Tracheomalacia

McNamara, V.M; Crabbe, David

doi:10.1016/j.prrv.2004.01.010

Cited by 99 publications

(91 citation statements)

References 10 publications

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“…The overall impression of stanozolol administration to the owners, and subsequently to us, was enthusiastic. DISCUSSION TM is a rare disorder, although its true incidence is unknown, because it is generally considered underdiagnosed (4,(12)(13). Its severity varies and it is classified as congenital (primary) and acquired (secondary) (14).…”

Section: Personal Observation Andfollow-upmentioning

confidence: 99%

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Conservative Management of Canine Tracheal Collapse with Stanozolol: A Double Blinded, Placebo Control Clinical Trial

Adαmama-Moraitou

Pardali

Athanasiou

et al. 2011

Int J Immunopathol Pharmacol

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The objective of this study is to determine the efficacy of stanozolol in the treatment of tracheal collapse (TC) in dogs, which is the analogous disease to tracheomalacia (TM) in humans. Twenty-two dogs with endoscopically confirmed and graded TC were enrolled into five groups. Groups 81 (n=5), 82 (n=5) and 83 (n=4) with grade 1, 2 and 3 TC, respectively, received stanozolol orally for 75 days, while groups PI (n=4) and P2 (n=4) with grade 1 and 2 TC, respectively, received placebo. The clinical score was evaluated every 15 days, whereas TC grade was reassessed at the end of the experiment. Clinical improvement was detected from the 30 th day in 82 and 83 group dogs and from the 45 th day in 81 group dogs and continued until the end of the experiment. Also, statistically significant differences were seen between 82 and P2 dogs from the 30 th day, and between 81 and PI dogs from the 60 th day, and continued until the end of the study. Amelioration of the TC grade was seen in 13 of 14 (92.9%) dogs, which received stanozolol. Of the 14 dogs, 57.1% were cured and 35.8% demonstrated a less severe TC grade, while only one dog (7.1%) did not improve at all. Stanozolol seems to be an effective drug in the management of canine TC and it may have potential for use in humans with TM.

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Section: Personal Observation Andfollow-upmentioning

confidence: 99%

“…Excessive dynamic airway collapse (EDAC) is currently considered a distinct clinicopathologic entity and it may reflect the dynamic component ofTC (1). Apart from history and physical examination, a thorough diagnostic work-up should be performed in order to establish a definitive diagnosis, in both human and canine disease (4)(5).…”

mentioning

confidence: 99%

Conservative Management of Canine Tracheal Collapse with Stanozolol: A Double Blinded, Placebo Control Clinical Trial

Adαmama-Moraitou

Pardali

Athanasiou

et al. 2011

Int J Immunopathol Pharmacol

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“…Tracheobronchomalacia (TBM) is characterized by tracheobronchial collapse during the exhalatory phase of respiration due to weakness of the airway walls [1] . The primary form of TBM occurs due to congenital absence of tracheal cartilage, mostly in infants [1] .…”

Section: Introductionmentioning

confidence: 99%

“…The primary form of TBM occurs due to congenital absence of tracheal cartilage, mostly in infants [1] . In adults, a secondary form is seen most commonly in middle and older age groups.…”

Section: Introductionmentioning

confidence: 99%

Tracheobronchomalacia as a Rare Cause of Chronic Dyspnea in Adults

Uyar

Şanlı²,

Kervancıoğlu³

et al. 2017

Med Princ Pract

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Objective: To emphasize the importance of a careful clinical evaluation to prevent unnecessary interventions and treatments. Clinical Presentation and Intervention: A 76-year-old female patient had been diagnosed with asthma during previous admissions to different hospitals. She had also undergone fiberoptic bronchoscopy (FOB) on 2 occasions for evaluation of right middle lobe atelectasis observed on computed tomography. A repeated FOB revealed tracheobronchomalacia and nodular bronchial amyloidosis. A silicone Y stent was inserted, but the dyspnea increased. Excessive granulation tissue developed, and the patient died despite ventilatory support. Conclusion: The stenting technique used did not prevent the development of respiratory failure and death in this patient. Hence, a surgical procedure could be considered as an alternative to stenting in such cases.

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“…4 Upper airway obstruction is relatively common in young children. 6 Although tracheomalacia and bronchomalacia appear mainly during infancy, some cases do not cause problems until later in childhood, 7 various symptoms may suggest asthma, such as barking cough, respiratory distress and wheeze, and these may be misdiagnosed as asthma. [8][9][10][11] Upper airway obstruction may produce respiratory failure, and if recognized, many of the lesions producing upper airway obstruction are amenable to corrective surgery.…”

Section: Introductionmentioning

confidence: 99%

Forced inspiratory flow volume curve in healthy young children

Vilozni

Efrati

Barak

et al. 2009

Pediatric Pulmonology

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Summary. Introduction: Spirometry testing should include both expiratory and inspiratory measurements. Inspiratory forced maneuvers can demonstrate extrathoracic airway abnormalities, of which various symptoms may suggest asthma. However, the inspiratory portion of the forced flow/volume maneuver in young healthy children has not yet been described. Objectives: To document and analyze the forced inspiratory flow volume curve indices in healthy young children. Settings and Participants: Healthy preschool children (age 2.5-6.5 years) from community kindergartens around Israel. Methods: The teaching method included multi-target, interactive spirometry games and accessory games for inspiration (e.g., inspiratory whistle). Results: One hundred and fourteen out of a total of 157 children performed duplicate full adequate inspiratory maneuvers. Repeatability between two maneuvers was 5.6%, 4.0%, 5.1%, 7.3% for inspiratory capacity (IC), forced inspiratory vital capacity (FIVC), peak inspiratory flow (PIF), and mid inspiratory flow (FIF50). Inspiratory flow indices were significantly lower than the expiratory flow indices. The time to reach PIF was significantly longer (mean AE SD; 229 AE 21 msec) than the time to reach peak expiratory flow (92 AE 8 msec; P < 0.0001). The shape of the inspiratory curve was parabolic and did not vary with age. The formed predicted equations were in agreement with the extrapolated values for older healthy children. Conclusions: The majority of healthy young children can perform reliable maximum inspiratory flow volume curves. Our results provide a framework of reference equations for maximum inspiratory flow volume curve in the young children. The clinical applications of these equations have to be explored.

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Tracheomalacia

Cited by 99 publications

References 10 publications

Conservative Management of Canine Tracheal Collapse with Stanozolol: A Double Blinded, Placebo Control Clinical Trial

Conservative Management of Canine Tracheal Collapse with Stanozolol: A Double Blinded, Placebo Control Clinical Trial

Tracheobronchomalacia as a Rare Cause of Chronic Dyspnea in Adults

Forced inspiratory flow volume curve in healthy young children

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