<i>Curcumin</i> inhibits CT26 cells metastasis by decreasing heparanase expression

Li, Shanshan; Fu, Hui; Wang, Yiyang; Wang, Li; Jia, Beitian; Bian, Yuhong

doi:10.1002/jlb.1ma0620-357r

Cited by 6 publications

(2 citation statements)

References 33 publications

(56 reference statements)

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“…CCM inhibits colon cancer cell migration and invasion by inhibiting heparinase expression and P38 phosphorylation, which might be related to the P38-MAPK signaling pathway ( 121 , 122 ). Moreover, CCM can inhibit insulin-stimulated MAPK and MEK phosphorylation in CRC cells.…”

Section: Mitogen-activated Protein Kinase Signaling Pathwaymentioning

confidence: 99%

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

et al. 2022

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Colorectal cancer (CRC) is a common type of malignant digestive tract tumor with a high incidence rate worldwide. Currently, the clinical treatment of CRC predominantly include surgical resection, postoperative chemotherapy, and radiotherapy. However, these treatments contain severe limitations such as drug side effects, the risk of recurrence and drug resistance. Some natural compounds found in plants, fungi, marine animals, and bacteria have been shown to inhibit the occurrence and development of CRC. Although the explicit molecular mechanisms underlying the therapeutic effects of these compounds on CRC are not clear, classical signaling transduction pathways such as NF-kB and Wnt/β-catenin are extensively regulated. In this review, we have summarized the specific mechanisms regulating the inhibition and development of CRC by various types of natural compounds through nine signaling pathways, and explored the potential therapeutic values of these natural compounds in the clinical treatment of CRC.

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Section: Mitogen-activated Protein Kinase Signaling Pathwaymentioning

confidence: 99%

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

et al. 2022

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“…In colon cancer, curcumin induces FADD (Fas-Associated Protein With Death Domain), caspase-8, and caspase-3 [35] and inhibits Wnt/beta-catenin signaling, triggering apoptosis [36]. Moreover, it inhibits colon cancer metastasis by P38 MAPK-and JAK/STAT5-dependent suppression of heparanase expression [37]. Similarly, in lung cancer, curcumin modulates the circ-PRKCA/miR-384/ITGB1 pathway, suppressing the malignancy of lung carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines

Gabr

Elsaed

Eladl

et al. 2022

Life

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In cancer management, drug resistance remains a challenge that reduces the effectiveness of chemotherapy. Several studies have shown that curcumin resensitizes cancer cells to chemotherapeutic drugs to overcome resistance. In the present study, we investigate the potential therapeutic role of curcumin in regulating the proliferation of drug-resistant cancers. Six drug-sensitive (MCF7, HCT116, and A549) and -resistant (MCF7/TH, HCT116R, and A549/ADR) cancer cell lines were treated with curcumin followed by an analysis of cytotoxicity, LDH enzyme, total reactive oxygen species, antioxidant enzymes (SOD and CAT), fibrosis markers (TGF-β1 protein, fibronectin, and hydroxyproline), and expression of cellular apoptotic markers (Bcl-2, Bax, Bax/Bcl-2 ratio, Annexin V, cytochrome c, and caspase-8). Additionally, the expression of cellular SIRT1 was estimated by ELISA and RT-PCR analysis. Curcumin treatment at doses of 2.7–54.3 µM significantly reduced the growth of sensitive and resistant cells as supported with decreased viability and increased cellular LDH enzyme of treated cells compared to controls non-treated cells. Curcumin also at doses of 2.7 and 54.3 µM regulated the fibrogenesis by reducing the expression of fibrotic markers in treated cells. Analysis of apoptotic markers indicated increased Bax, Bax, Bax/Bcl-2 ratio, Annexin V, caspase-8, and cytochrome c expression, while Bcl-2 expressions were significantly reduced. In curcumin-treated cells at 2.7 μM, non-significant change in ROS with significant increase in SOD and CAT activity was observed, whereas an increase in ROS with a reduction in respective antioxidant enzymes were seen at higher concentrations along with significant upregulation of SIRT1. In conclusion, the present study shows that curcumin induces anticancer activity against resistant cancer cell lines in a concentration- and time-dependent manner. The protective activities of curcumin against the growth of cancer cells are mediated by modulating oxidative stress, regulating fibrosis, SIRT1 activation, and inducing cellular apoptosis. Therefore, curcumin could be tested as an auxiliary therapeutic agent to improve the prognosis in patients with resistant cancers.

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Recent Advancements in the Inhibition of Metastasis of Colorectal Cancer Using Anticancer Compounds

Chhetri,

Kaliappan,

Palaniyandi

et al. 2023

Handbook of Oncobiology: From Basic to Clinical Sciences

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Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression

Cited by 6 publications

References 33 publications

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways

Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines

Recent Advancements in the Inhibition of Metastasis of Colorectal Cancer Using Anticancer Compounds

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