Trace lithium is inversely associated with male suicide after adjustment of climatic factors

Shiotsuki, Ippei; Terao, Takeshi; Ishii, Nobuyoshi; Takeuchi, Shigeru; Kuroda, Yoshiki; Kohno, Kentaro; Mizokami, Yoshinori; Hatano, Koji; Tanabe, Sanshi; Kanehisa, Masayuki; Iwata, Noboru; Matusda, Shinya

doi:10.1016/j.jad.2015.09.070

Cited by 37 publications

(55 citation statements)

References 28 publications

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“…The lithium levels of water were measured by using mass spectroscopy analyzed by a third party [2,4,5]. This method can measure very small amounts of lithium; the limit of quantification of lithium is 0.1 ppb (0.1 μg/L).…”

Section: Methodsmentioning

confidence: 99%

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Comparison of lithium levels between Japanese and foreign mineral waters

Ishii¹,

Terao²,

Shiotsuki³

et al. 2017

CNPT

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Purpose: To measure the lithium levels of mineral waters and compare those of Japanese mineral waters to foreign ones. Methods: The lithium levels of Japanese mineral waters, foreign mineral waters, and Japanese tap waters were compared using the Kruskal-Wallis test due to a skewed distribution. Results: As a whole, there was a significant difference between the 3 groups. Post hoc comparison by Bonferroni correction revealed that the lithium levels of foreign mineral waters were significantly higher than Japanese mineral waters and tap waters, though there was no significant difference between Japanese mineral waters and tap waters. Discussion: The present findings indicate that foreign mineral waters may have higher lithium levels than Japanese mineral waters and tap waters. In future studies, it is desirable to consider which type of mineral waters (Japanese or foreign) the residents drink, for adjustment of the analytic data of any potential lithium effect on suicide rates and other mental states.

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Section: Methodsmentioning

confidence: 99%

“…Several epidemiological studies have shown the inverse association of lithium levels in tap water and suicide rates [1][2][3][4][5][6], although a few studies failed to find such association [7] or have reported an ambiguous association [8]. However, many people drink both mineral water and tap water.…”

Section: Introductionmentioning

confidence: 99%

Comparison of lithium levels between Japanese and foreign mineral waters

Ishii¹,

Terao²,

Shiotsuki³

et al. 2017

CNPT

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“…La cantidad de zinc en el cuerpo está alrededor de 40 mg por kilogramo y el funcionamiento de muchas enzimas requieren su participación (alrededor de 100): metabolismo de proteínas y ácidos nucleicos, funcionamiento adecuado del sistema inmune, procesos de cicatrización de las heridas, procesos de percepciones del gusto y el olfato y en la síntesis del ADN [7,22,23].…”

Section: Zincunclassified

“…El déficit de zinc puede dar lugar a alteraciones inmunitarias, facilita procesos infecciosos, condiciona enfermedad diarreica, lesiones cutáneas como erupciones dérmicas, además de problemas neuropsiquiátricos [22]. Cambios en la homeostasis de zinc en el cerebro se han asociado con alteraciones comportamentales, problemas de aprendizaje, alteraciones de la función cognitiva y ciertos trastornos neurológicos.…”

Section: Zincunclassified

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Elementos traza y trastorno afectivo bipolar

Ramírez¹,

Solarte²,

Restrepo

2017

UNIV.MED.

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Introducción: Los elementos traza u oligoelementos son micronutrientes disponibles en mínima cantidad en el cuerpo humano y constituyen funciones vitales, lo que les confiere su importancia. El exceso o déficit en las concentraciones de oligoelementos como zinc, litio, cobre y plomo podrían estar involucrados en las diferentes fases del trastorno afectivo bipolar. Objetivo: Analizar la información actual disponible en la literatura sobre la relación entre elementos traza y el trastorno afectivo bipolar. Métodos: Búsqueda en paralelo por dos revisores en las bases de datos Ovid, Pubmed, SciELO y Cochrane. Resultados: Se encontraron un total de 47 artículos publicados entre 1988 y 2015, aunque al final se evaluaron 12 artículos en texto completo. Conclusiones: La literatura disponible sugiere asociación entre altas cantidades de zinc en fase maniaca y escasa presencia en la fase depresiva de pacientes con trastorno afectivo bipolar. No se encontró asociación significativa con los otros oligoelementos.

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Could Lithium in Drinking Water Reduce the Incidence of Dementia?

McGrath

Berk

2017

JAMA Psychiatry

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Now more than ever, the research community should be concentrating on finding ways to reduce the incidence of dementia. The population is aging, and the number of individuals affected by dementia remains a major public health challenge. The reality is that we have no effective treatments for dementia. In the absence of treatments to cure the disorder (or even reduce the associated burden by delaying onset or reducing disability), the prevention of dementia must be a priority research topic. Modifiable risk factors are associated with dementia 1 (eg, diabetes and attendant behavioral risks, such as diet and physical activity); these risk factors are important but complex targets for intervention. However, as with many neurologic and psychiatric disorders, we have a scant appreciation of the environmental risk factors that contribute to dementia risk. There is an urgent need to generate new candidate risk factors for dementia. In contrast to genetics, for which there are now cost-efficient, high-throughput screening methods that can generate genetic candidates, epidemiology relies on a mix of creative researchers and access to suitable databases that contain the variables of interest. Epidemiologists are envious of our colleagues in genetics, in which the search space for risk variants is more tractable and bounded. The study by Kessing and colleagues 2 presents evidence that low lithium concentration in the drinking water may be associated with an increased risk of dementia. The hypothesis is surprising but is mechanistically plausible. The hypothesis builds on preliminary evidence from clinical trials that suggest that lithium supplementation may improve cognitive outcomes in groups with mild cognitive impairment 3 and Alzheimer disease. 4 The new study links Danish health registers with area-level studies that map observed and imputed lithium concentrations in drinking water supplies. The link between lithium and neuropsychiatry has a venerable history. More than 50 years ago, Australian 5 and Danish psychiatrists 6 pioneered the use of lithium as a treatment for mania. Attempts have been made to reverse engineer the neurobiology of bipolar disorder from the known biological properties of lithium. However, lithium affects many biological pathways linked to neuroprogressive and neurodegenerative disorders. 7 For example, lithium affects diverse homeostatic mechanisms that include intracellular calcium, microglial activation, glutamate excitotoxicity, apoptosis and autophagy, inflammation, oxidative stress, and mitochondrial dysfunction. Lithium increases synaptic

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Trace lithium is inversely associated with male suicide after adjustment of climatic factors

Cited by 37 publications

References 28 publications

Comparison of lithium levels between Japanese and foreign mineral waters

Comparison of lithium levels between Japanese and foreign mineral waters

Elementos traza y trastorno afectivo bipolar

Could Lithium in Drinking Water Reduce the Incidence of Dementia?

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