Tracheal inflammatory response to bacterial cellulose dressing after surgical scarification in rabbits

Panerari, Angelo D'urso; Costa, Henrique Olival; Souza, Flávia Coelho de; Castro, Marí­lia Germanos de; Silva, Leonardo da; Neto, Osmar Mesquita de Sousa

doi:10.1016/s1808-8694(15)30597-8

Cited by 5 publications

(3 citation statements)

References 25 publications

(45 reference statements)

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“…It has also been used as a substitute for meninges, dorsum of the nose, tympanic membrane, as a lining for intravascular prostheses, and in the trachea to avoid circumferential stenosis. [25][26][27][28] Although the material has been tested in other animal models, the evaluation did not included the larynx; hence, situations, such as tissue reaction, material absorption, and extrusion, need to be addressed to evaluate its usefulness as a material for laryngeal reconstruction. The aim of this study was to evaluate the medialization, inflammatory response, and healing of rabbit vocal folds after implantation of a membrane of bacterial cellulose.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose as Laryngeal Medialization Material: An Experimental Study

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose as Laryngeal Medialization Material: An Experimental Study

et al. 2011

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“…BC was observed to allow the repairing of dural defects in rabbit and had a decreased inflammatory response compared to traditional materials. Panerari et al [72] studied in vivo , using rabbits as animal models, the use of a commercial product from BC (Bionext ® ) as a dressing to prevent scarring tissue formation, following tracheal stenosis surgery. Bionext dressings were observed not to induce acute inflammatory response, up to 180 days following scarification.…”

Section: Inflammatory Responsementioning

confidence: 99%

A Review on the toxicology and dietetic role of bacterial cellulose

2017

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Bacterial cellulose (BC) is a biopolymer synthesized by certain acetic acid bacteria strains. The safety of BC regarding its potential use in food applications is here reviewed. The acute, sub-acute and subchronic oral toxicity assays showed that consumption of BC had no adverse effects in rats. Several studies demonstrated that BC is not genotoxic, did not induce chromosomal aberrations in CHO cells under both non-activating and metabolic activating conditions, is inactive in the in vitro Rat Primary Hepatocyte Unscheduled DNA Synthesis Assay, had no reproductive toxicity in mice and exerted no embryotoxicity and teratogenicity effects in rats.Several studies on the BC in biomedical applications further reinforces its safety: a primary eye and dermal irritation studies in the rabbit showed that BC was non-irritating. The inflammatory reaction to subcutaneously implanted BC has been evaluated in animal models and for different periods of time, demonstrating that BC is biocompatible and does not trigger a harsh inflammatory reaction.Altogether, and considering its longstanding history of human consumption in Asian countries, as well as its utilization in biomedical devices, it may be concluded that BC is safe for applications in food technology.

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“…Panerari et al [117] used BC dressings for treatment of laryngotracheal scarification in rabbit with absence of chronic inflammatory reaction and effective healing. Additionally, BC also has been used as graft for laryngeal medicalization in the rabbit, not promoting a significant foreign-body reaction in comparison to the control group, thyroid cartilage [118].…”

Section: Scaffoldmentioning

confidence: 99%