Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

“…PM hepatotoxicity is of great concern; however, the components that induce hepatotoxicity are unknown. Besides, the present studies also have many contradictions, such as some studies demonstrated that PMW has greater toxicity than other extracts [29,30], but another study considered as PME [31]. In this assays, it is proved that the water extractions were less toxic than the 70% ethanol extractions which indicated that water decoction was a more rational extractive agent for PM and PMP.…”

Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02

“…The HPLC analysis method was consistent with our previous work (Yu et al, 2011). All experiments were performed with Dionex Ultimate 3000 HPLC system (Dionex Technologies, USA), which included a binary pump, an autosampler, a column oven and a diode array detector plus on-line degasser.…”

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

“…Hepatic adverse effects have been reported since 1900s in China and other counties, and acute toxic hepatitis was the most common reported. Rash, fever, abdominal pain, dyspnea, vision problems and palpitations were common adverse effects of Polygonum Multiflorum [15,[40][41][42][43][44][45][46] . Pharmacokinetics and pharmacology studies of TSG will provide valuable information to ensure the safety and efficacies of TSG administration.…”