Trace elements in milk

Murthy, G.K.; Thomas, J. W.

doi:10.1080/10643387409381609

Cited by 33 publications

(6 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean concentration of chromium in mature human milk is 0.27 J..Lg/1 (Casey et a/., 1985), much lower than earlier reported values, e.g. 29 J..Lg/1 (Murthy, 1974). The more recent values for the concentration of chromium in milks are more reliable due to improved analytical methodology.…”

Section: Chromiummentioning

confidence: 61%

“…Dietary zinc supplementation increases the zinc concentration in cow's milk only slightly (Murthy, 1974).…”

Section: Zincmentioning

confidence: 96%

“…The iron content of cow's milk is resistant to changes in dietary iron intake (Murthy et al, 1972;Murthy, 1974). Contact with metal containers can increase the concentration of iron in cow's milk (Jarrett, 1979) In cow's milk, 14% of the iron occurs in milk fat (Fransson and Lonnerdal, 1983) where it is associated with the fat globule membrane.…”

Section: Nutritional Aspects Of Minerals In Milksmentioning

confidence: 99%

“…The concentration of copper in cow's milk decreases by up to 50% during the first 3 days of lactation (de Maria, 1978); it can be increased by dietary copper supplementation (Murthy, 1974) or by contact with metal containers and processing equipment (Roh et a/., 1976). Contamination of cow's milk with copper from brass containers has been cited as the major environmental factor in the aetiology of Indian childhood cirrhosis (Tanner et a/., 1983; Bhave et a/., 1987).…”

Section: Coppermentioning

confidence: 99%

See 3 more Smart Citations

Advanced Dairy Chemistry Volume 3

Fox¹

1997

View full text Add to dashboard Cite

Section: Chromiummentioning

confidence: 61%

“…Dietary zinc supplementation increases the zinc concentration in cow's milk only slightly (Murthy, 1974).…”

Section: Zincmentioning

confidence: 96%

Section: Nutritional Aspects Of Minerals In Milksmentioning

confidence: 99%

Section: Coppermentioning

confidence: 99%

See 2 more Smart Citations

Advanced Dairy Chemistry Volume 3

Fox¹

1997

View full text Add to dashboard Cite

“…The data for zinc levels in milk report values around 50 M; however, these were most likely total, not free Zn(II) concentrations. 23 The only carefully measured value for unliganded zinc was reported in horse serum at levels around 10 Ϫ10 M, which would certainly rule out the significance of most or all of the function extrapolated to breast fluid or milk. 24 Although lactose biosynthesis and secretion occur in the Golgi lumen of the lactating mammary gland cell, detailed metal ion measurements in this organelle have yet to be reported.…”

Section: Physiological Significance Of Zinc Binding To ␣-Lactalbuminmentioning

confidence: 98%

Zinc binding in bovine ?-lactalbumin: Sequence homology may not be a predictor of subtle functional features

et al. 2000

View full text Add to dashboard Cite

alpha-Lactalbumin (alpha-LA), a calcium-binding protein, also possesses zinc-binding sites comprising a single strong site and several weaker secondary sites. The only site found by X-ray crystallography (Ren et. al., J. Biol. Chem. 1993;268:19292) was Glu 49 of human alpha-LA, but zinc binding had never been measured in solution for human alpha-LA. This residue was genetically substituted by Ala in bovine alpha-LA and the metal-binding properties of the resulting desMetE49A protein were compared with those for native alpha-LA by fluorescence methods. Surprisingly, desMetE49A alpha-LA and the native bovine protein had similar affinities for both Zn(2+) and Ca(2+). Genetic substitution of other possible candidates for Zn(2+) chelating residues, which included Glu 25, did not alter the affinity of bovine alpha-LA to Zn2+; however, substitution of Glu 1 by Met resulted in the disappearance of strong Zn(2+) binding. A proposed site involves Glu 1, Glu 7, Asp 11, and Asp 37, which would participate in strong Zn(2+) binding based on their propinquity to Glu 1. Human alpha-LA, which has a Lys at position 1 rather than Glu, binds zinc with a reduced affinity compared with native bovine alpha-LA, suggesting that the site identified from the X-ray structure did not correspond to strong zinc binding in solution.

show abstract