Trace elemental analysis of carcinoma kidney and stomach by PIXE method

Reddy, S. Bhuloka; Charles, M.; Raju, G. J. Naga; Vijayan, V.; Reddy, B. Seetharami; Kumar, M. Ravi; Sundareswar, B.

doi:10.1016/s0168-583x(03)00463-4

Cited by 52 publications

(29 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…K is required by glycolytic enzymes, this has much higher activity in carcinoma of rectum and colon than in adjacent non tumour tissues. High activity of pyruvate kinase in colon and rectum tumorous cells has been observed, what would explain the accumulation of this element in tumorous tissues (Reddy et al 2003).…”

Section: Statistical Comparison Of Datamentioning

confidence: 93%

“…In adenomatous polyps, associated with a greater risk of cancer, significantly lower levels have been found (Alimonti et al 2008). Metallothioneins take part of Cd detoxication and they also protect the tissues from the effects of free radicals; these processes can be related to a decrease in cadmium levels in tumorous tissues (Reddy et al 2003).…”

Section: Statistical Comparison Of Datamentioning

confidence: 99%

See 1 more Smart Citation

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

et al. 2009

View full text Add to dashboard Cite

Tumorous and adjacent non-tumorous paired biopsies from 38 patients with colorectal cancer were analyzed by inductively coupled plasma mass spectrometry and inductively coupled plasma optical emission spectrometry after low-volume microwave digestion. 18 elements were investigated: Ag, Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Ni, P, Pb, S, Se and Zn. Different chemometric tools were used for data evaluation: Wilcoxon signed rank test, Hieratical clustering analysis, principal component analysis (PCA) and linear discriminant analysis (LDA). With the exception of Al, tumours were observed to have significantly more elevated concentrations of essential elements as compared to non-tumours. On the contrary, elements considered potentially carcinogenic such as Cr, Ni, Mo or Co do not display significant differences. When PCA was applied, different components were obtained for tumorous and non-tumorous tissues. When LDA was applied for the elements studied (including essential and non-essential elements) about 90% of cases were correctly classified.

show abstract

Section: Statistical Comparison Of Datamentioning

confidence: 93%

Section: Statistical Comparison Of Datamentioning

confidence: 99%

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Reddy et al observed that zinc concentration in kidney cancer tissue was higher than control group. Hence, it was concluded that zinc is involved in the tumor growth and development of neoplastic transformation in kidney [29]. Zoriy et al has tried to develop an analytical technique to figure out the elemental distribution (Cu, Zn, Pb, and U) in histological sections of glioblastoma multiforme which is known to be the most common primary human brain tumor [30].…”

Section: Zincmentioning

confidence: 99%

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Bakırdere

Kizilkan

Yaman

2010

Biol Trace Elem Res

View full text Add to dashboard Cite

The levels of zinc, copper, iron, and manganese were measured in the hippocampus, thalamus, gyrus cinguli, hypothalamus, and in the prefrontal, parietal, temporal, and occipital cortexes of lamb brain by flame atomic absorption spectrometry. Standard addition method was also applied to samples and it was observed that there was no matrix interference affecting the determination of elements interested. In the determination of Cu, a slotted tube atom trap was used to improve sensitivity. One-way analysis of variance was used for the statistical evaluation of the results for each element. Limit of detection results for Zn, Cu, Fe, and Mn were found to be 24, 4.5, 60, and 25 ng/mL, respectively. Region-specific differences were found for all elements interested. Mn concentration ranging from 0.29 ± 0.04 to 0.61 ± 0.04 mg/kg was found to be the lowest in all brain regions among the all elements interested.

show abstract

“…In addition, differences in zinc concentration in different disease have been observed. The values are in mean ± SD Reddy et al [31] showed that concentration of zinc in cancer tissue of kidney was observed to be higher then control group. This observation suggests that zinc is involved in the tumor growth and development of neoplastic transformation in kidney.…”

Section: Kidneymentioning

confidence: 99%

Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats

Özen

Kuş

Bakırdere

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation. After inhalation procedure, concentration of copper, zinc and iron were determined in liver and kidney tissues of rats using atomic absorption spectrophotometer. In addition, concentrations of Cu, Zn and Fe changed by the effect of formaldehyde in subacute and subchronic groups.

show abstract

Trace elemental analysis of carcinoma kidney and stomach by PIXE method

Cited by 52 publications

References 34 publications

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

Elemental fingerprinting of tumorous and adjacent non-tumorous tissues from patients with colorectal cancer using ICP-MS, ICP-OES and chemometric analysis

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats

Contact Info

Product

Resources

About