Trachoma Control: A Glass Half Full?

Bilchut, Awraris Hailu; Burroughs, Hadley R; Oldenburg, Catherine E.; Lietman, Thomas M.

doi:10.4269/ajtmh.22-0760

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…This alliance supports implementing the SAFE (Surgery, Antibiotics, Facial Cleansing, and Environmental Improvement) intervention. In addition, the strengthening of national capacity regarding epidemiological studies, monitoring, surveillance, evaluation of projects, and the mobilization of resources (4) .…”

Section: Dear Editormentioning

confidence: 99%

Scientific production of trachoma worldwide: a bibliometric analysis during the period 1886 to 2022

Aquino-Canchari,

Chavez-Bustamante,

Zarate-Chavez

2023

An Fac med

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Estimado Editor, El tracoma es la principal causa infecciosa de ceguera evitable en todo el mundo (1). La bacteria Chla-mydia trachomatis lo causa y se caracteriza por cambios inflamatorios a nivel de la conjuntiva en niños con posterior cicatrización, opacidad de la córnea y ceguera en adultos. Se considera un problema de salud pública en 42 países (en junio de 2022). Es endémica en las zonas más pobres, desfavorecidas y rurales de África, América Central y del Sur, Asia, el Pacífico Occidental y Oriente Medio (2).

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Section: Dear Editormentioning

confidence: 99%

Scientific production of trachoma worldwide: a bibliometric analysis during the period 1886 to 2022

Aquino-Canchari,

Chavez-Bustamante,

Zarate-Chavez

2023

An Fac med

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“…It is estimated that an additional 6.2 million people are unilaterally blind. According to the WHO, 1.9 million instances of this opacification of the cornea are due to trachoma, an infection caused by the bacteria Chlamydia trachomatis [5,6]. The remaining cases of corneal opacification are due to a great number of other factors, such as onchocerciasis, vitamin A deficiency, tumors, and wounds [7,8].…”

Section: Introductionmentioning

confidence: 99%

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Volatier,

Cursiefen,

Notara

2024

Cells

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Corneal stromal stem cells (CSSCs) are of particular interest in regenerative ophthalmology, offering a new therapeutic target for corneal injuries and diseases. This review provides a comprehensive examination of CSSCs, exploring their anatomy, functions, and role in maintaining corneal integrity. Molecular markers, wound healing mechanisms, and potential therapeutic applications are discussed. Global corneal blindness, especially in more resource-limited regions, underscores the need for innovative solutions. Challenges posed by corneal defects, emphasizing the urgent need for advanced therapeutic interventions, are discussed. The review places a spotlight on exosome therapy as a potential therapy. CSSC-derived exosomes exhibit significant potential for modulating inflammation, promoting tissue repair, and addressing corneal transparency. Additionally, the rejuvenation potential of CSSCs through epigenetic reprogramming adds to the evolving regenerative landscape. The imperative for clinical trials and human studies to seamlessly integrate these strategies into practice is emphasized. This points towards a future where CSSC-based therapies, particularly leveraging exosomes, play a central role in diversifying ophthalmic regenerative medicine.

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Assessing Water, Sanitation and Hygiene Access and Use in Nabilatuk District, Uganda: A Cross-Sectional Study of Different Data Collection Methods

Colding-Jørgensen

Muheki

Baayenda

et al. 2023

Hygiene

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Good access and appropriate use of Water, Sanitation and Hygiene (WASH) is important in the control, elimination and eradication of a number of neglected tropical diseases (NTDs). Poor WASH access and use may explain continued high trachoma prevalence in Nabilatuk district, Uganda. This study aimed to investigate the level of WASH access and use through different WASH data collection methods and the triangulation of their results. A mixed-methods cross-sectional study was conducted in 30 households in Nabilatuk district, from 10 households in each of three nomadic villages. The data collection methods used were: (1) direct observations of routine WASH behaviours; (2) structured quantitative household questionnaires; (3) demonstrations of specific WASH behaviours. With regards to access, observations indicated less WASH access and use compared with questionnaire responses: the questionnaire indicated all households had access to an improved water source, but 70% had a >30-min round-trip, and no households had access to an improved latrine, whereas some observations indicated longer water collection times. In terms of behaviour, there were also differences between the data collection methods, with demonstrations revealing knowledge of good practice, such as thorough handwashing, but this was not routinely observed in the observations. Further systematic investigation of barriers to appropriate WASH access and use in the local context is needed, as is the development of feasible, valid and reliable WASH access and use assessment methods for use in national NTD programmes.

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Trachoma Control: A Glass Half Full?

Cited by 3 publications

References 7 publications

Scientific production of trachoma worldwide: a bibliometric analysis during the period 1886 to 2022

Scientific production of trachoma worldwide: a bibliometric analysis during the period 1886 to 2022

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Assessing Water, Sanitation and Hygiene Access and Use in Nabilatuk District, Uganda: A Cross-Sectional Study of Different Data Collection Methods

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