Trace Mineral Status Related to Levels of Glycated Hemoglobin of Type 2 Diabetic Subjects in Jeddah , Saudi Arabia

The Relationship between Hypomagnesaemia and Glycemic Control in Children with Type 1 Diabetes Mellitus

“…who made a Comparative study on magnesium in diabetic and non-diabetic patients and found a significant fall of serum magnesium in patients with diabetes [6] and Pham et al [7] who studied lower serum magnesium levels association with more rapid decline of renal function in patients with diabetes mellitus and also reported hypomagnesaemia in 47.7% of non-hospitalized patients with diabetes mellitus [7,8] studied the trace mineral status related to levels of glycated hemoglobin of diabetic subjects, and explained the hypomagnesaemia that associated with diabetes mellitus by osmotic diuresis which is the cause for magnesium loss. It is believed that glycosuria that accompanies the diabetic state impairs renal tubular reabsorption of magnesium from glomerular filtrate.…”

“…It is believed that glycosuria that accompanies the diabetic state impairs renal tubular reabsorption of magnesium from glomerular filtrate. Conversely, insulin deficiency may explain the increased urinary magnesium excretion, because insulin has been recognized to stimulate magnesium conservation in the loop of Henle and distal tubule [8]. Moreover, uncontrolled hyperglycemia and hyperglycuria may increase magnesium excretion through osmotic diuresis, leading to a vicious circle [9].…”

Association of Serum Selenium, Zinc and Magnesium Levels with Glycaemic Indices and Insulin Resistance in Pre-diabetes: a Cross-Sectional Study from South India

“…It also has a role in the stabilisation of insulin hexamers and its storage in the pancreas [11,12]. Apart from being a cofactor in the glucose transport system of hepatocyte plasma membranes and catalysing the key enzymes in the phosphorylation of glucose; Mg is also known to increase the affinity and number of insulin receptors [2,13]. Hruby et al [10] observed a 6 % lower HOMA-IR in subjects with higher Mg intake after 7 years than those with lower Mg intake, thus indicating the importance of Mg for maintenance of long-term healthy insulin metabolism.…”

Effects of Antioxidant Micronutrients against CVD Risk in Type 2 Diabetes Mellitus: A Systematic Review

“…However, in the study by Olaniyan et al [13], there was no correlation between serum zinc levels and fasting blood glucose in type 2 diabetic patients. Also, it was observed that type 2 diabetic patients with HbA1c greater than 8% had strong correlation with regard to altered serum zinc compared to those with HbA1c less than 8% [11]. This means that altered zinc levels can enhance increase in blood glucose.…”

“…Hyperglycemia increases risk of oxidative damage on endothelial cells, leading to atherosclerosis in type 2 diabetes [10]. It was noted that serum zinc level had inverse correlation with glycated hemoglobin levels of type 2 diabetic patients [11][12]. This implies that an increase in zinc concentration in blood will cause decrease in glycated hemoglobin in type 2 diabetics.…”