“…1,2 Through software analysis, the trajectory and velocity of the virus in host cells can be accurately determined, and viral infection mechanisms, including entry pathways, transport dynamics, and virus−host interactions, can be directly observed, potentially offering opportunities for the development of new strategies to block viral infection. 3−7 Because of their wide range of colors and excellent photoluminescence and photostability, quantum dots (QDs) are ideal fluorescent probes for labeling viral envelopes, 8−11 capsids, 4,12 and nucleic acids 13−15 for long-term SVT. As many host cell receptor binding sites on the viral envelope are essential for viral uptake, packaging QDs into internal viral components is optimal to minimize impacts on viral entry and allows the monitoring of late infection events, enabling enhanced understanding of viral infection mechanisms.…”