Trace Element Concentration in Human Brain

Hock, Alfred Louis; Demmel, U.; Schicha, H.; Kasperek, K.; Feinendegen, L. E.

doi:10.1093/brain/98.1.49

Cited by 150 publications

(28 citation statements)

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“…From our data (Table 3) it can be seen that corresponding regions from the two hemispheres of three human brains revealed similar concentrations in general, which is in accordance with other essential element studies [26,27]. Interestingly, in certain cases (e.g.…”

Section: Resultssupporting

confidence: 90%

Iodine concentration in different human brain parts

Andrási¹,

Bélavári²,

Stibilj³

et al. 2004

Analytical and Bioanalytical Chemistry

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Iodine is one of the most important essential elements as demonstrated by the fact that its deficiency can cause goitre. Nevertheless, quantitative data on its concentration in biological materials, especially in the human brain, are scarce. There is therefore a demand for accurate and reliable information on iodine in these types of samples. The purpose of the present work was to determine the concentration of total iodine in some control human brain parts by rapid radiochemical neutron activation analysis. Our second goal was to determine I distribution between lipid fraction and in brain tissue without lipid by applying two types of solvent extraction methods. The results were checked by the analysis of biological standard reference materials with certified or literature values for iodine and good agreement was found.

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Section: Resultssupporting

confidence: 90%

Iodine concentration in different human brain parts

Andrási¹,

Bélavári²,

Stibilj³

et al. 2004

Analytical and Bioanalytical Chemistry

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“…However, during Se deficiency, the brain shows an ability to preserve this trace element, whereas other organs readily lose Se (13,15,46). In addition, several studies revealed that the regions of human brain enriched for gray matter tend to have higher Se levels, whereas white matter was found to have reduced Se, and Se appeared to concentrate in glandular parts of the brain (41,44,47). Similar patterns were observed for animals (48,49).…”

Section: Discussionmentioning

confidence: 62%

“…Numerous studies have examined the levels of Se in human and animal tissues and found an uneven distribution of this trace element (41)(42)(43)(44)(45). Se content of human brain (ϳ88 ng/mg wet weight) is much lower than that of kidney and liver (ϳ469 and ϳ221 ng/mg wet weight, respectively (45).…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Selenocysteine Machinery and Selenoproteome Gene Expression in Mouse Brain Identifies Neurons as Key Functional Sites of Selenium in Mammals

Zhang

Zhou

Schweizer

et al. 2008

Journal of Biological Chemistry

161

123

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Although dietary selenium (Se) deficiency results in phenotypes associated with selenoprotein depletion in various organs, the brain is protected from Se loss. To address the basis for the critical role of Se in brain function, we carried out comparative gene expression analyses for the complete selenoproteome and associated biosynthetic factors. Using the Allen Brain Atlas, we evaluated 159 regions of adult mouse brain and provided experimental analyses of selected selenoproteins. All 24 selenoprotein mRNAs were expressed in the mouse brain. Most strikingly, neurons in olfactory bulb, hippocampus, cerebral cortex, and cerebellar cortex were exceptionally rich in selenoprotein gene expression, in particular in GPx4, SelK, SelM, SelW, and Sep15. Over half of the selenoprotein genes were also expressed in the choroid plexus. A unique expression pattern was observed for one of the highly expressed selenoprotein genes, SelP, which we suggest to provide neurons with Se. Cluster analysis of the expression data linked certain selenoproteins and selenocysteine machinery genes and suggested functional linkages among selenoproteins, such as that between SelM and Sep15. Overall, this study suggests that the main functions of selenium in mammals are confined to certain neurons in the brain.

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“…After this, a gradual accumulation occurs with prominence seen in the globus pallidus, putamen, and substantia nigra in old age [3][4][5].…”

Section: Ironmentioning

confidence: 99%

“…Other trace metals found in the brain in significant amounts include copper, magnesium, and zinc [3,4]. In the normal state they appear to contribute little to MR imaging.…”

Section: Ironmentioning

confidence: 99%