Trace Element’s Role in Male Infertility; Review Article Mohamed Sobhy Abd Elhady*, Abdalla Hasan Kandil, Waleed Mohamed Albalat

Elhady, Mohamed Sobhy Abd; Kandil, Abdalla Hasan; Albalat, Waleed Mohamed

doi:10.21608/ejhm.2021.203735

Cited by 3 publications

(1 citation statement)

References 25 publications

(24 reference statements)

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“…Nutritional interventions may be essential to maintain male fertility and testosterone levels, which are directly related to sperm mitochondrial activity, a significant determinant of sperm quality. In addition, this effect depends on dietary factors that are both quantitative and qualitative, such as the number of calories in each macronutrient (carbohydrates, proteins, and fats), as well as in micronutrients, such as zinc, selenium, iron, and phosphorus [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence

Sheir

Serrapica

Ahmed

2023

Foods

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Propolis is a common natural ingredient used in food production, food packaging, and pharmaceutical products. Therefore, the aim of our study was to prepare dipping sauce powders as an innovative functional product with a regular and spicy taste from economical raw materials with high nutritional value. The developed products were fortified with propolis powder at 250, 500, and 750 mg/kg. All studied dipping sauces were subjected to a palatability test, a nutritional evaluation, and a microbiological assay performed during 6 months of storage. In addition, an in vivo study was designed to evaluate the efficacy of these products in preventing the testicular toxicity disorders induced by cadmium chloride (CdCl2) in albino rats. Based on the palatability test, the dipping sauces supplemented with propolis at 250 mg/kg and 500 mg/kg were preferred. Moreover, all samples were safe to consume within 6 months. Biological results showed that all investigated propolis-enriched dipping sauce samples caused an improvement in all CdCl2-induced testicular histopathological and biochemical changes, especially the spicy dipping sauce powder fortified with 500 mg/kg of propolis.

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Section: Resultsmentioning

confidence: 99%

An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence

Sheir

Serrapica

Ahmed

2023

Foods

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Assessment of serum essential/non-essential elements, biochemical variables and its association with semen parameters and the risk of male infertility

Kaur,

Kapoor

et al. 2024

Preprint

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Essential metals are involved in various cellular processes of the body and non-essential metals are toxic even in small amounts and have no biological role. The deficiency or over-exposure of these elements perturbs the reproductive health of males. A cross-sectional study has been conducted to investigate the association of a) essential (Cr, Co, Ni, Fe, Mn, Cu, Zn, Se) and non-essential elements (Pb, Cd, As, Ba, Bi, U, V); b) biochemical variables (glucose, triglycerides, cholesterol, HDL, LDL, albumin, and total protein) with risk of male infertility. A total of 46 males from infertile couples have been selected for the study. Serum element concentrations were estimated using ICP-MS and biochemical parameters were estimated by colorimetric methods. Statistical analysis was performed with IBM SPSS and R package. A significant difference was observed for Cr and LDL at p < 0.10 among study groups. Significant difference was found for spermatozoa volume, count and motility between study groups. Serum albumin levels are positively associated with sperm motility. Cr is negatively correlated with triglyceride levels (p = 0.03). Fe and Co are also significantly but negatively correlated with cholesterol levels (p = 0.05). Mn, Cu, Pd, Cd, and Ba are significantly positively correlated with semen volume. Cr, Co, Ni, Mn, Cu, Zn, Pd, Cd, As, Ba, U, and V are significantly positively correlated with liquefaction time (p < 0.05). The investigation of metals may help in the screening of male infertility as some metals may have therapeutic potential or toxic nature that can be used in the management of condition.

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An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

Maciejewski

Radzikowska-Büchner²,

Flieger

et al. 2022

IJERPH

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Numerous factors affect reproduction, including stress, diet, obesity, the use of stimulants, or exposure to toxins, along with heavy elements (lead, silver, cadmium, uranium, vanadium, mercury, arsenic). Metals, like other xenotoxins, can cause infertility through, e.g., impairment of endocrine function and gametogenesis or excess production of reactive oxygen species (ROS). The advancement of nanotechnology has created another hazard to human safety through exposure to metals in the form of nanomaterials (NMs). Nanoparticles (NPs) exhibit a specific ability to penetrate cell membranes and biological barriers in the human body. These ultra-fine particles (<100 nm) can enter the human body through the respiratory tract, food, skin, injection, or implantation. Once absorbed, NPs are transported to various organs through the blood or lymph. Absorbed NPs, thanks to ultrahigh reactivity compared to bulk materials in microscale size, disrupt the homeostasis of the body as a result of interaction with biological molecules such as DNA, lipids, and proteins; interfering with the functioning of cells, organs, and physiological systems; and leading to severe pathological dysfunctions. Over the past decades, much research has been performed on the reproductive effects of essential trace elements. The research hypothesis that disturbances in the metabolism of trace elements are one of the many causes of infertility has been unquestionably confirmed. This review examines the complex reproductive risks for men regarding the exposure to potentially harmless xenobiotics based on a series of 298 articles over the past 30 years. The research was conducted using PubMed, Web of Science, and Scopus databases searching for papers devoted to in vivo and in vitro studies related to the influence of essential elements (iron, selenium, manganese, cobalt, zinc, copper, and molybdenum) and widely used metallic NPs on male reproduction potential.

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Trace Element’s Role in Male Infertility; Review Article Mohamed Sobhy Abd Elhady*, Abdalla Hasan Kandil, Waleed Mohamed Albalat

Cited by 3 publications

References 25 publications

An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence

An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence

Assessment of serum essential/non-essential elements, biochemical variables and its association with semen parameters and the risk of male infertility

An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

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