Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

Zhang, Ran; Li, Yán; Hu, Bingbing; Lü, Zhiguo; Zhang, Jinchao; Zhang, Xin

doi:10.1002/adma.201600554

Cited by 88 publications

(62 citation statements)

References 39 publications

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“…Zhang et al synthesized a traceable SPOINS system by using a poly(carboxybetaine) polymer‐based NP and conjugated cell‐penetrating peptide (CPP) as the targeting ligand. Due to enhanced proton relaxation in the brain tissue, enhanced MRI contrast was observed . Another study demonstrated that the application of an external magnetic field mediated the ability of magnetic NPs (MNP) to permeate the BBB and accumulate in the brain, with no observable toxicity.…”

Section: Nanocarriers As Drug Delivery Systemsmentioning

confidence: 99%

Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials

Tsou

Zhang²,

Zhu

et al. 2017

Small

169

120

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A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood-brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer-based, lipid-based, and inorganic-based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases.

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Section: Nanocarriers As Drug Delivery Systemsmentioning

confidence: 99%

Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials

Tsou

Zhang²,

Zhu

et al. 2017

Small

169

120

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“…Real‐time monitoring of the in vivo tissue regeneration process is vital for successful treatment. For example, as an important part of regenerative medicine, stem cell therapy offers the promise of rebuilding the injured heart from its component parts, structural repair of the brain and the spinal cord, as well as Alzheimer's disease therapy . Several stem cell therapies have been applied to clinical trials .…”

Section: Mions In Regenerative Medicine Applicationsmentioning

confidence: 99%

Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges

et al. 2018

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The recent emergence of numerous nanotechnologies is expected to facilitate the development of regenerative medicine, which is a tissue regeneration technique based on the replacement/repair of diseased tissue or organs to restore the function of lost, damaged, and aging cells in the human body. In particular, the unique magnetic properties and specific dimensions of magnetic nanomaterials make them promising innovative components capable of significantly advancing the field of tissue regeneration. Their potential applications in tissue regeneration are the focus here, beginning with the fundamentals of magnetic nanomaterials. How nanomaterials—both those that are intrinsically magnetic and those that respond to an externally applied magnetic field—can enhance the efficiency of tissue regeneration is also described. Applications including magnetically controlled cargo delivery and release, real‐time visualization and tracking of transplanted cells, magnetic regulation of cell proliferation/differentiation, and magnetic activation of targeted ion channels and signal pathways involved in regeneration are highlighted, and comments on the perspectives and challenges in magnetic nanomaterial‐based tissue regeneration are given.

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“…Recently, traceable PHEMA-RA-PCB-CPP/SPIONs/siSOX9 nanoparticles (ABC/SPIONs/siSOX9 NPs) have been developed for treatment of AD. The complex NPs control siSOX9 delivery, which is faster than RA, leading to downregulation SOX9 protein expression [77]. Therefore, ABC/SPIONs/siSOX9 NPs can efficiently control the differentiation of NSCs into neurons.…”

Section: Combination Of Rnai and Stem Cells For Treatment Of Cns Dmentioning

confidence: 99%

“…Therefore, ABC/SPIONs/siSOX9 NPs can efficiently control the differentiation of NSCs into neurons. Moreover, after transplantation of NSCs treated with ABC/SPIONs/siSOX9 NPs, APPswe/PS1dE9 transgenic AD mice display enhanced spatial learning and memory in the Morris water-maze test and increased neurons in the hippocampus as indicated by Nissl staining analysis [77]. The results from these studies suggest that SOX9 RNAi, together with RA, may enhance the neuronal differentiation of stem cells and replace degenerated neurons.…”

Section: Combination Of Rnai and Stem Cells For Treatment Of Cns Dmentioning

confidence: 99%

Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

Hou

Wang

et al. 2017

Genes

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RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.

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Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

Cited by 88 publications

References 39 publications

Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials

Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials

Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges

Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

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