Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs

Queiroz, Índia Olinta de Azevedo; Machado, Thiago; Alves, Camila Carneiro; Vasques, Ana Maria Veiga; Cury, Marina Tolomei Sandoval; Vasconcelos, Bruno Carvalho de; Gomes‐Filho, João Eduardo; Vivan, Rodrigo Ricci; Braga, Tiago Pinheiro; Love, Robert M.; Duarte, Marco Antônio Húngaro

doi:10.1016/j.jtemb.2021.126856

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…The included literature includes all types of sealers. The results of cell and animal experiments with some sealers are consistent with each other, such as BioRoot RCS [15,52], Total Fill BC [23,51], iRoot SP [28,63] and AH plus [31,51], et al…”

Section: Discussionsupporting

confidence: 70%

“…The observation indicators of in vivo implantation experiments were generally based on the ISO/TR7405‐199 standard to evaluate the inflammatory response and inflammatory cell infiltration in the tissues near the material [61]. There was also a research evaluated the biocompatibility of the sealers by tracking the toxic ions released by sealers into local and distant tissues [52]. Some scholars pointed out that in vitro cytocompatibility can only reflect the effect of materials on specific cells and could not fully reflect the complex host response [62].…”

Section: Resultsmentioning

confidence: 99%

“…The tissue implantation experiments of sealers were divided into two types: soft tissue implantation [20,[49][50][51][52][53][54][55][56] and bone tissue implantation [49,57]. Soft tissue implantation was to embed the fresh and sterile sealer in the subcutaneous connective tissue of animals and usually selected the tissue of the animal's back.…”

Section: Tissue Implantationmentioning

confidence: 99%

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A Review of the research methods and progress of biocompatibility evaluation of root canal sealers

et al. 2022

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The function of root canal sealer was to achieve an appropriate three‐dimensional filling effect by filling the root canal and some irregular lumen, thereby inhibiting the residual bacteria. There were many types of sealers, but research to find the most suitable ones was still ongoing. In recent years, researchers had continuously improved the performance of sealers by developing new sealers or adding active ingredients to the sealers. However, most sealers exhibit varying degrees of cytotoxicity and tissue responses, which affect clinical therapy efficacy. This review describes different technical approaches, and recent research progress in the biocompatibility evaluation of root canal sealers and provides brief insights into this field by summarising the performance studies of different root canal sealers.

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Section: Discussionsupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Section: Tissue Implantationmentioning

confidence: 99%

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A Review of the research methods and progress of biocompatibility evaluation of root canal sealers

et al. 2022

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“…Zirconium dioxide, Bismuth oxide or Tantalum pentoxide) and their release from periapical extrusion into the body fluids must be considered in future research. Recent ex vivo studies showed that, upon dissolution of CaSi sealers samples, the radiopacifiers could be spread in the surgical area, taken up by cells and transferred to other organs for their elimination by metabolic processes (de Azevedo Queiroz et al., 2021; Marciano et al., 2023).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis

Zamparini,

Lenzi,

Duncan

et al. 2024

Int Endodontic J

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BackgroundLimited evidence is available regarding the superior clinical properties of bioceramic sealers comparted with traditional standard sealers.ObjectivesThis review aimed to answer the following research questions: ‘In healthy patients requiring a root canal treatment (P), what is the efficacy of premixed bioceramic sealers (I) compared with traditional root canal epoxy resin‐based sealers (C) in terms of survival, success rates (PICO1) sealer extrusion and resorption (PICO2) post‐obturation pain (PICO3) (O)?’MethodsAuthors independently searched three electronic databases: PubMed (including MEDLINE), Web of Science, Embase and Scopus up to 31 October 2023. This was accompanied by both grey literature and manual search. Detailed selection criteria were applied, namely mature permanent teeth requiring root canal treatment, premixed bioceramic sealer with gutta‐percha as an intervention group, a standard filling technique as control group and full‐text available in English. A random‐effect meta‐analysis was used to synthesize the body of evidence regarding the use of bioceramic sealers in root canal treatment and their impact on post‐obturation pain. Effect sizes were represented as relative risks on a logarithmic scale for binary outcomes and as mean differences for continuous outcomes.ResultsA total of 941 articles were identified. Fifteen Comparative clinical studies were finally included. Eleven were randomized clinical trials, and four were prospective clinical trials with control group. The follow‐up of these studies was not greater than 2 years. No publication bias was observed in any study. No significant differences were observed between the two groups in terms of survival and success rates. A small non‐significant lower risk of extrusion was observed for bioceramics. A small, non‐significantly lower post‐operative‐pain within 24‐h was observed when bioceramics were used.DiscussionThe majority of current evidence shows inconsistencies in reporting and is of short‐term duration. Robust prospective long‐term trials are needed in this area to better support future recommendations.ConclusionThis systematic review is the first to analyse several clinical outcomes using premixed sealers. Included studies differed in terms of clinical protocol and operator expertise, but reported a similar outcome when comparing bioceramic versus standard sealers. Tooth survival, treatment outcome, post‐operative pain and periapical extrusion were similar and presented no significant differences between the two sealer types.RegistrationPROSPERO database (CRD42023449151).

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In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers

Malta,

Barcelos,

Fernandes

et al. 2024

Clin Oral Invest

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Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs

Cited by 4 publications

References 46 publications

A Review of the research methods and progress of biocompatibility evaluation of root canal sealers

A Review of the research methods and progress of biocompatibility evaluation of root canal sealers

The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis

In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers

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