Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats

Abstract

In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation. After inhalation procedure, concentration of copper, zinc and iron were determined in liver and kidney tissues of rats using atomic absorption spectrophotometer. In addition, concentrations of Cu, Zn and Fe changed by the effect of formaldehyde in subacute and subchronic groups.

Inhibition of ferroptosis‐like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats

“…To obtain a dry mass, spinal samples (0.1 to 0.2 g) were dried at 60°C for 12 hr. Samples were first digested with 1 ml nitric acid (60%) at 100°C in a water bath for 2 hr, carrying on the digestion after the addition of hydrogen peroxide (0.5 ml) for 30 min upon boiling (Ozen et al., 2011). The totally dissolved residues were diluted to 10 ml with double distilled water prior to calculations.…”

Serum Amiloid-A'nın Sıçanlarda Formaldehit Kaynaklı Kupffer Hücre Apoptozundaki Rolü ve Astaksantin'in Bu Süreçteki Olası Koruyucu Etkileri

“…CH 2 O is metabolized in the liver after ingestion(6,21). The detoxifying process of CH 2 O in the liver may indirectly cause oxidative stress(21,22).Researchers have found that a marked formation of ROS when rat hepatocytes were incubated with CH 2 O (5). Due to oxidative stress(6,17), there may be an interaction between pathological changes in KCs and SAA level and an increase in the apoptosis index.…”