Tracking whole-brain connectivity dynamics in the resting-state fMRI with post-facial paralysis synkinesis

Alzheimer's disease (AD) was associated with abnormal organization and function of large-scale brain networks. We applied group independent component analysis (Group ICA) to construct the triple-network consisting of the saliency network (SN), the central executive network (CEN), and the default mode network (DMN) in 25 AD, 60 mild cognitive impairment (MCI) and 60 cognitively normal (CN) subjects. To explore the dynamic functional network connectivity (dFNC), we investigated dynamic time-varying triple-network interactions in subjects using Group ICA analysis based on k-means clustering (GDA-k-means). The mean of brain state-specific network interaction indices (meanNII) in the three groups (AD, MCI, CN) showed significant differences by ANOVA analysis. To verify the robustness of the findings, a support vector machine (SVM) was taken meanNII, gender and age as features to classify. This method obtained accuracy values of 95, 94, and 77% when classifying AD vs. CN, AD vs. MCI, and MCI vs. CN, respectively. In our work, the findings demonstrated that the dynamic characteristics of functional interactions of the triple-networks contributed to studying the underlying pathophysiology of AD. It provided strong evidence for dysregulation of brain dynamics of AD.

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“…θ is set to a third of the window length ( 34 ). We set T to 39 s (TRs = 3 s) and sliding step to 1 s ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

A Triple-Network Dynamic Connection Study in Alzheimer's Disease

Meng

Liang

et al. 2022

Front. Psychiatry

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“…In recent years, with the rapid development of imaging technology, functional magnetic resonance imaging (fMRI) has been widely used in the treatment of intractable peripheral facial paralysis using acupuncture. fMRI can visualize the functional activities of human tissue and organs through information data, facilitate direct analysis, and is noninvasive, noncontact, and nondamage [23][24][25]. e specific action principle of fMRI is as follows: blood oxygen level dependent (BOLD) is used to observe blood flow and blood volume in some functional areas of the human brain.…”

Section: Introductionmentioning

confidence: 99%

Newly Prepared 129Xe Nanoprobe-Based Functional Magnetic Resonance Imaging to Evaluate the Efficacy of Acupuncture on Intractable Peripheral Facial Paralysis

Fan

Wang

Yao

et al. 2022

Contrast Media & Molecular Imaging

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This study focused on the application value of the newly prepared 129Xe nanoprobe-based functional magnetic resonance imaging (fMRI) in exploring the mechanism of the acupuncture treatment for intractable facial paralysis, expected to provide a theoretical reference for the mechanism of acupuncture for the treatment of facial paralysis. In this study, 30 patients with intractable peripheral facial paralysis (experimental group) and 30 healthy volunteers (control group) were selected. All patients were scanned by the newly prepared 129Xe nanoprobe-based fMRI technology, and then brain functional status data and rating data were collected. fMRI scanning results showed that multiple brain regions were activated in the experimental group before treatment, among which the central posterior brain, insula, and thalamus were positively activated, while the precuneus, superior frontal gyrus, and other parts showed signal reduction. After treatment, several brain regions also showed signal enhancement. Comparisons within the healthy control group also showed activation in multiple brain regions, including the lenticular nucleus, inferior frontal gyrus, and superior temporal gyrus, while in the experimental group, no signal changes were detected in these brain regions. At the same time, comparison of fMRI images of patients with intractable peripheral facial paralysis before and after treatment showed that the cerebellar amygdala, superior frontal gyrus, cerebellar mountaintop, and other brain areas were activated, and all showed positive activation. After treatment, the average House–Brackmann (H-B) and Sunnybrook scores of the experimental group were 3.82 and 51, respectively, and the change was significant compared with that before treatment ( P < 0.05 ). In conclusion, the newly prepared 129Xe nanoprobe-based fMRI scan can reflect the functional changes of cerebral cortex after acupuncture. The acupuncture treatment may achieve its therapeutic effect by promoting the functional reorganization of the cerebral cortex in the treatment of intractable facial paralysis.

