Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1‐year prospective study

Abstract

SUMMARY BackgroundSafety of traditional Chinese medicine in patients with chronic hepatitis B is unknown.

Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

“…However, hepatic adverse effect was constantly reported since 1990s in China (Niu, 1996;Ye, 1996;Sun, 2002;Zhao, 2007) and other countries Park et al, 2001;Battinelli et al, 2004;Panis et al, 2005;Cárdenas et al, 2006;Yuen et al, 2006;Min et al, 2008;Cho et al, 2009). Rash, fever, abdominal pain, dyspnea, vision problems and palpitations were common adverse effects induced by Polygonum multiflorum.…”

Systematic review on herb-induced liver injury in Korea

“…This herb showed hepatoprotective effects in an animal model of dimethylnitrosamine-induced liver cirrhosis (Huang et al, 2007). There is however a series of reports for hepatic adverse effects associated with Polygoni Multiflori (Cárdenas et al, 2007;Yuen et al, 2006). Dictamnus dasycarpus has been used to act as a detoxifying agent, able to reduce both heat and wetness.…”

Plant Poisons and Traditional Medicines

“…They can cause the sinusoidal obstruction syndrome (veno-occlusive disease of the liver), 184 with clinical features that can occur. Plants that have been reported to cause acute liver damage include Breynia officinalis, 164 Callilepis laureola (ox-eye daisy), 165 Camellia sinensis (green tea), 166 Chelidonium majus (celandine), 167 Cimicifuga racemosa (black cohosh; Figure 76.21), 168,169 Larrea tridentata (chaparral), 170 Piper methysticum (kava; Figure 76.20; see below under Psychotropic drugs), Polygonum multiflorum, 171 Symphytum officinale (comfrey; see below under Sinusoidal obstruction syndrome) 172,173 and Teu crium spp. 174,175 Of these, black cohosh, chaparral, comfrey, and kava are the most common culprits.…”