Tracheal neurilemmoma: Case report and review of the literature

Stack, Peter S.; Steckler, Robert M.

doi:10.1002/hed.2880120512

Cited by 10 publications

(9 citation statements)

References 14 publications

(1 reference statement)

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“…Benign endobronchial tumors themselves are uncommon, and of these, endobronchial schwannoma is a rare entity, constituting approximately 2% of benign tracheobronchial tumors 9. Although rare, schwannomas can occur in any area of the tracheobronchial tree, with intraluminal or extraluminal extensions 7,10,11…”

Section: Discussionmentioning

confidence: 99%

Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases

et al. 2013

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BackgroundIt has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic.MethodsWe reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features.ResultsThe present study included five female and two male patients, with ages ranging from 16 to 81 years (mean age, 44.9 years). The clinical presentation varied according to tumor size and location. Patients with more centrally (trachea or main bronchus) located tumors experienced respiratory symptoms (80%) more often than patients with more peripherally (lobar or segmental bronchus) located tumors (0%). Histologically, the tumors were composed of spindle cells that stained with S100 protein. Some of the tumors showed typical Antoni A areas with Verocay body formation. Five of six patients (83.3%) underwent complete tumor removal by rigid bronchoscopy.ConclusionsPathologists should consider endobronchial schwannoma in the differential diagnosis of a spindle cell tumor involving the bronchus. Additionally, our results showed that rigid bronchoscopy is an effective tool for tumor removal in endobronchial schwannoma patients.

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Section: Discussionmentioning

confidence: 99%

Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases

et al. 2013

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“…The symptoms in patients with early stage subglottic tumor were not significant and characterized by dyspnea, cough, and stridor, which were often wrongly diagnosed as asthma. The disease is often diagnosed at a late stage, leading to delay in treatment (Stack and Steckler, 1990;Javadi et al, 2002;Horiuchi et al, 1987;Sur et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Subglottic adenoid cystic carcinoma mistaken for asthma

Wang

2009

J. Zhejiang Univ. Sci. B

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Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography (CT) revealed that her upper airway was obstructed by a laryngeal tumor. The patient was diagnosed with a subglottic adenoid cystic carcinoma and treated with complete surgical excision and adjuvant radiation therapy. Follow-up endoscopy and laryngeal magnetic resonance imaging (MRI) at six months showed no recurrence of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.

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“…The differential diagnosis of a tracheal mass includes malignant (squamous cell carcinoma, adenoid cystic carcinoma, and carcinoid) as well as benign tumors, such as papilloma, hemangioma, hamartoma, and neurilemmomas and neurofibromas. 7 Neurilemmomas (schwannomas) are usually single, encapsulated lesions composed of Schwann cells attached to a nerve but containing no neurons (in contrast to neurofibromas, which do contain neurons, and are usually multiple, unencapsulated lesions). Additionally, while neurofibromas are commonly associated with neurofibromatosis and occasionally undergo malignant degeneration, neurilemmomas do not.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors have been treated with endoscopic resection, 8,12,14 operative resection through a tracheal or laryngeal fissure, 7 as well as by tracheal resection. 8 There is one prior report of endoscopic NdYAG laser resection.…”

Section: Discussionmentioning

confidence: 99%