Trace elemental correlation study in malignant and normal breast tissue by PIXE technique

Raju, G. J. Naga; Sarita, P.; Kumar, M. Ravi; Murty, G. A. V. Ramana; Reddy, B. Seetharami; Lakshminarayana, S.; Vijayan, V.; Lakshmi, P. Vinotha Boorana; Gavarasana, Satyanarayana; Reddy, S. Bhuloka

doi:10.1016/j.nimb.2006.02.007

Cited by 73 publications

(52 citation statements)

References 79 publications

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“…In earlier studies, mean concentrations of Cr, Ca, Fe, Cu, and Zn were reported to be significantly higher in malignant and benign breast tissues compared with the controls [19,22,32]. In another study [33], it was suggested that reactive chromium intermediates such as Cr(V) and Cr(IV) generate hydroxyl radicals, which cause deoxyribonucleic acid (DNA) strand breaks, base modification, and lipid peroxidation and also inactivate p53.…”

Section: Resultsmentioning

confidence: 99%

“…Epidemiological studies showed that the majority of the factors leading to the development of malignant tumor in humans have arisen from environmental factors including the work environment, followed by nutritional habits as well as viral attacks and only meagerly as consequences of genetic predispositions [14,15]. Several studies have focused on the relationship between trace metal and breast cancer in humans, which indicated that the trace metals may influence the carcinogenic process [16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha

Malik

Iqbal³

et al. 2008

Biol Trace Elem Res

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Selected trace metals were analyzed in human malignant and nonmalignant (benign) breast tissue samples by the flame atomic absorption spectrophotometric method. In malignant tissues, dominant mean concentrations were revealed by Na, K, Ca, Mg, Fe, Zn, and Al at 927, 552, 231, 61.7, 36.5, 18.3, and 8.94 microg/g, respectively, while the mean metal levels in benign tissues were 903, 435, 183, 63.3, 24.7, 14.5, and 10.1 microg/g, respectively. Average concentrations of Cd, Co, Cr, Cu, Fe, Mn, K, Ca, and Zn were noted to be significantly higher in the malignant tissues compared with the benign tissues. Significantly strong correlations (r > 0.50) in malignant tissues were observed between Mn and Co, Mn and Cd, Cd and Cr, Fe and Mn, Cd and Co, Fe and Co, Mg and Pb, Cd and Fe, Mg and Ni, Pb and Ni, Ni and Sr, and Fe and Pb, whereas, Cd and Co, Cd and Mn, Co and Mg, Co and Mn, Cu and Mn, Co and Ni, Mg and Ni, Cd and Cu, Cd and Ni, Ca and Mg, Mn and Pb, Cu and Ni, Fe and Ni, Cd and Mg, Co and Cu, Cr and Na, and Cd and Cr revealed strong and significant relationships in benign tissues at p < 0.001. Principal component analysis of the metals data yielded six principal components for malignant tissues and five principal components for benign tissues, with considerably different loadings, duly supported by cluster analysis. The study revealed a considerably different pattern of distribution and mutual correlations of trace metals in the breast tissues of benign and cancerous patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha

Malik

Iqbal³

et al. 2008

Biol Trace Elem Res

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“…Comparative studies carried out recently on normal and cancerous human tissues report controversial results, especially for some elements such as Cu, Fe, Ni, Se and Zn. In general, most of authors found significantly elevated concentrations or non-differences for several elements in malignant tissues (Raju et al 2006;Ionescu et al 2006;Ebrahim et al 2007), however, decreases in concentration have also been reported (Zoriy et al 2006).…”

Section: Introductionmentioning

confidence: 94%

“…In recent years, the interest for understanding the role of alterations in element homeostasis and in the etiology of cancer has dramatically increased (Raju et al 2006). Comparative studies carried out recently on normal and cancerous human tissues report controversial results, especially for some elements such as Cu, Fe, Ni, Se and Zn.…”

Section: Introductionmentioning

confidence: 99%

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

et al. 2009

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Tumorous and adjacent non-tumorous paired biopsies from 38 patients with colorectal cancer were analyzed by inductively coupled plasma mass spectrometry and inductively coupled plasma optical emission spectrometry after low-volume microwave digestion. 18 elements were investigated: Ag, Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Ni, P, Pb, S, Se and Zn. Different chemometric tools were used for data evaluation: Wilcoxon signed rank test, Hieratical clustering analysis, principal component analysis (PCA) and linear discriminant analysis (LDA). With the exception of Al, tumours were observed to have significantly more elevated concentrations of essential elements as compared to non-tumours. On the contrary, elements considered potentially carcinogenic such as Cr, Ni, Mo or Co do not display significant differences. When PCA was applied, different components were obtained for tumorous and non-tumorous tissues. When LDA was applied for the elements studied (including essential and non-essential elements) about 90% of cases were correctly classified.

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“…In recent years, there has been growing interest in understanding the exact role played by trace elements in several diseases. The biological function of some metal ions in combination with an investigation of element distribution patterns in malignant and in normal human tissues of cancer patients can give some indication of the effect of metal ions on carcinogenesis (Raju et al, 2006). Both excess and deficiency of trace elements have been associated with many diseases including cancer.…”

Section: Introductionmentioning

confidence: 99%

X-Ray Fluorescence Microtomography in Biological Applications

Pereira¹,

Lopes²

2011

Computed Tomography - Special Applications

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Trace elemental correlation study in malignant and normal breast tissue by PIXE technique

Cited by 73 publications

References 79 publications

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

X-Ray Fluorescence Microtomography in Biological Applications

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