Traditional Chinese Medicine Combined With Chemotherapy and Cetuximab or Bevacizumab for Metastatic Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Abstract

Background: Huangci Granule is a traditional Chinese medicine for treating metastatic colorectal cancer (mCRC). Objective: To evaluate the efficacy and safety of Huangci Granule combination with chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC. Methods: We performed a randomized, controlled, and double-blind trial and recruited patients with mCRC who were planned to undergo chemotherapy combined with CET or BV. The treatment group was treated with Huangci Granule, while the control group was treated with placebo. Continuous treatment until disease progression, death, intolerable toxicity or up to 6 months. The primary endpoint was progression-free survival (PFS), and the secondary endpoint was quality of life and safety. Result: 320 patients were randomly assigned to receive treatment, including 200 first-line patients and 120 second-line patients. In the first-line treatment, the median PFS was 9.59 months (95% CI, 6.94-13.25) vs 6.89 months (95% CI, 4.99-9.52) in treatment group and control group (HR, 0.69; 95% CI, 0.50-0.97; P = 0.027). Chinese medicine was an independent factor affecting the PFS. In the second-line treatment, the median PFS was 6.51 months (95% CI, 4.49-9.44) vs 4.53 months (95% CI, 3.12-6.57) in the treatment group and control group (HR, 0.65; 95% CI, 0.45-0.95; P = 0.020). Compared with the control group, "role function," "social function," "fatigue," and "appetite loss" were

A network pharmacology-based investigation on the bioactive ingredients and molecular mechanisms of Gelsemium elegans Benth against colorectal cancer

“…Indeed, many chemotherapeutics derived from plants, such as paclitaxel, vinblastine, and vincristine, have proven effective against different tumors. Sometimes as a complementary therapy, medicinal plants are widely used to treat several types of cancers, including CRC, with relatively fewer and milder side effects [9,10]. As an important source of alternative and complementary medicines, traditional Chinese medicine (TCM) has been widely reported to treat cancer [11][12][13].…”

“…As an important source of alternative and complementary medicines, traditional Chinese medicine (TCM) has been widely reported to treat cancer [11][12][13]. In recent years, more and more herbs originating from TCM have attracted considerable attention as anti-CRC agents because of their therapeutic value and low toxicity [9,14].…”

Effect of PRM1201 Combined With Adjuvant Chemotherapy on Preventing Recurrence and Metastasis of Stage III Colon Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

“…Both in vitro and in vivo experiments showed that this formula can inhibit the invasion and metastasis of colon cancer (9,10). A randomized, controlled, and double-blinded clinical trial confirmed that PRM1201 combined with chemotherapy and Cetuximab or Bevacizumab can prolong the progression free survival of metastatic colorectal cancer (11). To determine whether PRM1201 can benefit patients with colon cancer in an earlier stage, we conducted this prospective interventional study in patients with stage III colon cancer.…”

Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression

“…Traditional Chinese medicines (TCM) have several advantages in the treatment of malignancies with low toxicity. 18 Therefore, TCM have received wide attention recently. 19 CCM is a well-known dietary polyphenol derived from the rhizomes of turmeric.…”

“…Therefore, there is an urgent need to develop more effective and safe drugs. Traditional Chinese medicines (TCM) have several advantages in the treatment of malignancies with low toxicity 18 . Therefore, TCM have received wide attention recently 19 .…”