Trace element study of kidney stones from subjects belonging to stone belt region of India

Srivastava, Alok Kumar; Swain, K. K.; Ajith, Nicy; Wagh, D. N.; Acharya, R.; Reddy, Α. V. R.; Mete, Uttam

doi:10.1007/s10967-011-1553-5

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…Very few results are available in literature which reports the analysis of urinary stones particularly using XRF techniques . Sometimes, the literature often refers to an entire group of urinary stones without any classification or simply divides them into a few groups.…”

Section: Resultsmentioning

confidence: 99%

“…Bazin et al and Blaschko et al have used XRF technique to detect the heavy elements Cu, Fe, Pb, Rb, Se, Sr, Zn and Ca, Fe, Pb, Sr, Zn, respectively. Srivastava et al utilized INAA and EDXRF techniques to quantify elements Ca, Na, K, Mn, Co, Cr, Zn, Br, and Sm in kidney stones obtained from six patients belonging to the stone belt region of India (Punjab). Gurol et al used EDXRF to quantify some elements such as Ca, K, Cl, P, and S in some human urinary stones using calibration standard method.…”

Section: Resultsmentioning

confidence: 99%

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Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

et al. 2017

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Kidney stone is the most painful and prevalent urological disorder of the urinary system throughout the world. Thus, analysis of kidney stones is an integral part in the evaluation of patents having stone disease. Spectroscopic investigations of stones provide an idea about the pathogenesis of stones for its better cure and treatment. Hence, the present work targets multispectroscopic investigations on kidney stones using Fourier transform infrared (FTIR) and wave dispersive X-ray fluorescence (WD-XRF) spectroscopy which are the most useful analytical methods for the purpose of bio-medical diagnostics. In the present study, FTIR spectral method is used to investigate the chemical composition and classification of kidney stones. The multicomponents of kidney stones such as calcium oxalate, hydroxyl apatite, phosphates, carbonates, and struvite were investigated and studied. Qualitative and quantitative determination of major and trace elements present in the kidney stones was performed employing WD-XRF spectroscopy. The wide range of elements determined in the kidney stones were calcium (Ca), magnesium (Mg), phosphorous (P), sodium (Na), potassium (K), chlorine (Cl), sulfur (S), silicon (Si), iodine (I), titanium (Ti), iron (Fe), ruthenium (Ru), zinc (Zn), aluminum (Al), strontium (Sr), nickel (Ni), copper (Cu), and bromine (Br). For the first time, ruthenium was detected in kidney stone samples employing WD-XRF in very low concentration. Our results revealed that the presence and relative concentrations of trace elements in different kinds of stones are different and depend on the stone types. From the experiments carried out on kidney stones for trace elemental detection, it was found that WD-XRF is a robust analytical tool that can be useful for the diagnosis of urological disorders. We have also compared our findings with the results reported using XRF technique. The results obtained in the present paper show interesting prospects for FTIR and WD-XRF spectrometry in nephrolithiasis. Copyright

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

et al. 2017

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“…Bazin et al (2007) employed the XRF technique to quantify Cu, Fe, Pb, Rb, Se, Sr, and Zn in calcium oxalate, calcium phosphate, struvite, uric acid, cystine, and mixed type urinary stones. Srivastava et al (2012) employed INAA and EDXRF techniques to quantify Ca, Na, K, Mn, Co, Cr, Zn, Br, and Sm in kidney stones taken from Indian patients. The same group (Srivastava et al 2014) also applied instrumental neutron activation analysis (INAA), EDXRF and XRD techniques to analyze kidney stones extracted from Indian patients.…”

Section: Studies On Stones Using Ftir Spectroscopymentioning

confidence: 99%

Analysis of stones formed in the human gall bladder and kidney using advanced spectroscopic techniques

Singh¹,

Jaswal²,

Sharma³

et al. 2020

Biophys Rev

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Stone diseases (gallstones and kidney stones) are extremely painful and often cause death. The prime aim of biomedical research in this area has been determination of factors resulting in stone formation inside the gallbladder and urinary tract. Many theories have been put forward to explain the mechanism of stone formation and their growth; however, their complete cycle of pathogenesis is still under debate. Several factors are responsible for stone formation; however, much emphasis is placed on the determination of elemental and molecular composition of the stones. In the present review article, we describe different kinds of spectroscopic techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence (XRF) spectroscopy, time-of-flight secondary ion mass spectrometry (TOF-SIMS), and laser-induced breakdown spectroscopy (LIBS) and highlight their use in the analysis of stone diseases. We have summarized work done on gallstones and kidney stones using these advanced techniques particularly over the last 10 years. We have also briefly elaborated the basics of stone formations inside the human body and their complications for a better understanding of the subject.

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“…The solutes in this supersaturated urine gradually crystallize, forming minute particles that progressively grow into solid cores. These cores aggregate over time, culminating in the development of complete urinary stones, which may accumulate within the urinary stones and eventually be expelled through the urethra, causing symptoms of urinary tract stones [33]. Despite an incomplete understanding of the stone precipitation process, urinary stone analysis plays a crucial role in identifying the potential etiology and pathophysiology of stone formation.…”

Section: Introductionmentioning

confidence: 99%

The key role of major and trace elements in the formation of five common urinary stones

Tian,

Han,

Zhang

et al. 2024

BMC Urol

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Background Urolithiasis has emerged as a global affliction, recognized as one of the most excruciating medical issues. The elemental composition of stones provides crucial information, aiding in understanding the causes, mechanisms, and individual variations in stone formation. By understanding the interactions between elements in various types of stones and exploring the key role of elements in stone formation, insights are provided for the prevention and treatment of urinary stone disease. Methods This study collected urinary stone samples from 80 patients in Beijing. The chemical compositions of urinary stones were identified using an infrared spectrometer. The concentrations of major and trace elements in the urinary stones were determined using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS), respectively. The data were processed using correlation analysis and Principal Component Analysis (PCA) methods. Results Urinary stones are categorized into five types: the calcium oxalate (CO) stone, carbonate apatite (CA) stone, uric acid (UA) stone, mixed CO and CA stone, and mixed CO and UA stone. Ca is the predominant element, with an average content ranging from 2.64 to 27.68% across the five stone groups. Based on geochemical analysis, the high-content elements follow this order: Ca > Mg > Na > K > Zn > Sr. Correlation analysis and PCA suggested significant variations in the interactions between elements for different types of urinary stones. Trace elements with charges and ionic structures similar to Ca may substitute for Ca during the process of stone formation, such as Sr and Pb affecting the Ca in most stone types except mixed stone types. Moreover, the Mg, Zn and Ba can substitute for Ca in the mixed stone types, showing element behavior dependents on the stone types. Conclusion This study primarily reveals distinct elemental features associated with five types of urinary stones. Additionally, the analysis of these elements indicates that substitutions of trace elements with charges and ion structures similar to Ca (such as Sr and Pb) impact most stone types. This suggests a dependence of stone composition on elemental behavior. The findings of this study will enhance our ability to address the challenges posed by urinary stones to global health and improve the precision of interventions for individuals with different stone compositions.

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Trace element study of kidney stones from subjects belonging to stone belt region of India

Cited by 11 publications

References 13 publications

Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

Analysis of stones formed in the human gall bladder and kidney using advanced spectroscopic techniques

The key role of major and trace elements in the formation of five common urinary stones

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