Tracheal relaxation of five Ivorian anti-asthmatic plants: Role of epithelium and K+ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark

Irie-N’Guessan, Genéviève; Champy, Pierre; Kouakou-Siransy, Gisèle; Koffi, A. M.; Kablan, Brou Jérôme; Leblais, Véronique

doi:10.1016/j.jep.2011.09.016

Cited by 15 publications

(10 citation statements)

References 33 publications

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“…Salbutamol induced its spasmolytic effect in a different way [from the lowest concentrations its relaxant effect appeared and reached the maximal level at 9 × 10 −6 M, then decreased for the highest concentrations ( Figure 3)], due to a difference in the mechanisms of action. Indeed, the spasmolytic effect of the crude extract from which alkaloids were isolated was not inhibited by β 2 -blockers, but was sustained by hyperpolarization [5]; however salbutamol is known to have a β 2 -mimetic action [9]. Besides, the increase of salbutamol's spasmolytic effect, for its lowest concentrations, testimonies β 2 -receptors sensitation.…”

Section: Resultsmentioning

confidence: 99%

“…In Ivory Coast, whereas the root decoction is used as mouthwash in case of tooth decays by people of the North, people of the South use it to treat asthma [3]. As asthma is a respiratory disorder which is essentially characterized by the restriction of tracheal muscles obstructing the air circulation [4], the tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root bark was previously shown [5]. Besides, bisnordihydrotoxiferine, a tertiary indole alkaloid isolated from the root of Strychnos divaricans was shown to antagonize ace-tylcholine-induced contractions in rat uterus and in guineapig ileum [6]; other alkaloids were also shown to have spasmolytic effects on guinea-pig isolated trachea contracted by carbachol, histamine, or KCl [7].…”

Section: Introductionmentioning

confidence: 99%

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Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)

N’guessan-Irié¹,

Dade²,

Champy³

et al. 2013

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Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medicine to treat asthma, which is a respiratory disorder characterized by inflammation and the restriction of tracheal muscles obstructing the air circulation. The tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root bark was previously shown. For the present study, alkaloids were isolated from the same extract and investigated ex vivo in C57Bl/6j mice isolated trachea contracted with carbachol 1 µM, in comparison with a reference bronchodilatator, i.e. salbutamol. Two extraction procedures allowed isolating 2 Alkaloids that monodimensional and bi-dimensional nuclear magnetic resonance (NMR) and mass specters allowed identifying a pyrolidine structure type nucleus with a long bi-hydroxyled alkyl chain. Alkaloid 1, carrier of a sugar, is a glycoside of Alkaloid 2. Both alkaloids induced similar spasmolytic effects, but Alkaloid 1 was more effective than Alkaloid 2 at 9 × 10 −6 M (p ˂ 0.01), 3 × 10 −5 M, and 9 × 10 −5 M (p ˂ 0.001). Salbutamol induced its spasmolytic effect in a different way, and its maximal effect E max (less than 30%) was obtained at 9 × 10 −6 M, while E max of both alkaloids (100%) was obtained at 3 × 10 −4 M.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)

N’guessan-Irié¹,

Dade²,

Champy³

et al. 2013

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“…Ex vivo activity: Irié-N'Guessan et al documented tracheal relaxation effect against carbachol (1 μ M) induced trachea contraction [61]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb:Boerhavia diffusaLinn.

Mishra

Aeri

Gaur³

et al. 2014

BioMed Research International

134

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Boerhavia diffusa (BD) is a plant of rasayana category as per ayurvedic claims. It is reported to possess antiaging, disease prevention, and life strengthening activities which hold enormous influence in disease burden and affordability/availability of healthcare in the world. Objective. This paper has been compiled to comment on the studies reported for BD to highlight its chemical and therapeutic potential along with its ethnopharmacological considerations. Methods. In the present paper, a detailed account of chemical constituents and pharmacological activities has been presented. All the findings were correlated with modern pharmacological activities to appraise the value of BD. Results. Chemical analysis of BD gives a wide variety of chemical constituents, namely, rotenoids, flavonoids, xanthones, purine nucleoside, lignans, and steroids. Various ethnopharmacological reports emphasize its role in disorders of reproductive system, gastrointestinal system, respiratory system, urinary system, hepatic system/jaundice, cardiovascular system, and cancer. Conclusions. The studies on the therapeutic activities of BD range from studies on crude extracts to isolated compounds; however some of the studies require sophistication and validated results. BD is a plant of enormous importance in the purview of its chemical and therapeutic properties.

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“…[44].Ils démontrent que c'est l'extrait méthanolique de Da qui induit la relaxation la plus importante sur des morceaux de trachéedesouris préalablement traitésavecducarbachol (EC50 : 0,16 µg/ml). L'effet reste encore marqué en utilisant un extrait éthanol-eau réalisé avecc ette même plante, à la différence de l'extraitaqueux peu actif dans ce test.…”

Section: Activitésa Ntiallergique Antiasthmatique Antitussiveunclassified

Desmodium adscendens . De l’usage traditionnel camerounais contre les hépatites à l’accompagnement des chimiothérapies

Tubéry¹,

Ragot²,

Lagarde³

et al. 2015

Hegel

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RésuméDesmodium adscendens (Da) est une espèce pantropicale qui jouit d'une réputation de plante médicinale pratiquement dans tous les pays où elle croît. C'est en 1965 que le Dr P. Tubéry,a lors médecin coopérant au nord Cameroun recueillit de la bouche d'un tradipraticien des informations concernant son usage contre les hépatites et son mode de préparation. Convaincu de l'efficacité de cette espèce et de son intérêt en thérapeutique, le Dr P. Tubéry l'introduisit en France et, avec la collaboration de Mme J. Ragot, pharmacienne, mena des travaux afind emieuxc erner ses indications thérapeutiques, sa pharmacologie et sa composition chimique, ce qui conduisit à la production d'une formulation galénique reproduisant l'efficacité thérapeutique de la préparation traditionnelle. La réputation de Da s'étendit progressivement jusqu'à connaître un grand succès, et actuellement en Europe, cette espèce est devenue une référence incontournable à l'instar du Chardon Marie (Silybum marianum L. Gaertn.),e np articulier pour toutes ses applications dans les pathologies du foie (atteintes chroniques ou aiguës, en tant qu'agent curatif et/ou préventif), mais aussi pour d'autres indications. Le but cet article est de faire le point sur les travaux réaliséss ur cette espèce, dans un but de validation et de recommandations d'usage. Mots-clés

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Tracheal relaxation of five Ivorian anti-asthmatic plants: Role of epithelium and K+ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark

Cited by 15 publications

References 33 publications

Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)

Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)

Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb:Boerhavia diffusaLinn.

Desmodium adscendens . De l’usage traditionnel camerounais contre les hépatites à l’accompagnement des chimiothérapies

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Tracheal relaxation of five Ivorian anti-asthmatic plants: Role of epithelium and K+ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark

Cited by 15 publications

References 33 publications

Isolation and Spasmolytic Evaluation of New Alkaloids from &lt;i&gt;Dichrostachys cinerea&lt;/i&gt; (L.) Wight et Arn. (Fabaceae)

Isolation and Spasmolytic Evaluation of New Alkaloids from &lt;i&gt;Dichrostachys cinerea&lt;/i&gt; (L.) Wight et Arn. (Fabaceae)

Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb:Boerhavia diffusaLinn.

Desmodium adscendens . De l’usage traditionnel camerounais contre les hépatites à l’accompagnement des chimiothérapies

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Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)

Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)