieve relative success, often come with several side effects, and are associated with high costs. Aurantii Fructus Immaturus (AFI) has a rich historical legacy in Traditional Chinese Medicine (TCM) for its traditional use as a treatment for depression. In this research, our primary objective is to examine the potential antidepressant properties and the mechanisms at play behind a particular bioactive compound found in AFI, which is referred to as carbon dots derived from AFI Carbonisata (AFIC-CDs).Methods: Extracted and isolated the AFIC-CDs from the decoction of AFIC, then characterized the morphological structure and functional groups comprehensively. We then utilized two distinct models to investigate the anti-depressive properties of AFIC-CDs: the chronic unpredictable mild stress (CUMS) model and the reserpine-induced pain-depression dyad model. In the CUMS model, we assessed immobile time and measured neurotransmitter levels in the mouse brain cortex. In the pain-depression dyad model, we evaluated immobile time, neurotransmitter levels, interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) levels, and the expression of mRNA of brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 2 (Tph2).Results: AFIC-CDs were found to have abundant chemical groups, and their diameter ranged from 2 to 10 nm. In the CUMS model, AFIC-CDs demonstrated significant effects. They reduced the immobile time of the mice and increased the levels of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the mouse brain cortex. In the pain-depression dyad model, the AFIC-CDs groups decreased the immobile time, showed effect in increasing both the neurotransmitters’ levels and the expression of mRNA of BDNF and Tph2, and decreased the IL-1β and TNF-α levels in mouse brain cortex. Taken together, these results strongly indicate that AFIC-CDs possess significant antidepressant activity.Conclusion: AFIC-CDs demonstrate promising therapeutic potential in the treatment of depression, suggesting that they may become a valuable candidate for depression management. This not only extends the understanding of the biological activity of carbon dots (CDs) but also opens up new possibilities for the development of effective depression treatment strategies.

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“…TCM theory posits that the unhindered circulation of Qi and blood along the meridians is vital for life activities, and pathological conditions like “Blood stasis” and “Qi stagnation” that block the meridians can induce a range of physical and psychological ailments [ 16 ]. According to TCM theory, "Blood stasis" is the primary pathological product of MI, obstructing the heart meridian and resulting in symptoms of chest pain and tightness, “blood stasis” can also affect the normal flow of Qi in the meridians, leading to abnormal emotions such as anxiety [ 17 ]. To address this complex situation, TCM employs non-pharmacological therapies that differ from herbal treatments.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of non-pharmacological therapy under the guidance of TCM theory in the treatment of anxiety in patients with myocardial infarction: A protocol for systematic review and meta-analysis

et al. 2023

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Background With the increasing pressures of modern life and work, combined with a growing older population, the incidence of comorbid anxiety and myocardial infarction (MI) is increasing. Anxiety increases the risk of adverse cardiovascular events in patients with MI and significantly affects their quality of life. However, there is an ongoing controversy regarding the pharmacological treatment of anxiety in patients with MI. The concomitant use of commonly prescribed selective serotonin reuptake inhibitors (SSRIs) and antiplatelet medications such as aspirin and clopidogrel may increase the risk of bleeding. Conventional exercise-based rehabilitation therapies have shown limited success in alleviating anxiety symptoms. Fortunately, non-pharmacological therapies based on traditional Chinese medicine (TCM) theory, such as acupuncture, massage, and qigong, have demonstrated promising efficacy in treating MI and comorbid anxiety. These therapies have been widely used in community and tertiary hospital settings in China to provide new treatment options for patients with anxiety and MI. However, current studies on non-pharmacological TCM-based therapies have predominantly featured small sample sizes. This study aims to comprehensively analyze and explore the effectiveness and safety of these therapies in treating anxiety in patients with MI. Method We will systematically search six English and four Chinese databases by employing a pre-defined search strategy and adhering to the unique rules and regulations of each database to identify studies that fulfilled our inclusion criteria, to qualify for inclusion, patients must be diagnosed with both MI and anxiety, and they must have undergone non-pharmacological TCM therapies, such as acupuncture, massage, or qigong, whereas the control group received standard treatments. The primary outcome measure will be alterations in anxiety scores, as assessed using anxiety scales, with secondary outcomes encompassing the evaluations of cardiopulmonary function and quality of life. We will utilize RevMan 5.3 to conduct a meta-analysis of the collected data, and subgroup analyses will be executed based on distinct types of non-pharmacological TCM therapies and outcome measures Results A narrative summary and quantitative analysis of the existing evidence on the treatment of anxiety patients with MI using non-pharmacological therapies guided by Traditional Chinese Medicine theory. Conclusion This systematic review will investigate whether non-pharmacological interventions guided by TCM theory are effective and safe for anxiety in patients with MI, and provide evidence-based support for their clinical application. Systematic review registration PROSPERO CRD42022378391

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Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms

Cited by 9 publications

References 36 publications

Efficacy and Safety of Auricular Acupuncture for Depression

Efficacy and Safety of Auricular Acupuncture for Depression

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Efficacy and safety of non-pharmacological therapy under the guidance of TCM theory in the treatment of anxiety in patients with myocardial infarction: A protocol for systematic review and meta-analysis

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