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“…In our clinical observations, patients with homogeneous etiologies show high heterogeneity in asymmetry outcomes ( Chen et al, 2017 ; Ma et al, 2022 ). A recent study has demonstrated that facial nerve lesions induce widespread cerebral plasticity, including changes in cortical reorganization and functional connectivity, which correlate with clinical severity ( Klingner et al, 2012 ; Song et al, 2017 ; Ma et al, 2021a , b ). There is also evidence to suggest that cerebral plasticity contributes to facial muscle dysfunction ( He et al, 2014 ; Xiao et al, 2015 ; Ma et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

“…A recent study has demonstrated that facial nerve lesions induce widespread cerebral plasticity, including changes in cortical reorganization and functional connectivity, which correlate with clinical severity ( Klingner et al, 2012 ; Song et al, 2017 ; Ma et al, 2021a , b ). There is also evidence to suggest that cerebral plasticity contributes to facial muscle dysfunction ( He et al, 2014 ; Xiao et al, 2015 ; Ma et al, 2021b ). Deefferentation from the cerebral to the peripheral facial nerve leads to excessive activation of primary motor areas, resulting in enhanced facial activity ( Xiao et al, 2015 ; Ling et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…As peripheral neuropathy occurs within the top-down pathway, sensorimotor adaptation is triggered by a mismatch between the desired symmetry and excessive activation ( Klingner et al, 2014 ). Many studies have demonstrated the crucial role of sensorimotor adaptation on mismatch during facial motor tasks ( Hu et al, 2015 ; Klingner et al, 2019 ; Ma et al, 2021b ). In contrast, static facial asymmetry is the result of an imbalance of bilateral facial muscle tension.…”

Section: Introductionmentioning

confidence: 99%

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Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry

Zhou

Wang

et al. 2022

Front. Neurosci.

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Facial asymmetry is the major complaint of patients with unilateral facial nerve lesions. Frustratingly, although patients experience the same etiology, the extent of oral commissure asymmetry is highly heterogeneous. Emerging evidence indicates that cerebral plasticity has a large impact on clinical severity by promoting or impeding the progressive adaption of brain function. However, the precise link between cerebral plasticity and oral asymmetry has not yet been identified. In the present study, we performed functional magnetic resonance imaging on patients with unilateral facial nerve transections to acquire in vivo neural activity. We then identified the regions of interest corresponding to oral movement control using a smiling motor paradigm. Next, we established three local networks: the ipsilesional (left) intrahemispheric, contralesional (right) intrahemispheric, and interhemispheric networks. The functional connectivity of each pair of nodes within each network was then calculated. After thresholding for sparsity, we analyzed the mean intensity of each network connection between patients and controls by averaging the functional connectivity. For the objective assessment of facial deflection, oral asymmetry was calculated using FACEgram software. There was decreased connectivity in the contralesional network but increased connectivity in the ipsilesional and interhemispheric networks in patients with facial nerve lesions. In addition, connectivity in the ipsilesional network was significantly correlated with the extent of oral asymmetry. Our results suggest that motor deafferentation of unilateral facial nerve leads to the upregulated ipsilesional hemispheric connections, and results in positive interhemispheric inhibition effects to the contralesional hemisphere. Our findings provide preliminary information about the possible cortical etiology of facial asymmetry, and deliver valuable clues regarding spatial information, which will likely be useful for the development of therapeutic interventions.

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Tracking whole-brain connectivity dynamics in the resting-state fMRI with post-facial paralysis synkinesis

Cited by 7 publications

References 44 publications

A Triple-Network Dynamic Connection Study in Alzheimer's Disease

A Triple-Network Dynamic Connection Study in Alzheimer's Disease

Newly Prepared 129Xe Nanoprobe-Based Functional Magnetic Resonance Imaging to Evaluate the Efficacy of Acupuncture on Intractable Peripheral Facial Paralysis

Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry

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