Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

Abstract

Alzheimer's disease (AD) is one of the most common diseases in elderly people with a high incidence of dementia at approximately 60-80%. The pathogenesis of AD was quite complicated and currently there is no unified conclusion in the academic community, so no efficiently clinical treatment is available. In recent years, with the development of traditional Chinese medicine (TCM), researchers have proposed the idea of relying on TCM to prevent and treat AD based on the characteristic of multiple targets of TCM. This study reviewed the pathological hypothesis of AD and the potential biomarkers found in the current researches. And the potential targets of berberine and evodiamine from Evodia rutaecarpa in AD were summarized and further analyzed. A compound-targets-pathway network was carried out to clarify the mechanism of action of berberine and evodiamine for AD. Furthermore, the limitations of current researches on the TCM and AD were discussed. It is hoped that this review will provide some references for development of TCM in the prevention and treatment of AD.

Integrated comparative metabolomics and network pharmacology approach to uncover the key active ingredients of Polygonati rhizoma and their therapeutic potential for the treatment of Alzheimer’s disease

“…TCM is generally a natural product after long-term clinical practice, with good safety and low toxicity. In addition, TCM is characterized by the use of multiple compounds, multiple targets, and multiple pathways of action, thus having certain advantages for complex diseases ( Fang et al, 2020 ). Thus, we assumed that the treatment of PR might be ascribed to the integrated effects of multiple compounds, rather than a single constituent.…”

The Role of a Pathological Interaction between β-amyloid and Mitochondria in the Occurrence and Development of Alzheimer’s Disease

“…Многочисленные исследования in vivo, проведенные за последнее время, показали нейропротекторное действие алкалоида хинолина -берберина [201]. Берберин ингибирует активность ВACE1 и АХЭ, снижает уровень АФК, повышает уровень глутатиона, препятствует апоптозу и улучшает когнитивные функции [202,203]. Внесение берберина в наноструктурированные липидные носители повысило его биодоступность и эффективность в эксперименте in vivo [204].…”

Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

“…BBR can be extracted from various plant families, including Annonaceae , Berberidaceae , Menispermaceae , and Papaveraceae [ 1 ]. Over the past decades, BBR has emerged as an important compound in traditional Chinese medicine because of its wide range of applications [ 2 , 3 ]. Numerous studies have demonstrated that BBR exhibits positive pharmacological effects in many diseases such as cancer [ 4 , 5 ], inflammation [ 6 ], bacterial infection [ 7 ], reperfusion injury [ 8 ], and non-alcoholic fatty liver (NAFL) disease [ 9 ].…”