Trace voltammetric measurements of cancerostatic actinomycin-C1

Abstract

Abstract. This article describes how Analysis of Variance may be used to select those regions of the curves generated by a gas sensor ar ray which contain the most discriminant information for a particular application. The Analysis of Variance is performed on each point of the signals generated by the sensor array for a particular set of samples. The Group Variances and the Residual Variances are plotted as functions of their position in the signal. Regions of the signals that vary systematically from one group of samples to another will have high Group Variance values and low and randomly distributed Residual Variance values. This method has shown for a particular set of products for cats analysed with a thirty two polymer sensor array, that the most discriminant information is located at the end of the curves. It has also shown an absence of discrimination between standard and tainted pig fat samples with this sensor array. The ad vantage of this method is that it can be used on almost any sort of raw signal as a pre-analysis step in order to know whether it is worthwhile going on to more fastidious and time consuming signal analysis procedures.

The Experimental Design Approach in Square‐Wave Voltammetric Determination of Tamoxifen by NiO‐CPE**

“…Among the chemical compounds, anticancer drugs are highly electroactive due to their structural OH and NH2 functional groups. Thus, they appear to have a high electrochemical signal due to the electro‐oxidation of such functional groups or oxidative cyclization reactions [48–54] …”

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

“…The application of electrochemical techniques in the analysis of drugs and pharmaceutical products either in biological medium has increased considerably in recent years (Table 1). [33–68] The renewed interest in electrochemical techniques can be attributed in part to more sophisticated instrumentation and increased understanding of the technique themselves. The application of different electrochemical modes in the analysis of drugs and pharmaceuticals are available for the quantification of drugs.…”