The outbreak of the novel coronavirus disease quickly spread all over China and to more than 20 other countries. Although the virus (SARS-Cov-2) nucleic acid RT-PCR test has become the standard method for diagnosis of SARS-CoV-2 infection, these real-time PCR test kits have many limitations. In addition, high false negative rates were reported. There is an urgent need for an accurate and rapid test method to quickly identify large number of infected patients and asymptomatic carriers to prevent virus transmission and assure timely treatment of patients.We have developed a rapid and simple point-of-care lateral flow immunoassay which can detect IgM and IgG antibodies simultaneously against SARS-CoV-2 virus in human blood within 15 minutes which can detect patients at different infection stages. With this test kit, we carried out clinical studies to validate its clinical efficacy uses. The clinical detection sensitivity and specificity of this test were measured using blood samples collected from 397 PCR confirmed COVID-19 patients and 128 negative patients at 8 different clinical sites. The overall testing sensitivity was 88.66% and specificity was 90.63%. In addition, we evaluated clinical diagnosis results obtained from different types of venous and fingerstick blood samples. The results indicated great detection consistency among samples from fingerstick blood, serum and plasma of venous blood. The IgM-IgG combined assay has better utility and sensitivity compared with a single IgM or IgG test. It can be used for the rapid screening of SARS-CoV-2 carriers, symptomatic or asymptomatic, in hospitals, clinics, and test laboratories.

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The anode oxygen evolution reaction (OER) is knownt ol argely limit the efficiency of electrolyzerso wing to its sluggish kinetics.W hile crystalline metal oxides are promising as OER catalysts,t heir amorphous phases also show high activities.E fforts to produce amorphous metal oxides have progressed slowly, and how an amorphous structure benefits the catalytic performances remains elusive. Now the first scalable synthesis of amorphous NiFeMo oxide (up to 515 gi no ne batch) is presented with homogeneous elemental distribution via afacile supersaturated co-precipitation method. In contrast to its crystalline counterpart, amorphous NiFeMo oxide undergoes af aster surface self-reconstruction process during OER, forming am etal oxy(hydroxide) active layer with rich oxygen vacancies,leading to superior OER activity (280 mV overpotential at 10 mA cm À2 in 0.1m KOH). This opens up the potential of fast, facile,a nd scaleup production of amorphous metal oxides for high-performance OER catalysts.

Exploring low-cost and high-performance nonprecious metal catalysts (NPMCs) for oxygen reduction reaction (ORR) in fuel cells and metal-air batteries is crucial for the commercialization of these energy conversion and storage devices. Here we report a novel NPMC consisting of Fe3 C nanoparticles encapsulated in mesoporous Fe-N-doped carbon nanofibers, which is synthesized by a cost-effective method using carbonaceous nanofibers, pyrrole, and FeCl3 as precursors. The electrocatalyst exhibits outstanding ORR activity (onset potential of -0.02 V and half-wave potential of -0.140 V) closely comparable to the state-of-the-art Pt/C catalyst in alkaline media, and good ORR activity in acidic media, which is among the highest reported activities of NPMCs.

Exploring low‐cost and high‐performance nonprecious metal catalysts (NPMCs) for oxygen reduction reaction (ORR) in fuel cells and metal–air batteries is crucial for the commercialization of these energy conversion and storage devices. Here we report a novel NPMC consisting of Fe3C nanoparticles encapsulated in mesoporous Fe‐N‐doped carbon nanofibers, which is synthesized by a cost‐effective method using carbonaceous nanofibers, pyrrole, and FeCl3 as precursors. The electrocatalyst exhibits outstanding ORR activity (onset potential of −0.02 V and half‐wave potential of −0.140 V) closely comparable to the state‐of‐the‐art Pt/C catalyst in alkaline media, and good ORR activity in acidic media, which is among the highest reported activities of NPMCs.