Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha, Qaisara; Malik, Salman Akbar; Iqbal, Javed; Shaheen, N.; Shah, Munir H.

doi:10.1007/s12011-008-8158-z

Cited by 49 publications

(31 citation statements)

References 36 publications

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“…There were 13 studies including 978 exposed cases and 1279 controls ( Figure 1) (Antila et al, 1996;Ionescu et al, 2006;McElroy et al, 2006;Wu et al, 2006;Pasha et al, 2008;Strumylaite et al, 2008;Gallagher et al, 2010;Benderli Cihan et al, 2011;Saleh et al, 2011;Strumylaite et al, 2011;Kotsopoulos et al, 2012;Nagata et al, 2013). The characterization of all selected studies was summarized in Table 1.…”

Section: Meta-analysismentioning

confidence: 99%

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Rahim

Jalali²,

Tangestani³

2013

Asian Pacific Journal of Cancer Prevention

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Background: In this meta-analysis we review evidence suggesting that exposure to cadmium is a cause of breast cancer. Materials and Methods: We conducted Medline/PubMed and Scopus searches using selected MeSH keywords to identify papers published from January 1, 1980 through January 1, 2013. Data were merged and summary mean differences were estimated using either a random-effects model or a fixed-effects model. Results: There were 13 studies including 978 exposed cases and 1,279 controls. There was no statistically significant difference in the frequencies of breast cancer between cadmium-exposed and control groups, and the summary estimate of mean difference was 0.71 (95%CI: 0.33-1.08). However, stratification showed that there were statistically significant differences in the frequencies of breast cancer between cadmium-exposed and control groups among Asian compared with Caucasian population, and the summary estimates of mean difference were 1.45 (95%CI: 0.62-2.28) vs. 0.25 (95%CI: -0.09-0.6), respectively. There was a difference in the frequencies of breast cancer between cadmium-exposed and control groups in peripheral venous blood sampling methods, and the summary estimate of mean difference was 1.41 (95%CI: 0.46-2.37). Conclusions: Data indicate that the frequencies of breast cancer might be an indicator of early genetic effects for cadmium-exposed populations. However, our meta-analysis was performed on population-based studies; meta-analysis based on individual data might provide more precise and reliable results. Therefore, it is necessary to construct an international database on genetic damage among populations exposed to cadmium that may contain all raw data of studies examining genetic toxicity.

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Section: Meta-analysismentioning

confidence: 99%

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Rahim

Jalali²,

Tangestani³

2013

Asian Pacific Journal of Cancer Prevention

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“…Exposure to reactive oxygen species (ROS) can lead to direct DNA damage, mutation, and carcinogenesis [6,7]. Previous studies have reported alterations in the concentrations of serum or neoplastic tissue trace elements in various carcinomas including breast, bladder, gastric, gallbladder, and lung cancers [1,[8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Khoshdel

Naghibalhossaini

Abdollahi

et al. 2015

Biol Trace Elem Res

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Alterations of trace element concentrations adversely affect biological processes and could promote carcinogenesis. Only a few studies have investigated the degree of changes in copper and zinc levels in colorectal cancer (CRC). The aim of the present study was to compare the serum copper (Cu) and zinc (Zn) concentrations in patients with CRC from Iran with those of healthy subjects. Cu and Zn concentrations in the serum of 119 cancer patients and 128 healthy individuals were measured by atomic absorption spectrometry. We found a significant decrease in the total mean serum Cu and Zn concentrations in CRC patients as compared with the control group (137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05 vs. 141.64 ± 51.75, respectively). However, the serum Cu/Zn ratio in the patient group was significantly higher than that measured in the control group (p = 0.00). There was no significant difference in the mean values of serum Cu and Zn concentrations between young (<60 years) and elderly (≥60 years) patients. However, the Cu/Zn ratio in <60-year cases was significantly higher than that in ≥60-year age group (p < 0.05). In addition, mean serum Cu level in normal weight patients was significantly higher than that in overweight/obese cases (132.31 ± 87.43 vs. 103.81 ± 53.72 μg/dl, respectively) (p < 0.05). There was no difference in mean serum Cu and Zn concentrations in patients stratified by the site, stage, or differentiation grade of tumors. Our findings suggest that imbalance in Cu and Zn trace element level is associated with CRC and might play an important role in cancer development among Iranian patients.

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“…Most breast cancers initially develop as hormone-dependent cancer, which can later develop into a more hostile, hormone-independent tumor. A number of epidemiological studies have been carried out to understand the hormone-refractory breast cancer development, which evidenced the involvement of endocrine disruptors including trace elements [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Trace Elements in the Scalp Hair of Malignant and Benign Breast Lesions Versus Healthy Women

Pasha

Malik

Shaheen

et al. 2009

Biol Trace Elem Res

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Trace elements including Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Sb, Sr, and Zn were analyzed in the scalp hair samples of women with malignant breast lesions, women with benign breast lesions, and healthy donors using atomic absorption spectrophotometric method. In the scalp hair of malignant-tumor patients, the highest average concentration was shown by Ca (1,187 microg/g), followed by Na (655 microg/g), Mg (478 microg/g), Zn (391 microg/g), Sr (152 microg/g), Fe (114 microg/g), and K (89.8), while in the case of benign-tumor patients, the average estimated element levels were 1,522, 1,093, 572, 457, 217, 80.4, and 74.7 microg/g, respectively. Most of the elements exhibited non-normal distribution evidenced by large spread, standard error, and skewness values. Mean concentrations of Ca (634 microg/g), Zn (206 microg/g), Mg (162 microg/g), Fe (129 microg/g), and Na (82.1 microg/g) were noteworthy in the scalp hair of healthy women. Average levels of Na, Sr, K, Cd, Co, Pb, Mg, Ca, Zn, Ni, Sb, and Mn were revealed to be significantly higher in the hair of malignant and benign patients compared to the healthy women; however, Fe, Cu, Al, and Cr were not significantly different in the scalp hair of the three groups. The quartile distributions of Ca, Cd, Co, Cr, K, Mg, Mn, Na, Ni, Pb, Sb, and Sr revealed maximum spread in the scalp hair of malignant and benign groups; nevertheless, Al, Cu, Fe, and Zn exhibited almost comparable quartile levels in the three groups. Strong correlation coefficients were found between Fe and Cd, Al and Na, Mn and Sr, Co and Cr, Cd and Cr, Pb and K, Pb and Mn, Cu and Na, and Al and Fe in the scalp hair of malignant-tumor patients, while Fe and K, Cd and Co, Na and Co, and Cr and Pb showed strong correlations in the scalp hair of benign-tumor patients, both of which were significantly different compared with the healthy subjects. Multivariate cluster analysis also revealed divergent clustering of the elements in the scalp hair of malignant and benign patients in comparison with the healthy women.

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Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Cited by 49 publications

References 36 publications

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Comparison of Trace Elements in the Scalp Hair of Malignant and Benign Breast Lesions Versus Healthy Women

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